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Re: leifsmith post# 95622

Tuesday, 07/29/2014 1:02:47 PM

Tuesday, July 29, 2014 1:02:47 PM

Post# of 146201
You can develop candidate compounds to use as ligands bound to the PEG shell for a virus without having the virus on hand,....

IF you have enough information about a target that the virus itself uses to try and gain access to its target cell.

For example - if it is known that a particular virus uses a protein or glycoprotein on a cell's surface as its binding target, and there is a 3D model of what that protein/glycoprotein looks like - then you can use that infomation to design potential mimics to that protein/glycoprotein to bind to the PEG component of a 'Cide.

BUT (and this is the ever famous big BUT) - in order to test those potential mimics out - you need to have access to the living virus, or at least a very effective model for it.

Initial design and concept are relatively easy if you have the right tools and expertise.

Validating and testing resulting drugs from those candidates is the tough part. And with something like Ebola (or for that matter MERS) that's going to have to be done in a Level 4 containment facility by extremely well trained and well equipped staff.

“The two most powerful warriors are patience and time.”
- Leo Nikolaevich Tolstoy

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