Saturday, May 02, 2015 9:10:21 PM
"Concerns have been raised that a widespread use of HDPs in the clinic would select for pathogens resistant to natural immune defences. Indeed, many bacterial species already possess modestly effective resistance mechanisms, including peptide degradation, sequestration, efflux, and chemical modifications of cell walls and membranes to reduce HDP binding; resistance to HDPs can be selected in the laboratory."
Nonetheless HDP mimetics are an improvement over all other classes in anti-resistance.
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