Monday, March 16, 2015 5:08:44 PM
The following was posted along with similar articles - last month
Based on extensive characterization of the mechanism of action of IVIg, both in animal models and in humans, we rationally designed a series of recombinant drug candidates with the potential to deliver improved therapeutic benefit compared to IVIg. These agents are termed Selective Immunodulators of Fc Receptors (SIF’s), and they selectively modulate the activity of members of the Fcg receptor family. In cell and animal models of immune-complex-mediated autoimmunity, SIF’s display up to 500-fold greater potency than IVIg.
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=110893983&txt2find=tony
CW - I will point out that in IVIg sales there is $3 billion to $4 billion of sales in these indications so we are going after here.
The preclinical data on those looks outstanding in terms of the potency that we can get versus IVIg. So it actually – what our goal here is to actually replace IVIg with a recombinant molecule get it out of the plasma supply chain and dramatically reduce the dose required. So you don’t have to have all-day doing that you have to have with IVIg in these diseases. So we are quite optimistic that there is a big opportunity for this molecule and now we’re moving to clinic as expeditiously as possible.
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=111337893&txt2find=ivig
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