Sunday, February 07, 2016 9:37:54 AM
Frrol - thanks - you are right
Here is my understanding -
Checkpoint inhibitors really help immune system to attack the cancer cells - the mAb based drugs help to identify the cancer cells so T cells can attack them
These drug really do not address the cause of cancer ie break in cell death cycle which leads to growth /creation of new cancer cells but address the symptom ie killing already grown tumor cells
K is really trying to address the cause of tumor cells ie by activating the cell death cycle by activating P53 (which is damaged or mutated)
So if K really works - it will stop the tumor cycle and new cancer cells will not be created. (Cancer stabilization)
Then question remains is - even when K works, what will happen to all cancer cells in the tumor -it may need chemo-radiation or immunotherapy
Hopefully DF and Mayo can get some answers
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