NorthWest Biotherapeutics Inc (NWBO)

[swamprabbit]

thank you for your kind and complimentary reply hodge. its true that I have spent a lot of time trying to make sense of this field. ive made two blunders already. the first was imuc and the second was oncy which crashed a few days ago. according to manish singh cars are limited to attacking a single antigen while most tumors are too heterogeneous with multiple antigens for car therapy to be effective. he also gives cancer vaccines a short shrift because he states that t cells on their own are simply not powerful enough. his approach is to find t cells within the cancer that are already successfully attacking the tumor,reengineering them outside the body to be more powerful, multiplying them into the billions and then reinfusing them. since these cells were already attacking the cancer to start with , the problem of multiple antigens is solved. this therapy has had what is considered jaw dropping success with stage 4 terminally ill metastatic melanoma patients in a stage 2 trial. 20 out of 90 were cured and remain so months or year later. the drawback is that apparently melanoma has much easier t cells to find and take out of the tumor than other cancers. the other drawback is the cytokine storm that follows treatment. no one knows how this will all work out. the combinations are endless.