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Sunday, 04/26/2015 7:26:46 PM

Sunday, April 26, 2015 7:26:46 PM

Post# of 402726
More on why HDP-Ms may be a good target for GI conditions (Chron's, Ulcerative Colitis, IBD)-----anti-inflammatory, anti-bacterial properties... B already active against E. coli, C. difficile.

Good to see the gram- deck. Thx Karin. Looks like solid coverage w/ the lead compound w/ addtl compounds and tweaking to come. Welcome back a-17.

Btw, I wouldn't be surprised to see a PR tmrw -- like Miles Teg thinks. Prob wrong, just a gut feel.

And for the Dune fans - a new collectors edition maybe worth picking up. Some quotes reflecting our yo-yo Board of late.

"Hope clouds observation."
but also:
"Fear is the mind-killer."

Looking fwd to B and K and P continuing to progress into human trials... All three promising Sleepers awakening.

http://www.washingtonpost.com/entertainment/books/dune-receives-the-royal-treatment-on-its-50th-anniversary/2015/04/22/11caa9a2-e84f-11e4-aae1-d642717d8afa_story.html

///

http://m.gastroendonews.com/Article.aspx?d=Educational+Reviews&d_id=192&i=April+2015&i_id=1169&a_id=30964

"The Microbiome for Gastroenterologists"
Amit Dutta, MD
Aberdeen Royal Infirmary
Forsterhill, Aberdeen, United Kingdom
Emad M. El-Omar, MD, FRCP
Division of Applied Medicine
Institute of Medical Sciences
School of Medicine & Dentistry
Aberdeen University
Foresterhill, Aberdeen, United Kingdom

EXCERPT
Numerous studies have shown that the composition of gut bacteria in patients with Crohn’s disease and ulcerative colitis differs from that in healthy people.34,35There is reduction in Firmicutes and Bacteroides35; Faecalibacterium prausnitizi, a firmicute, has ***anti-inflammatory properties and has been shown to be reduced in in patients with IBD36***; and Proteobacteria and Actinobacteria are increased.37 Adherent invasive ***Escherichia coli were found in increased numbers in ileal biopsy specimens in patients with Crohn’s disease.38***

http://m.gastroendonews.com/Article.aspx?d=Educational+Reviews&d_id=192&i=April+2015&i_id=1169&a_id=30964
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