Avid Bioservices Inc (CDMO)

[biopharm]

to take that possible collaboration further, Greg Lemke is one of the researchers whom has been studying PtdSer (Phosphatidylserine or PS) for quite some time... and noticed this below. At the beginning Lemke (Salk Institute) sort of made it sound as if they discovered PtdSer.... and never gave any claim to the late Dr. Philip Thorpe for all his foundation work that it was built on.

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Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells


I Dransfield1,3, A Zagórska2,3, E D Lew2, K Michail1 and G Lemke2

1MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK
2Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA, USA..
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Here we investigate the role of the receptor tyrosine kinase (RTK) Mer and its ligands Protein S and Gas6 in the initial recognition and capture of apoptotic cells (ACs) by macrophages. We demonstrate extremely rapid binding kinetics of both ligands to phosphatidylserine (PtdSer)-displaying ACs, and show that ACs can be co-opsonized with multiple PtdSer opsonins.
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http://www.nature.com/cddis/journal/v6/n2/abs/cddis201518a.html

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We are particularly interested in the role that dysregulation of the TAM signaling network plays in (a) the development of autoimmune diseases such as Lupus, Multiple Sclerosis, and Rheumatoid Arthritis, and (b) the course of infection by influenza, West Nile, and Dengue viruses.

http://www.salk.edu/faculty/lemke.html

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I'm used to relating TAM to "Tumor Associated Macrophages" .... but its different here...

The systems biology of the TAM (Tyro3, Axl, and Mer) RTKs in the immune and nervous systems is a major project focus of the lab.
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http://www.lemkelab.org/index.php?option=com_content&view=article&id=46&Itemid=67

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...and lets not forget for those who have not seen this re: Global BioDefense

Salk Institute Findings May Lead to New Broad-Spectrum Antivirals

August 19, 2013

The Salk scientists found that a substance called phosphatidylserine (PtdSer), which is found on the surface of enveloped viruses (viruses with an outer wrapping of a lipid membrane), binds to extracellular proteins and activates TAM receptors on immune cells. In dendritic cells, a type of immune cell that interacts with T and B cells to initiate the adaptive immune response, TAM receptor activation turns off a set of genes called interferons that play a key role in antiviral defense. -

http://globalbiodefense.com/2013/08/19/salk-institute-findings-may-lead-to-new-broad-spectrum-antivirals/

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