Revance Therapeutics Inc (RVNC)

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[Open Access] Guidelines Updated on Botulinum Toxin for Brain Disorders
http://www.neurology.org/content/early/2016/04/15/WNL.0000000000002560.abstract

The American Academy of Neurology has updated its 2008 guidelines on using botulinum toxin for brain disorders.

One of the main changes: Botulinum toxin A is now recommended for the management of chronic migraine, defined as attacks lasting 4 or more hours on at least 15 days each month for 3 months. Previously, there wasn't enough evidence for this recommendation, but new placebo-controlled studies show a small, 15% reduction in the number of headache days with treatment. Botulinum toxin A is not recommended for less frequent, "episodic" migraine.

In addition, the guidance states that botulinum toxin is generally safe and effective for treating spasticity in adults, cervical dystonia, and blepharospasm.