Momenta Pharmaceuticals, Inc. (MNTA)

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Pre grant patent applications filed.

PHARMACEUTICAL COMPOSITIONS

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This disclosure relates to therapeutic and/or diagnostic formulations with altered, optimized, and/or improved characteristics.

061] In certain embodiments, the glycol split LMWH preparation is an M402 preparation. In one embodiment, the M402 preparation has a molecular weight distribution such that 10-40% of the oligosaccharides of the preparation have a molecular weight <3000 Da; 45-65% of the oligosaccharides have a molecular weight between 3000-8000 Da, and 15-30% of the oligosaccharides have a molecular weight >8000 Da.

Another filing,

Pharmaceutical Compositions Comprising Pyrophosphate

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1. An aqueous pharmaceutical composition, the composition comprising a. a therapeutic agent, e.g., a therapeutic polypeptide or a therapeutic polysaccharide; and b. pyrophosphate, e.g., 5 mM-250 mM pyrophosphate.

0009] In some embodiments, the therapeutic agent is a therapeutic antibody preparation (e.g., abciximab, adalimumab, alemtuzumab, basiliximab, bevacizumab, certolizumab, cetuximab, daclizumab, eculizumab, efalizumab, gemtuzumab, ibritumomab, infliximab, muromonab-CD3, natalizumab, omalizumab, palivizumab, panitumumab, ranibizumab, rituximab, tositumomab, or trastuzumab).


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