Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

Link between inflammation and cancer in'Genetic Literacy Project',
Ben Locwin, July 29, 2015

Excerpts:
"New research from MIT gives further evidence that inflammation is related to cancerous processes. But that alone isn’t the whole story – the study authors found reason why inflammatory processes drive the development of cancer, and how the effect seems to also relate to the timing of exposure. The senior researcher in the finding observed, “…you do get synergy between cell division and inflammation-induced DNA damage, but in these studies there was only a mutation risk if there is chronic or repeated inflammatory responses.”

What this means is that inflammatory processes will often be accompanied by DNA damage; Now if the body has sufficient time between inflammatory bouts, it can most often repair the damaged DNA without mutations and abnormal cell growth occurring, which precedes cancerous proliferation. But if the periods are more chronic or with less time in-between, the proliferating cells, which are more susceptible to DNA damage, can be adversely affected. Another major factor the researchers looked at was the presence of DNA-alkylating agents during cell division. Alkylating agents are used in a variety of products that we are frequently exposed to.

As above, in small doses periodically spaced, the body’s DNA repair mechanisms are able to efficiently contend with the damage. However, in inflamed tissues exposed to alkylating agents, the alkylated DNA bases became too overwhelming, and cell mutations were detected that could cause cells to become cancerous. Extending this logic as the authors did would mean that individuals who were experiencing inflammation of some sort, or with a chronic inflammatory condition, would be more susceptible to DNA-induced cell mutations contributed by carcinogenic cofactors."

Article at:
http://www.geneticliteracyproject.org/2015/07/29/link-between-inflammation-and-cancer/