Innovation Pharmaceuticals Inc (IPIX)

[slcimmuno]

Brilacidin (and Platform) vs Triclosan
Minotaur posted some good stuff earlier showing how the FDA is paying more attn to the ubiquitous Triclosan..... pretty much in everything, everywhere... and possibly not as effective (and less safe) than originally thought.

Below is a link to the full Tufts study on Triclosan showing how commonplace it is.
http://www.tufts.edu/med/apua/consumers/personal_home_21_4240495089.pdf

An exciting Vision of the Future (should the efficacy/safety profile of PYMX compounds continue to prove out, pass muster w/ the FDA)--a global "search and replace" with B substituting for T in the following products: soaps, handwashes, dish-washing products, laundry detergents and softeners, plastics (e.g., toys, cutting boards, kitchen utensils), toothpaste and mouth washes, deodorants and antiperspirants, cosmetics and shaving creams, acne treatment products, hair conditioners, bedding, trash bags, apparel like socks and undershirts, hot tubs, plastic lawn furniture, impregnated sponges, surgical scrubs, implantable medical devices, pesticides. (Note: the Tufts study also provides a list of Brands with Triclosan in them)

Related (ref'd earlier): PYMX did a study on sutures showed how suture coatings containing the PolyCide (PMX-50003) outperformed "coatings containing similar concentrations of triclosan in terms of bacterial killing. Ineffective killing was observed with triclosan coatings, whereas greater than 99% reductions in bacterial numbers were demonstrated with coatings containing 1.6% to 2.4% by weight of the PolyCide."

Landekic was quoted as saying "The compound [Brilacidin et al] has yet to meet a bug it can’t kill." Which, again, is backed up by fact... various PYMX research, Landekic nuggest from the transcripts, QIDP designation for B-ABSSSI (M-ITT data on MRSA), and hopefully for B-OM, with more applications and accelerated paths to approval to come.

Suture Study Overview
http://globenewswire.com/news-release/2012/09/05/488925/10004018/en/Data-Showing-Effectiveness-of-PolyCide-Antimicrobial-in-Surgical-Suture-Coatings-Published-in-American-Chemical-Society-Journal-Langmuir.html

2012 PYMX Suture Study in Full (PDF)
http://1drv.ms/1vpe0Q8

Last, came across this patent related to Sutures and Antimicrobrial Properties... looks like it has not been approved, and there is an interesting reference to Polymedix research on polymers, suggesting perhaps PYMX got there first.

Patent
http://www.google.com/patents/US20120041483

Reference to PYMX
[0011] Additionally, a company named Polymedix has developed an antimicrobial suture, for which they recently received a funding grant. The Polymedix suture employs Poly Cide polymers, that are described as "novel defensinminetic compounds," that are described as synthetic mimetics of the host offense proteins, that, (according to Polymedix) are one of the oldest and most effective antimicrobial defense systems found in humans and virtually all living creatures. These Poly Cides are alleged to have a mechanism of action that directly disrupts the bacterial cell membranes, that makes the development of bacterial resistence unlikely to occur. More information about these sutures can be found on www.polymedix.com. See Polymecix Press Release dated 11 Jun. 2010 "New Grant Supports Development of Antimicrobial Sutures to Combat Infection". See http://www.newswise.com/articles. No admission or position is taken as to whether the Polemedix compounds constitute prior art to the instant invention.

Glad people are finding info I'm posting useful. Finally feel like I'm pulling some weight on this Board.