Benitec Biopharma Ltd (BNTC)

[georgejjl]

Per Dr. David Suhy:

Transduction levels roughly consistent with pre-clinical studies: QPCR analysis:
• Subject 1 cohort 1 (4e10 vg/kg): 0.02 copies TT-034 per cell (average)
• Subject 2 cohort 1 (4e10 vg/kg): 0.01 copies TT-034 per cell (average)
• Subject 1 cohort 2 (1.25e11 vg/kg): 0.48 copies TT-034 per cell (average)

If consistent with pre-clinical studies, cohort 3 may have significantly higher percentage of DNA transduction


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After reviewing the data available, I now believe that it may be quite possible and even probable to completely eliminate the Hepatits C viral load for subjects treated at the 3rd dose cohort and it may be unnecessary to increase the dose leve beyond the dose of the 3rd dose cohort.

Good luck and GOD bless,

George