I've said it before, and it's a total guess, but I believe the volume is Sarissa purchasing additional shares.
As most will remember, Denner asked the Board to approve additional purchases when the Poison Pill was still in place. Foolishly, he was denied.
As an insider, his ability to purchase (or sell) is limited to periods when there is no material information known by him and not by the public. I believe even an SEC 1b5-1 Plan can only be initiated when material info. hasn't been disclosed. Often times this "non-blackout period" is the two or three weeks following an earnings release.
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