Friday, October 31, 2014 11:47:51 AM
I've posted many of Dmitry Gabrilovich work on MDSC's and here is just one of them that ties it into Notch Signaling:
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Now... I think this is why our KOL's were chosen so carefully. Dmitry is the MD of MDSC's and actually coined the term MDSC's and he has spent his lifes work on researching Myeloid Derived Suppressor Cells and my last post where I seen David Carbone showing up at a "Notch .. conference" back in 2008 in Greece and Dmitry showing up at the world Notch Conference just this past summer... it just becomes clear that Peregrine can't just say Bavi and PS Targeting works, but more importantly why it works. By digging deeper and knowing more about Notch and why a drug works.... well, it looks like they can also start telling why a drug doesn't work and interesting this Roche drug = Erlotinib is said (by Peregrine KOL David Carbone that "dual targeting" may be needed. This seems to hopefully be setting up PS Targeting as that much needed and required target in order to improve Erlotinib and improve just about all over medicines. I think when this was found out way back when.... thats when the goal was not to work with one Big Pharma but get Bavi in the hands of many ( dozens of collaborations ..) and that way, its highly unlikely that one Big Pharma will pay off all other Big Pharmas lol or better yet, all we need is one Big Pharma to seize the opportunity and I believe that one Big Pharma is ready to piggy back along with PS Targeting and stay in business for another hundred years.
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Now, what is important ( in my opinion ) is that Big Pharma just may realize that allowing Bavi to be combined with everything and let current SOC keepers, maintain their SOC's eventually vs allowing Peregrine the (possible) opportunity to actually start dismissing drugs that do not work based on Notch Signaling events.
Time will tell.... but Notch Signaling is certainly on every ones radar and since PS Targeting reduces MDSC's and MDSC's are directly/indirectly related to Notch Signaling, how long will this take to play out before Peregrine reaches $100 per share? I do believe that Peregrine is playing nice because they could just start announcing all this now, but it seems to be playing out slowly for some Big Pharma reason.
Its just a matter of time
"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline." -- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!
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