Sunday, September 21, 2014 9:27:34 AM
By defining quantitative measures of intratumor cellular genetic and phenotypic heterogeneity in primary and met-astatic.... tumors and by assessing tumor topology, we determined that distant metastatic tumors are the most diverse, which can explain the frequent therapy resistance of advanced stage disease."
(IMHO, the phenomenon observed and discussed in this article is a concrete example demonstrating one of the primary reasons why multiple tumors should be injected with DCVAX-Direct, and why separate injections in distal tumors that are diverse in both genotype and phenotype is equivalent to creating a new vaccine in or as a result of each distal tumor injected.)
http://www.hubrecht.eu/research/vanoudenaarden/publications/CANCERRESEARCH2014.pdf
Respect Risk. Conduct Your Own Due Diligence. Manage your assets wisely. Diversify.
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