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Alias Born | 10/03/2004 |
Thursday, July 31, 2014 7:37:18 PM
Nature | Outlook
Nanotechnology: Deliver on a promise
http://www.nature.com/nature/journal/v509/n7502_supp/full/509S58a.html
"Nanoparticles can carry a stronger payload than can antibodies, encasing thousands of drugs in a single molecule. Unfortunately, however, they can also accumulate in the liver and the spleen, where they provide no therapeutic benefit and can cause side effects. To minimize unwanted effects, researchers coat the particles with a layer of polyethylene glycol, which mimics water and effectively hides the drug from the liver cells that detect and engulf intruders. But minimizing liver uptake is still an important part of nanoparticle design, says Juliano."
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