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Inflammatory Disorder of the Brain
New York—Activation of the immune system is the body’s natural reaction to infection or tissue damage, but when this protective response is prolonged or excessive, it can play a role in many chronic illnesses, not only of the body, but also of the brain.

“Psychiatric and neurodevelopmental disorders are being thought of more and more as systemic illnesses in which inflammation is involved,” noted Eric Hollander, MD, of Montefiore Medical Center and Albert Einstein College of Medicine, New York City. The cause of increased inflammation in these conditions isn’t always clear, but it has become a hot topic of investigation.
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Hollander, who spoke at the annual meeting of the American Psychiatric Association held here in May, was among several investigators who discussed how immune-inflammatory mechanisms can go awry and contribute to the development of depression, schizophrenia, and autism, insights that are leading to novel experimental approaches for these and other disorders.
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CYTOKINES IN DEPRESSION.
CYTOKINES IN DEPRESSION | ANTI-INFLAMMATORY TREATMENT IN SCHIZOPHRENIA | INFLAMMATORY MECHANISMS IN AUTISM

“The notion that inflammation plays a role in neuropsychiatric disorders really caught fire in the context of depression,” said Andrew Miller, MD, of Emory University School of Medicine, Atlanta.

This idea came from early studies showing that patients with depression, regardless of their physical health status, exhibited cardinal features of inflammation, including increases in inflammatory cytokines in the blood and cerebral spinal fluid. The inflammatory cytokines interleukin-6 and tumor necrosis factor (TNF), as well as the acute-phase reactant c-reactive protein (CRP), are the most reliable biomarkers of increased inflammation in patients with depression, said Miller.

Studies suggest that proinflammatory processes may be activated in people with autism spectrum disorders.

JAMA. Published online July 23, 2014. doi:10.1001/jama.2014.8276


Research on Psychiatric Disorders Targets Inflammation






Research on Psychiatric Disorders Targets Inflammation
News & Analysis (News) from JAMA — Research on Psychiatric Disorders Targets Inflammation
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