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Cytori Announces Promising Results in a Feasibility Trial of Cytori Cell Therapy in Conjunction with Anterior Cruciate Ligament Repair
8:00a ET November 21, 2014 (Business Wire) Print
Cytori Therapeutics, Inc. (NASDAQ: CYTX) today reported positive results from a clinical study of Cytori Cell Therapy(TM) in anterior cruciate ligament (ACL) reconstruction of patients with ACL tears. The 6 month results from the first 20 patients with combination Cytori Cell Therapy and bone-patellar tendon-bone (BPTB) grafts were presented at the Barcelona Knee Symposium on November 20, 2014.
Dr. Ramon Cugat, co-director of the Orthopedic Institute, Hospital Quiron Barcelona and the lead investigator of the study, performed autologous bone-patellar tendon-bone (BPTB) transplantation to replace damaged ACLs in 20 athletes who had sustained injury. Cytori Cell Therapy utilizing adipose derived regenerative cells (ADRCs(TM)) prepared by the Celution(R) System from a patient's own fat was used with the BPTB graft during the transplantation procedure. The cell preparation, injection into the graft and transplantation of the graft were all performed in the same surgical procedure.
"We are extremely encouraged by these results. I have treated thousands of patients with ACL repair and think that Cytori Cell Therapy may have additional benefits over current standard of care. We believe that use of ADRCs processed with Cytori's Celution System may translate into a more rapid recovery from a potentially career ending sports injury. We are hopeful that this could possibly lead to better quality grafts and improved graft strength," said Dr. Cugat.
Dr. Cugat discussed the preliminary six month outcomes at the meeting. The procedure was feasible and not associated with safety issues above that seen with a standard small volume liposuction. All patients recovered without any complications. The results were compared to a historical control group of patients who had the same surgical procedure by the same surgical team but without other interventions. Overall, recovery from pain and ability to return to the field appeared to be accelerated as a result of the ADRC enriched BPTB transplant The patient questionnaires and serial magnetic resonance imaging (MRI) scans of the knees following cell therapy were consistent with accelerated healing of the graft.
Dr. Cugat and his team are obtaining one year follow-up information on the treated patients and intend to report and publish these results in the future.
