Amarin Corp Plc (AMRN)

[BioChica]

Certainly should increase the rate of events. Triglycerides and the number of sdLDL particles are linked. This paragraph includes eastern/western population risk factors, related to sdLDL.

Lipoproteins play a pivotal role in atherogenesis. Low
Density Lipoproteins-Cholesterol (LDL-C) is a major tar-
get in the guidelines for the prevention of CHD. However,
plasma LDL-C levels are insufficient to identify individu-
als with incidence of CHD events, because approximately
50% of all CHD events occur in persons with normal or
even low LDL-C concentrations [5]. LDL is composed of
heterogeneous particles differing in density, size and
chemical composition. It is reported that people with pre-
dominance of small, dense LDL (sdLDL) have a 3-fold
increased risk of CHD. Recently, sdLDL has been high-
lighted as a new potent risk marker for CHD in Westerners
and also in Japanese populations, which has relatively
lower LDL-C levels [6].