Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

BINGO!---"In this article we make the case for the role of glia in the pathophysiology of delirium and describe an astrocyte-dependent central and peripheral cholinergic anti-inflammatory shield which may be disabled by astrocytic pathology, leading to neuroinflammation and delirium."


Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation.
Paris D1, Beaulieu-Abdelahad D, Abdullah L, Bachmeier C, Ait-Ghezala G, Reed J, Verma M, Crawford F, Mullan M.

"Previous investigations have demonstrated the anti-inflammatory effects of cholinergic agonists, such as nicotine. In the present study, we investigated the potential anti-inflammatory activity of anatabine, a minor tobacco alkaloid also present in plants of the Solanacea family which displays a chemical structural similarity with nicotine."

Article at:
http://www.ncbi.nlm.nih.gov/pubmed/23178521