Tuesday, February 23, 2016 10:14:20 PM
Thanks for the Wechsler slides (excellent review of this RDB trial to date) and its promising cost efficacy implications.
Also for your speculations on the buy/merger with Healios.
The clinical efficacy of the active ingredient was NOT zero, it;s efficacy was clinically substantial at 90 days,but it was NOT STAT. significantly superior to the the placebo group at 90 days.
A DELAYED biological mechanism of clinical efficacy onset(Yamanaka 2012) may be implicated in the paradoxical stat.sig increased efficacy(p=0.01) at 365 days, on several measures of theoretical and clinically significant outcome.
This DELAYED onset mechanism requires replication,but is not inconsistent with biological theory.
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