NorthWest Biotherapeutics Inc (NWBO)

[Pyrrhonian]

Those were not ePD flipper!

Patients who had shown either 25% increase (from slight residual tumor--see criteria) or any size new lesion (and that is the only possibility if they had total resection) at baseline, and who after being followed up 2 months later showed another 25% increase of that small residual tumor or 25% increase in the new lesion of indeterminate size, or stable residual or new lesion at month 2 but the appearance of another new lesion of indeterminate size (suddenly not sounding so crazy huh?), were labeled rapid progressors.

The "indeterminates" showed 25% increase (from slight residual tumor--see criteria) or any size new lesion at baseline, but who after being followed up 2 months later showed either regression of either or stable disease in either, or a little growth in either.

I said, well, if they scanned them again at 6 months like is often done in studies to determine psPD, then many of those indeterminates would no longer be indeterminate but properly split into ePD or psPD.

You said, no, because DCVax-L might cause those tumors to regress and so ePD would incorrectly be labeled as psPD.

I am saying I disagree because that just doesn't happen in ePD patients treated with DC vaccines, and I will now clarify further to say that it even rarely happens in any indication or stage of disease where bulky, fast progressing tumor masses are present.

But who cares about that point anyway, these data do not come from a randomized trial, so any claim of survival benefit is unsubstantiated.