Calmare Therapeutics Inc (fka CTTC)

[andy55q]

Support Care Cancer. 2016 Jun;24(6):2807-14. doi: 10.1007/s00520-016-3177-3. Epub 2016 Apr 4.
Scrambler Therapy for the management of chronic pain.
Majithia N1, Smith TJ2, Coyne PJ3, Abdi S4, Pachman DR5, Lachance D6, Shelerud R7, Cheville A7, Basford JR7, Farley D8, O'Neill C5, Ruddy KJ5, Sparadeo F9, Beutler A5, Loprinzi CL10.
Author information
1Internal Medicine, Mayo Clinic, Rochester, MN, USA.
2Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD, USA.
3Medical University of South Carolina, Charleston, SC, USA.
4Pain Medicine, MD Anderson Cancer Center, Houston, TX, USA.
5Medical Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
6Neurology, Mayo Clinic, Rochester, MN, USA.
7Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
8West Lynn Family Health Center, West Lynn, OR, USA.
9Salve Regina University, Newport, RI, USA.
10Medical Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. [e-mail].
Abstract
PURPOSE:
Chronic pain is a widespread and debilitating condition, encountered by physicians in a variety of practice settings. Although many pharmacologic and behavioral strategies exist for the management of this condition, treatment is often unsatisfactory. Scrambler Therapy is a novel, non-invasive pain modifying technique that utilizes trans-cutaneous electrical stimulation of pain fibers with the intent of re-organizing maladaptive signaling pathways. This review was conducted to further evaluate what is known regarding the mechanisms and mechanics of Scrambler Therapy and to investigate the preliminary data pertaining to the efficacy of this treatment modality.
METHODS:
The PubMed/Medline, SCOPUS, EMBASE, and Google Scholar databases were searched for all articles published on Scrambler Therapy prior to November 2015. All case studies and clinical trials were evaluated and reported in a descriptive manner.
RESULTS:
To date, 20 reports, of varying scientific quality, have been published regarding this device; all but one small study, published only as an abstract, provided results that appear positive.
CONCLUSION:
The positive findings from preliminary studies with Scrambler Therapy support that this device provides benefit for patients with refractory pain syndromes. Larger, randomized studies are required to further evaluate the efficacy of this approach.
KEYWORDS:
Chemotherapy-induced peripheral neuropathy; Chronic pain; Pain; Scrambler Therapy

http://www.ncbi.nlm.nih.gov/pubmed/?term=scrambler