Trillium Therapeutics Inc (TRIL)

[NY1972]

MCSF-polarized M2 macrophages as well as CSC-conditioned
M2-like macrophages were able to phagocytose PDAC
cells treated with anti-CD47 mAbs highlights the potential of M2
macrophages, the predominant macrophage subtype present with
the PDAC tumor microenvironment, as biologic tools to target
CSCs and their more differentiated non-CSCs progenies.

.. tumors with their dense stroma may represent too
strong a barrier for the CD47 antibodies to reach the cancer
cells
..tumors in mice treated with both Abraxane and anti-CD47 mAbs
diminished in size, such that one tumor was completely eliminated,
and the remaining tumors failed to relapse

http://clincancerres.aacrjournals.org/content/21/10/2325.abstract