Innovation Pharmaceuticals Inc (IPIX)

[Waverunner1]

I think this part is exactly right -

Checkpoint inhibitors really help immune system to attack the cancer cells - the mAb based drugs help to identify the cancer cells so T cells can attack them

These drug really do not address the cause of cancer ie break in cell death cycle which leads to growth /creation of new cancer cells but address the symptom ie killing already grown tumor cells

K is really trying to address the cause of tumor cells ie by activating the cell death cycle by activating P53 (which is damaged or mutated)

So if K really works - it will stop the tumor cycle and new cancer cells will not be created. (Cancer stabilization)

I think that if Kevetrin works the way we think it does then P53 repair/restoration may restore normal functioning of the immune system, at least as far as it relates to the all-important PD-L1 pathway. If that is the case then with the brakes off the immune system, it would mop up any remnants of disease with no other treatments necessary. Are there other immune checkpoints that might be affected as well? I think the odds of that are very good with P-53 being so fundamental to the process. Massive potential, a lot of questions still to be answered.

Then question remains is - even when K works, what will happen to all cancer cells in the tumor -it may need chemo-radiation or immunotherapy