Tuesday, September 02, 2014 11:10:09 PM
A combination of maraviroc and an anti-VEGF agent completely eliminated metastasis. In addition, depletion of IL6 in the TCM using an IL6 antibody also resulted in complete inhibition of metastasis.
These preclinical studies suggest that similar treatment might lead to new ways of preventing metastasis and treating metastatic patients. For example, IL6 receptor inhibitor tocilizumab is an FDA-approved anti-inflammatory drug and maraviroc or other CCR5 inhibitors could be administered prior or after surgery, possibly in combination with standard of care therapeutics.
http://www.bme.jhu.edu/news-events/news-highlights.php?id=455
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