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Re: Rkmatters post# 18134

Monday, 09/01/2014 12:43:10 PM

Monday, September 01, 2014 12:43:10 PM

Post# of 690557
Rk, the effects of chemorad plus glucocorticoids most likely immediately impair the lymphatic system. They just waited 6 weeks to check, it didn't actually take that long. However, criteria states:


"All tests and eligibility criteria must be completed within four weeks of completion of radiation and chemotherapy, following surgery."



Up to 4 weeks after SOC. And

Primary therapy must consist of surgical resection with the intent for a gross or near total resection of the contrast-enhancing tumor mass, followed by conventional external beam radiation therapy and concurrent Temodar chemotherapy. Patients having a biopsy only will be excluded. These primary treatments must be completed at least two weeks prior to first immunization.



Not "at most," but "at least," or "no sooner than."

Also:


Patients may have received steroid therapy as part of their primary treatment. Steroid treatment must be stopped at least 10 days prior to leukapheresis.



So, no sooner than 2 weeks after SOC, with glucocorticoid (steroid) use discontinued for at least 10 days (sometime after SOC), and yet no LONGER than 4 weeks after SOC. So, we have a window. I'm pretty convinced that the most significant lympholysis would show up in that window, and it would only marginally improve thereafter (assuming no DCVax or other immune boosting treatments given).
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