Avid Bioservices Inc (CDMO)

[Threes]

I could also lead to the opposite.
A percentage of patients precluded because they are PD negative will be flipped to become Pd positive from Bavi..

If confirmed as the research to this point indicates Bavi changes the macro environment and therefore PD negative to positive.

The test may reveal which patients must first go on a regime with Bavi then retested to determine if they can be prescribed PD, regardless of which , Ketruda, Opdivo, etc etc. The still negative PD patients then would be prescribed Chemo or irradiation.

Also remember the side effects are severe so up 40 % of the population prescribed will not tolerate the PD platform and for those it's back to Chemo, irradiation, which by the way will still require bavi from optimum results and reduced side effects as well as remember the longer lasting remissions and possible CR's.

The latter, long term remission and CR's I have high hopes for in BC, considering the 85 % response rates we have seen for that indication with CR's from the previous trial.