CBDHealthSolutions.com "Canna Joos" review; CBD-oil research I tried the Canna Joos yesterday. Here is my review for the board as promised:
First a little background: I was so excited to get my order (placed Friday afternoon), which was split (for my convenience since Flakes aren't out til tomorrow) into separate shipments of Joos and Flakes. Excellent customer service, expedient, and it included a tracking number from USPS.
So, as I spammed the refresh button on the tracker site, it suddenly said "delivered in the mailbox". It was Monday at about 12:30pm when I went out to fetch my order. I had previously considered the possibility that inducing a state of relaxation may not be wise while trading but I thought the effect would be rather transient. I took half of a "Serving" which is defined on the bottle as a "Full dropper (approx. 1mL)" sublingually. I held it under my tongue for 90 seconds before swallowing it.
My experience: (hours:minutes) Note: Supplements/drugs tend to have very strong effects on me. I also take some nootropics (piracetam + Alpha GPC) which will certainly exacerbate the effect of drugs. T-0:00 It tasted pretty good, not awesome, but it was fine. "Citrus Blend" has a kind of orange and orange rind flavor. T-0:01 My mouth started to feel a bit numb. I'm not sure if it was the oil saturating and desensitizing my nerves or an analgesic effect but I am leaning towards the latter. T-0:05 I first notice a change in my vision. Over the next hour this transformed into an almost dream-like dissociation with my field of vision. T-0:10 My arms and legs are starting to feel heavier. I feel very comfortable kind of slouching into my chair. T-0:30 I am definitely feeling relaxed, with notably reduced heart rate and breathing rate, and the effect continues to grow stronger. T-1:00 As I walk around, I feel as if I'm kind of just drifting along albeit a bit clumsy and less coordinated than usual. T-1:10 I take a gander in the mirror and notice my pupils are tiny. I feel relaxed, almost withdrawn from my surroundings. T-2:00 The plateau happens around this point give or take 15 minutes. T-3:00 The effect slowly wore off leaving me quite calm and with some residual lethargy eventually subsiding.
Conclusion: I am very surprised by the potency of the Canna Joos. I've had several tinctures which had far less-noticeable effects. Personally, the suggested serving size is rather large; I'm glad that I didn't take more on the first try. For new users: I would recommend a test-run with 1/3-1/2 of a dropper. While I enjoyed the strong, relaxing effect and expect to use Canna Joos regularly, I will be wiser and carefully select appropriate occasions before use. I can say with certainty that this is not conducive to day trading!
It was interesting to read about SSRI drugs, how they affect the 5-HT(1A) & 5-HT(2A) autoreceptors and compare/contrast the effect of CBD (which is an agonist for them) but impacts serotonin expression differently. At first, I was slightly concerned - mostly curious - about how the brain adapts to consistent use of CBD oil (like THC) via down-regulation or up-regulation of certain neural pathways/processes including the receptor densities of CB1-CB4+ receptors and the aforementioned autoreceptors. After doing some preliminary research, I believe it is healthier for the normal person than it is bad. On the other hand, it obviously make sense for someone who uses it medicinally.
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Actually, thinking about it, since the half life of cannabidiol (CBD) is long (around 2 to 5 days, ref: here), once you start taking the CBD oil daily, CBD is going to be in your system at fairly constant levels, no matter what time you take your CBD oil.
Low dose naltrexone (LDN), by contrast, will have left your body within 2 or 3 of taking it. So only for a few hours after taking LDN will you have opioid receptor antagonism from naltrexone.
But of course after those 2 or 3 hours are over, although the opioid receptor antagonism will have ended as the naltrexone leaves your body, you will have higher levels of the opioid met-enkephalin in your body, because the effect of LDN is to create higher levels of met-enkephalin.
So this means you initially have opioid receptor antagonism with LDN, for 2 or 3 hours, then followed by increased opioid receptor agonism (activation) for the rest of the day, due to the higher levels of met-enkephalin in circulation in the body.
If we are talking about the effects of marijuana and tetrahydrocannabinol (THC), then it seems that opioid receptor antagonism from LDN will enhance the effects of marijuana and THC:
• This study found that opioid antagonism from naltrexone enhances the effects of marijuana: naltrexone increases the subjective "high" that users feel from marijuana, and increases the cardiovascular effects of marijuana. Note that marijuana contains both THC and CBD.
• This study also found that ultra low dose naltrexone enhances the pain-relieving effects of THC-like cannabinoids; this study employed a synthetic cannabinoid called WIN 55,212-2, which like THC, agonizes the CB1 and CB2 cannabinoid receptors.
? However, CBD is not THC, so the above studies do not apply to CBD. When it comes to CBD, things seem more complicated:
Unlike THC, CBD has a very low affinity for the CB1 and CB2 cannabinoid receptors. Rather, CBD acts as an indirect antagonist of the agonist effects of THC-like cannabinoids. In other words, CBD can reduce THC's activation of the cannabinoid receptors. This is according to the Wikipedia article on CBD, which is worth looking at: Cannabidiol - Wikipedia.
Though Wikipedia also says: one would assume that CBD would reduce the effects of THC, but in fact CBD may potentiate THC's effects by increasing CB1 receptor density. So it seems that there is no clear indication on whether CBD blocks or potentiates the effects of cannabinoids like THC. It probably does a bit of both.
Likewise, I guess it therefore is not clear whether CBD may block or potentiate the effects of the body's own natural cannabinoids — the endocannabinoids — on the cannabinoid receptors. These endocannabinoids are involved in appetite, pain-sensation, mood and memory.
It is therefore not very clear how CBD works at the cannabinoid receptors: it seems to have both THC enhancing and THC reducing effects.
So as for any attempt at a theoretical understanding of the interaction between LDN and CBD, it is all about a clear as mud!
I would just stick with your own empirical observation that LDN reduces the effects of CBD, and go with that.
? Note that in addition to its effects at the cannabinoid receptors, CBD is also a 5-HT1A serotonin receptor agonist, which apparently relates to CBD's antidepressant, anxiolytic and neuroprotective effects. The Wikipedia article on the 5-HT1A receptor says that the effects of activating this receptor include:
Relieving anxiety and depression Decreased aggression Increased sociability Decreased impulsivity Facilitation of sex drive and arousal Inhibition of penile erection Diminished food intake Prolongation of REM sleep latency Improving cognitive functions associated with the prefrontal cortex Improving symptoms of schizophrenia and Parkinson's
In ME/CFS, it has been found that there are 5-HT1A receptor abnormalities. Perhaps CBD oil might help rectify these abnormalities?
? CBD is in addition a partial agonist of the 5-HT2A serotonin receptor. Activation of this 5-HT2A receptor has potent anti-inflammatory effects: such activation reduces levels of the inflammatory cytokine TNF-alpha (ref: here).
Activation of the 5-HT2A receptor also causes a release of oxytocin (the love and human bonding hormone), which might explain why Cannabis tends to make people more friendly.
Both the 5-HT1A and 5-HT2A receptors are known to mediate spiritual effects — see this study: Self-Transcendence as a Measurable Transpersonal Construct Albert Garcia-Romeu, The Journal of Transpersonal Psychology, 2010, Vol. 42, No. 1
Interestingly, many psychedelic drugs such as LSD and psilocybin activate both 5-HT1A and 5-HT2A, though most of the effects of these psychedelics is mediated by the 5-HT2A receptor.
One important point that should be noted by those trying out CBD oil: CBD is observed to have a bell-shaped dose-response curve (ref: here). This means that up to a certain point, increasing your CBD dose will increase its effects; but then after you get to the optimum dosage, further increases in CBD dose will actually result in reduced effects.
