Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

Turn Off Your Body's Aging "Switch" in 'Pro Health', Morris Eagleton • www.ProHealth.com • July 29, 2015

Excerpts:
"How HMGB1 Triggers Inflammation

The molecule HMGB1 is responsible for initiating acute inflammation, which is a helpful reaction when your body is under attack by germs, or following an injury.5,6 Unfortunately, when a cell is damaged, its contents of HMGB1 leak out, leading to chronic inflammation.5,6

When HMGB1 leaks out, it acts as a "danger signal" that triggers the release of chemical signaling molecules (called cytokines) that call in more white blood cells, which release still more cytokines, in a vicious cycle."

"Laboratory experiments have demonstrated that putting the brakes on HMGB1 is a powerful means of slowing and reversing the processes involved in inflammation.3,4 In fact, scientists are examining the role of HMGB1 in the body and are using experimental models to begin making strides in the fight against inflammation in asthma, rheumatoid arthritis, diabetes, multiple sclerosis, and inflammatory bowel diseases.12-20

Big Pharma is frantically working to create treatments that target HMGB1, but at this point no anti-HMGB1 drug is anywhere near market-ready."

"Summary

Chronic inflammation accelerates aging and is an underlying factor in many of the diseases associated with aging.1,2,34 Scientists have discovered a way to inhibit HMGB1, the molecule that "turns on" the release of inflammatory cytokines.3-6,24

Mung beans and green tea have been in use for thousands of years in traditional Chinese medicine.3,4 They both contain powerful substances that inhibit HMGB1. Lab studies have proven that these substances are highly effective at "turning off" the HMGB1 switch that induces chronic inflammation.3,4,24

Mung bean seed coat extract and EGCG are available in oral form, making their combined HMGB1-blocking effect convenient to take by mouth."

Article at:
http://www.prohealth.com/library/showarticle.cfm?libid=20896