Enanta Pharmaceuticals Inc (ENTA)

[NY1972]

Comparing Cyclophilin A and miR-122

CyPA is involved in diverse pathological processes of cancer development. Specifically, it has been reported that overexpressed CyPA in many cancers: (1) helps cancer proliferation,73 (2) regulates cell cycle progression,74 (3) blocks apoptosis,75 and (4) promotes cell migration/invasion.76


http://www.nature.com/cddis/journal/v4/n10/full/cddis2013410a.html


miR-122 levels are frequently reduced in hepatocellular carcinoma (HCC) compared to normal liver, and low miR-122 levels correlate with poor prognosis.[15][16] Overexpression of miR-122 reduces tumorigenic properties in HCC cell lines, suggesting that it functions as a tumor suppressor gene, and increases the response of cells to the chemotherapeutic drugs sorafenib and doxorubicin.

https://en.wikipedia.org/wiki/MiR-122#Role_in_cancer