Avid Bioservices Inc (CDMO)

[biopharm]

..all those "phospathtidylserine exposure' variations.

It finally starts to demonstrate what we have been posting for years now:

EVERYWHERE where something goes wrong involving cell's PS gets exposed and suppresses the immune system resulting in SOME consequences depending on the cause.

- Cut cells (accident, crime, war, surgery) and PS gets exposed.
- Viral intrusion and PS gets exposed
- Inflammations and PS gets exposed
- Tumours and PS gets exposed
- Chemo, Radio therapy cell damage and massive PS gets exposed
- etc.

And there clearly must be a CRITICAL MASS of it because if, for instance with Bavituximab, you manage to partially bind it and reduced it amount there is a point where macrophages and MDSC's are no longer suppressed from secreting the substances that activate the immune system.

Hence again, PS intake via food (soya incl. soya lecithin, white beans and organic meat, etc) can best be avoided during treatment because it increases the amount of PS to be blocked by binding.

The articles you are posting in that area now clearly show that this theory of PS involved in many more instances then PPHM spoke of in the beginning was correct.

And this confirms Bavituximab's broad potential not making it easy to acquire with catching class action for undervalue.

------------------------------------------------

CP, I found another very interesting link that details, again, the intense interest re: exposure of Phosphatidylserine...

I only ask most people reading this to pay attention and read slowly this post and link below, even if you do not understand it the first go around, but by the time you reach slide# 19-25 it should start to become very clear why maybe someone decided they MUST attempt a sabotage upon clinical trials --> towards Peregrine Pharmaceuticals.

--------------------------------------------------

Transient Plasma: Energy, Engines, and Aerospace Applications

Transient plasma occurs during the formative phase prior to equilibration of the electron energy distribution. It is studied for applications to engine efficiency and other diverse areas. Ideas for future directions will be presented.

Research supported by the AFOSR, ONR, Nissan, NumerEx/ONR STTR, Ness/AF STTR, NIH, NSF, TCC Corp., WPAFRL, Alfred Mann Inst

Transient Plasma Overview:

Summary, Areas for Research

•nsec Pulser-driven ignition
•Intrinsic Efficiency Advantages
•Pulse Detonation Engine
•ICE (Internal Combustion Engines)
•New Directions for Engine Research
•High pressure Studies (Diesel, natural gas)
•Role of non-equilibrium
electrons – USC streamer studies
•LIF, modeling (incl. work with NPS, WPAFRL, NumerEx)
•Compact pulser status
–Volume weight reduction
•More Directions for Future Work

....
...

Slide: 19 Pulsed Power USC Bio-Medical Research with Nanosecond Plasma and Electric Fields
..
..
Cancer: in vitro studies–Phosphatidylserine
inversion
–localized, experiment, simulation
•Cancer: in vivo studies
–mice – human pancreatic cancer tumors
–Human basil cell carcinoma



collaborators:

Thomas Chen
KSoM Neurology

Christin Chong
ug, biology

Cheryl Craft
KSoM

Edward Garon
MD, UCLA

Phil Koeffler
Cedars, UCLA, MD

Andras Kuthi
Res. Sci.

Aimin Li
Post doc, medicine

Laura Marcu
UC Davis

David Sawcer
KSoM Dermatology

Yinghua Sun
Grad student Mat Sci

Tao Tang
Grad student EE

Miguel Valderrabano
DeBakey cardiology

Tom Vernier
Res. Assoc Prof. USC

Multidisciplinary collaboration disciplines:
Electrical Engineering, Chemical Engineering and Materials Science, Medicine, Biology, Cancer and Oncology, Biomedical
Engineering.

UNITS: Viterbi School of Engineering, Cedars-
Sinai Research Center, ISI-MOSIS, Keck School of Medicine, College of Letters Arts and Science

https://www.princeton.edu/mae/people/faculty/miles/atmospheric-pressure-08-1/EnergyGundersen_apwip.pdf


----------------------------------------


Hopefully now, everyone is in the PS Targeting comfort zone and realize big things are coming and yes, I do believe the Presidents Council will be watching closely... especially since we are talking about disruptions and paradigm shifts in more sectors than just biotech...

Eric Schmidt sits on that Presidents Council and just gives me some slight hope that CALICO could be passed Billions of $$$ from Google (now Alphabet) to pursue this, but it looks like Pfizer is all of a sudden the #1 market cap Big Pharma...unless Eric Schmidt decides to move in with at least a major investment into Peregrine Pharmaceuticals.

https://www.whitehouse.gov/administration/eop/ostp/pcast/about/members

John P. Holdren

Eric Lander

William Press

Maxine Savitz

Wanda M. Austin

Rosina Bierbaum

Christine Cassel

Christopher Chyba

S. James Gates, Jr.

Mark Gorenberg

Susan L. Graham

J. Michael McQuade

Chad Mirkin

Mario J. Molina

Craig Mundie

Ed Penhoet

Barbara Schaal

Eric Schmidt

Daniel Schrag

--------------------------------------

I'll stop here on another long winded post, but if this Princeton<>DARPA link gives devotes 7 slides out of 25 (19-25) and PS Targeting is part of it.... maybe DARPA is sneaking around with Peregrine Pharmaceuticals.

I still look forward for the day that Peregrine has access to several FDA vouchers and maybe more... heck they can raise money simply by selling off vouchers left and right, because no matter whom they sell them to they will require PS Targeting !! : )

Mr. Lytle, we need Avid IV funds by next month...

No Problem, we can sell this FDA voucher sitting around for $1 Billion to Roche. It looks like they are looking to beat XYZ to the punch for this next blockbuster drug : )