Friday, January 29, 2016 2:10:58 PM
http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20151222&CC=BR&NR=PI0912277A2&KC=A2#
Filed 12/22/15
The invention allows for the production of oligosaccharide structures, e.g., a decasaccharide, having defined structure and/or properties. The invention provides for oligosaccharide drugs and drug candidates, e.g., drugs or drug candidates having a desired biological property, e.g., anti-factor Ha activity, anti-factor Xa activity, antithrombotic activity, anti-inflammatory activity, anti-angiogenic activity, anti-cancer or anti -metastatic activity. Preparations of the oligosaccharides, e.g., preparations of oligosaccharide drugs, can have optimized heterogeneity and can, e.g., be less heterogeneous than oligosaccharide drugs prepared from natural sources. The invention also provides libraries and other constructs useful for the production of oligosaccharides.
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