Innovation Pharmaceuticals Inc (IPIX)

[BonelessCat]

I'm not distorting anything. You keep claiming facts and think but then ignore all evidence that shows something different from your thesis. Yes, in a simple scaling conversion, the mouse studies had doses exceeding the current dose of 350mg/m2. I never said otherwise. But, in 3 different academic papers and a source page from the NIH I showed that those levels in the mouse studies cannot be counted on as accurate. In fact one source showed that the conversion you use is more than unreliable, it is misleading. Then you ignore the statements of Dr Menon who said he expected efficacy at half the current dose in addition to ignoring the meaning of the statement in the last PR that they are designing a Phase 2/3 trial.

Here's the thing: They can't design a phase 2/3 trial for a combination because they have to prove safety first which includes a new dose escalation and a new PK/PD for the drug in combination. Phase 2/3 can only be for a mono-therapy, period, which can only be approved if there is tumor shrinkage, lesion closing, AND pain relief. Emphasis on "and."

Bottom line here, all evidence points to 1) tumor shrinkage against at least on Cancer type, 2) at a much lower dosage than the mouse study conversion would have us believe, 3) in the case of K simple scaling conversion is indeed misleading, and 4) we will have all the answers in 6 months and those answers will be which tumor types and not if.