Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

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IL-1ß response causes Epithelial Breakdown

The first link published on August 29, 2014 is from UC Davis.

The report is about the Inflammatory response to HIV infection. This response causes gut inflammation by producing a cytokine called interleukin-1 beta (IL-1ß). IL-1ß breaks down intestinal lining and causes the establishment of a stable HIV reservoir in the gut.

IL-1ß was reducing the production of tight-junction proteins, which are crucial to making the intestinal barrier impermeable to pathogens. As a result, the normally cohesive barrier was breaking down.

This is the first report of Paneth cell sensing of SIV infection and IL-1ß production that links to gut epithelial damage during early viral invasion. In turn, the epithelial breakdown underscores that there’s more to the immune response than immune cells.

“The epithelium is more than a physical barrier,” said first author Lauren Hirao. “It’s providing support to immune cells in their defense against viruses and bacteria.”

http://www.ucdmc.ucdavis.edu/publish/news/newsroom/9205

The second link is to the Roskamp Institute web site.

There is a graph that shows the effects of increasing doses of Anatabine (RCP006 from Rock Creek Pharmaceuticals), a naturally occurring compound, on the release of an inflammatory molecule called interleukin 1-beta (IL-1ß).

http://www.rfdn.org/inflammaging.html

My thought

How many diseases could be prevented if the IL-1ß response to viral and bacterial assault is down regulated in the gut thus preventing the epithelial breakdown? I think I will keep taking my Anatabloc.