CytoSorbents Corporation (CTSO)

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Effects of a novel cytokine haemoadsorbtion system on
inflammatory response in septic shock after cephalic
pancreatectomy – a case report
Dana Tomescu1,4
, Simona O. Dima2
, Sabina Tanasescu1
, Cristiana Pistol Tanase3
, Anca Nastase2
, Mihai Popescu4
1
Department of Anaesthesiology and Critical Care III, Fundeni Clinical Institute, Bucharest, Romania
2
Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania
3
“Titu Maiorescu” University, Faculty of Medicine, Bucharest, Romania
4
“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Abstract
Severe sepsis and septic shock are associated with an inflammatory cascade that is primarily responsible
for multiple organ dysfunction. To date, there are no specific treatments designed to modulate and rebalance
inflammatory cytokines levels. We present a case of a 50 years old man with postoperative septic shock
after undergoing cephalic pancreatectomy for a pancreatic cystic tumor. The use of a haemoadsorbtion
device (CytoSorb®) in combination with continuous veno-venous haemofiltration was associated with a
decrease in TNFa, IL-1ß and IFN? and an increase in IL-10 levels measured before and after two
consecutive procedures. The effect of CytoSorb® on inflammatory cytokines translated into a more stable
haemodynamic profile with a stable cardiac output and normalization of systemic vascular resistance index
and decreased vasopressor requirements. Further prospective large clinical trials are required in order to
determine the indications for CytoSorb® and to evaluate the overall outcome.
Keywords: sepsis, cytokines, CytoSorb, inflammation, haemodynamics, haemofiltration, pancreatectomy,
xMAP assay
Rom J Anaesth Int Care 2014; 21: 134-138
http://www.jurnalul-anestezie.ro/2014/2/11.pdf

http://www.jurnalul-anestezie.ro/2014/2/issue.html