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Friday, 08/01/2014 11:44:37 AM

Friday, August 01, 2014 11:44:37 AM

Post# of 30990
The UK might be more receptive to Anatabine than the US.

Below is part of a report that appeared today.

http://medicalxpress.com/news/2014-08-anti-cholinergic-drugs-impair-physical-function.html

A new report reveals that anti-cholinergic drugs – which are used to treat conditions including asthma, high blood pressure, insomnia, dizziness and diarrhoea - could impact physical functions in elderly patients such as eating and getting dressed.
Up to half the UK's elderly population are prescribed at least one medication with anti-cholinergic properties. Other anti-cholinergic drugs are also sold over the counter without the need for a prescription.

These medications affect the brain by blocking a key neurotransmitter called acetylcholine. But they have been associated with side effects including dizziness, sedation, confusion, delirium, constipation and blurred vision

Previous studies have shown a link between these drugs and cognitive impairment, but this study is the first to summarise evidence of a physical decline among the elderly

The research team looked at 46 studies from around the world that included 60,944 patients who had taken anti-cholinergic medications for up to 10 years.

Lead researcher Dr Chris Fox, from UEA's Norwich Medical School, said. "We examined the effect of anti-cholinergic medication on physical function over a large time frame spanning decades of research.

"This is the first research to show a significant decline in physical, as well as cognitive, function. This means patients could become less and less able to carry out everyday activities like walking around, feeding themselves, washing and getting dressed.

"This is likely due to the direct effect on cholinergic neurons compounded by an increase in the blood-brain permeability.

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