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Maraviroc may prevent breast cancer from metastasizing, PRO140?

In the same report, the researchers say maraviroc, a drug already approved for treating HIV infection, blocked the siren call of CCL5 in tests on animals and cells and prevented tumor spread (metastasis). Additional experiments using a combination of maraviroc and a drug that blocks the VEGF protein suggest that the treatment duo could be an effective way to prevent metastatic disease in human breast cancer patients, according to the researchers.

Because the anti-retroviral drug maraviroc has already been approved by the U.S. Food and Drug Administration and has been shown safe for long term, oral use, it could be tested in clinical trials sooner rather than later, says Aleksander Popel, Ph.D., a professor in the Department of Biomedical Engineering at the Johns Hopkins University School of Medicine and member of the Johns Hopkins Kimmel Cancer Center.


Maraviroc is currently the only CCR5 antagonist on the market.

PRO 140, also a CCR5 antagonist, is close to being the 2nd CCR5 antagonist to reach the market as it completes its phase 2b substitution trial. PRO 140 is backed with $8 million in NIH grants and FDAs 'fast track' designation.

Might it serve both the HIV and breast cancer population?


http://medicalxpress.com/news/2014-09-prepped-tumor-cells-lymphatic-breast.html