On the trading floor, shares of AEterna Zentaris Inc. (USA) (NASDAQ:AEZS) gained 1.67% to close at $0.189. The company on July 29, 2015 declared it has selected an optimized Erk inhibitor molecule for development, thus achieving another important milestone in the development of a new class of potential cancer therapies.
The MAPK pathway represents a prime target for therapeutic intervention in cancer. Recently approved compounds demonstrate important antitumor activities and survival benefits for B-Raf and Mek inhibitors. Erk inhibitors may be preferred agents in tumors with aberrant MAPK pathway activity, e.g. in tumors with mutated or wildtype B-Raf, mutated or wildtype ras, and in tumors with acquired resistance to Raf and Mek inhibitors.
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