OncoSec Medical Inc (ONCSQ)

[$Moneypenny$]

Below is jbeam77 interpretation (he is currently banned from IHUB). I'd be really interested in Lasers' and/or DrBob99's take on this as well. See quote below:

"
This is my interpretation, it may be wrong. We know that Pd-1's negatively effect T cell responses. We want T cell responses, as it is our immune system doing its thing. Many tumor types express Pd-1 (there's a complex interaction that occurs between ligands) which then inhibits the T cells from doing their job. Anti Pd-1's are drugs that inhibit Pd-1/Pd ligand interaction, thus boosting our immune system and allowing the T cells to respond and not being killed off by the tumor.

Based on the statistics, only 20-40% of people respond to these anti Pd-1's and for some reason, many fail to respond. From my understanding, IL2 + electroporation induces IFN gamma, which in turn supports the T cell response to fight the tumor. I think there is a misconception that IL2 will flip a switch that will make people respond immediately respond. What I think is happening is that the the IL2 stimulates the immune system to the point that it overwhelms the tumor, which is being inhibited by the Anti Pd-1 drug. Thus making "non responders" a "responder" through immunogenic enhancement (IL2) while inhibiting the rumors ability to kill T cell (anti Pd-1 drug).

What's going on with the expansion study is the investigation to what extent can ONCS use IL2 to enhance a T cell response through ifn-gamma. How much can we stimulate the immune system while decreasing the effects of Pd-1? Each person will be different and some may need high levels of IL2 to overcome the tumors inhibited Pd-1 response. ONCS needs to find out how much IL2 they can safely administer while still obtaining peak immune performance.

So the answer to you question... IMO, that statement says the IL2+ electroporation creates the systematic response that we need. It does it at the tumor site and throughout the body. The hope is that they can create such an overwhelming immune response that tumors which were previously resistant, will then be overwhelmed by the immune system while subsequently being inhibited in the Pd-1 response.

Check out this article, this shit has been around a while and the data supports ONCS's hypothesis.

http://www.jimmunol.org/content/186/5/2772.full


Feel free to post on the forum, it may be helpful for some to understand the science. This is just my interpretation though, but it appears to be supported by other researchers, other than ONCS. Please excuse any typos, typing on an Ipad sucks,"