Friday, May 22, 2015 6:46:06 AM
CD8
http://en.wikipedia.org/wiki/CD8
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein.[2] There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12.
TILs
http://en.wikipedia.org/wiki/Tumor-infiltrating_lymphocytes
Tumor infiltrating lymphocytes (TILs) are a type of white blood cell found in tumors. TILs are implicated in killing tumor cells, and the presence of lymphocytes in tumors is often associated with better clinical outcomes
$ONCS pursuit of optimizing CD8 TILs via identification markers could possibly lead to increased ORR of EP+IL-12 varied dosages specific for each individual Cancer recipient.
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