Avid Bioservices Inc (CDMO)

[biopharm]

GILD has the profile to be such a potential company for PPHM.
100$ per share + 3 GILD shares? approx 100$+3x120$=460$ ?

That is about 40% of GILDs outstanding shares and equally dared as their previous acquisition. But they get the BIGGEST POTENTIAL EVER in return.
And what GILD needs is POTENTIAL that they can LEVERAGE, not pay for regular income where growth depends only on sales & marketing. With Bavi there is a complete platform to drive growth.

I am SURE GILD would make money on that in less then 5 years.
And GILD would never do the bleed that they would do in cash for a BYM or so.

CP or Sunstar...or whomever wants to take a shot at this one: what do you think of this patent filed by Gilead just after our Sept 2012 sabotage and is it them just trying to gain some leverage, knowing PS Targeting is the key ?

Phosphatidylinositol 3-kinase inhibitors

Publication number US9018221 B2
Publication type Grant
Application number US 14/137,978
Publication date Apr 28, 2015
Filing date Dec 20, 2013
Priority date Dec 21, 2012
Also published as CA2895782A1, US20140179673, US20150218154, WO2014100765A1
Inventors Jerry Evarts, Leena PATEL, Jennifer A. TREIBERG, Stephane Perreault, Arthur Yeung, J. Purvis II Lafe, Musong Kim, Less «
Original Assignee Gilead Calistoga, Llc


Cell signaling via 3'-phosphorylated phosphoinositides has been implicated in a variety of cellular processes, e.g., malignant transformation, growth factor signaling, inflammation, and immunity. See generally Rameh et al., J. Biol. Chem., 274:8347-8350 (1999). The enzyme responsible for generating these phosphorylated signaling products is phosphatidylinositol 3-kinase (PI 3-kinase; PI3K). PI3K originally was identified as an activity associated with viral oncoproteins and growth factor receptor tyrosine kinases that phosphorylate phosphatidylinositol (PI) and its phosphorylated derivatives at the 3'-hydroxyl of the inositol ring. See Panayotou et al., Trends Cell Biol 2:358-60 (1992).

Presently, three classes of the PI 3-kinase (PI3K) enzymes are distinguished, based on their substrate specificities. Class I PI3Ks can phosphorylate phosphatidylinositol (PI), phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-biphosphate (PIP2) to produce phosphatidylinositol-3-phosphate (PIP), phosphatidylinositol-3,4-biphosphate, and phosphatidylinositol-3,4,5-triphosphate, respectively. Class II PI3Ks phosphorylate PI and phosphatidylinositol-4-phosphate, whereas Class III PI3Ks can only phosphorylate PI.

The initial purification and molecular cloning of PI 3-kinase revealed that it was a heterodimer consisting of p85 and p110 subunits. See Otsu et al., Cell, 65:91-104 (1991); Hiles et al., Cell, 70:419-29 (1992). Since then, four distinct Class I PI3Ks have been identified

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http://www.google.com/patents/US9018221