Tuesday, March 24, 2015 4:39:52 PM
EAU15 - Poster: Among men with low-grade prostate cancer on prostate biopsy, the 4Kscore predicts the presence of more aggressive prostate cancer
Presented by S. Punnen, M. Steiner, S. Zappala, J. Palou, D. Sjoberg, V. Mathur, R. Roberts, V. Linder, M. Reeve, D. Okrongly, J. Newmark, G. Sant, J. Morote, and D. Parekh! at the 30th Annual European Association of Urology (EAU) Congress - March 20 - 24, 2015 - IFEMA - Feria de Madrid - Madrid, Spain
MADRID, SPAIN 23 March 2015 (UroToday.com) - The appropriate identification of men with truly low-grade, indolent prostate cancer is essential to minimize the potential for disease progression on active surveillance protocols. The 4Kscore is a blood test measuring the levels of 4 kallikrein biomarkers (total PSA, free PSA, intact PSA, and human kallikrein-2) which has been demonstrated to accurately predict an increased likelihood of high-grade disease on biopsy. In this study the authors looked more specifically at the ability of the 4Kscore to predict the presence of aggressive disease in patients with low-grade disease diagnosed on biopsy, who would thus be poor candidates for active surveillance. To achieve this purpose, the study looked at the rate of disease upgrading in patients with Gleason 6 disease on biopsy who ultimately underwent radical prostatectomy.
The final cohort of this study consisted of 306 patients recruited from October 2013 to April 2014 in a prospective multi-institution study. The authors reported that higher 4Kscores significantly correlated with increasing amounts of cancer detected on biopsy, as measured by positive core number and core length. Of the 51 men who ultimately underwent radical prostatectomy, patients whose disease was upgraded to a Gleason 7 disease or greater had a significantly higher pre-biopsy 4Kscore in comparison to those patients whose disease was not upgraded (15 vs 7 respectively, p=0.02).
The authors concluded that the 4Kscore may be utilized to better risk-stratify patients to active surveillance or immediate treatment. Further investigation will be necessary to determine the optimal use of the 4Kscore in this setting. The identification of specific cutoff levels for observation vs further investigation vs intervention could prove to provide a significant clinical benefit.
Presented by S. Punnen, M. Steiner, S. Zappala, J. Palou, D. Sjoberg, V. Mathur, R. Roberts, V. Linder, M. Reeve, D. Okrongly, J. Newmark, G. Sant, J. Morote, and D. Parekh! at the 30th Annual European Association of Urology (EAU) Congress - March 20 - 24, 2015 - IFEMA - Feria de Madrid - Madrid, Spain
Sylvester Comprehensive Cancer Center/University of Miami Health System, Miami, FL USA
4Kscore Session Image Poster
Recent OPK News
- OPKO Health’s ModeX Therapeutics Appoints Dr. Giovanni Abbadessa as Chief Medical Officer as Pipeline Advances into Clinical Development • GlobeNewswire Inc. • 09/23/2024 12:00:00 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 09/20/2024 06:56:10 PM
- Form SC 13D/A - General Statement of Acquisition of Beneficial Ownership: [Amend] • Edgar (US Regulatory) • 09/18/2024 08:13:05 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 09/16/2024 09:00:42 PM
- Labcorp Completes Acquisition of Select Assets of BioReference Health's Diagnostics Business from OPKO Health • PR Newswire (US) • 09/16/2024 11:30:00 AM
- Form DEFR14A - Revised definitive proxy soliciting materials • Edgar (US Regulatory) • 08/30/2024 09:01:33 PM
- Form SC 13D/A - General Statement of Acquisition of Beneficial Ownership: [Amend] • Edgar (US Regulatory) • 08/23/2024 09:33:46 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/19/2024 09:23:52 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/14/2024 08:50:25 PM
- Form SC 13D/A - General Statement of Acquisition of Beneficial Ownership: [Amend] • Edgar (US Regulatory) • 08/12/2024 10:27:05 PM
- Entera Bio Reports Q2 2024 Financial Results and Provides Business Updates • GlobeNewswire Inc. • 08/09/2024 08:05:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/08/2024 09:39:52 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/07/2024 08:12:45 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/07/2024 08:07:42 PM
- OPKO Health Reports Second Quarter 2024 Business Highlights and Financial Results • GlobeNewswire Inc. • 08/07/2024 08:06:35 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/02/2024 08:21:51 PM
- OPKO Health to Report Second Quarter 2024 Financial Results on August 7, 2024 • GlobeNewswire Inc. • 08/01/2024 08:05:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/31/2024 09:03:04 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/26/2024 11:49:22 PM
- Form SC 13D/A - General Statement of Acquisition of Beneficial Ownership: [Amend] • Edgar (US Regulatory) • 07/26/2024 11:43:51 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/26/2024 11:18:18 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/26/2024 11:15:29 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/26/2024 11:11:51 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/26/2024 11:08:16 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/26/2024 11:05:39 PM
VHAI - Vocodia Partners with Leading Political Super PACs to Revolutionize Fundraising Efforts • VHAI • Sep 19, 2024 11:48 AM
Dear Cashmere Group Holding Co. AKA Swifty Global Signs Binding Letter of Intent to be Acquired by Signing Day Sports • DRCR • Sep 19, 2024 10:26 AM
HealthLynked Launches Virtual Urgent Care Through Partnership with Lyric Health. • HLYK • Sep 19, 2024 8:00 AM
Element79 Gold Corp. Appoints Kevin Arias as Advisor to the Board of Directors, Strengthening Strategic Leadership • ELMGF • Sep 18, 2024 10:29 AM
Mawson Finland Limited Further Expands the Known Mineralized Zones at Rajapalot: Palokas step-out drills 7 metres @ 9.1 g/t gold & 706 ppm cobalt • MFL • Sep 17, 2024 9:02 AM
PickleJar Announces Integration With OptCulture to Deliver Holistic Fan Experiences at Venue Point of Sale • PKLE • Sep 17, 2024 8:00 AM