Avid Bioservices Inc (CDMO)

[biopharm]

Think Big.. Think Bavi...yet again...

So here we go again, PS Targeting! ....yet what I have failed to see anywhere is the possibility for helping Osteoporosis. Now, if our bones are growing stronger as we age, with less stressed cells within, especially when they break... that means less stressed cells...because stressed cells flowing through the body don't seem logical to me....


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Strong Bones for Healthy Aging:

Your bones are alive

They may feel like rocks, but bones are living things. In fact, a group of cells (called osteoblasts) are constantly churning out new bone, while a second set (called osteoclasts) destroys bone by gobbling it up like Pac-Man.

This constant tug of war between creation and destruction is called bone remodeling.

It’s the reason bones regenerate after a break, grow rapidly during youth, and, unfortunately, decline later in life when the balance tips toward destruction.
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http://www.health.com/health/gallery/0,,20471612_2,00.html


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Role of Phosphatidyl-Serine in Bone Repair and Its
Technological Exploitation

Molecules 2009, 14, 5367-5381; doi:10.3390/molecules14125367
molecules
ISSN 1420-3049
www.mdpi.com/journal/molecules

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As any other tissue of the vertebrate and human body, bone is a living tissue that undergoes a continuous remodelling process where the older bone is continuously resorbed by the activity of some cells, the so called “osteoclasts”, and gradually replaced by newly-formed tissue deposited by bone producing cells. “Bone turn-over” is the term which defines this continuous cycle of bone resorption and apposition which is driven by these types of cells. Bone turn-over is finely tuned by biochemical signaling (hormonal, autocrine and paracrine) and is the result of a complex series of biochemical and cellular interactions. These events contradict the apparently inert nature of the bony tissue. Indeed, the
annual rate of bone turn-over in a healthy individual ranges from 10% to 20% percent of the whole skeleton [1].

Alongside the biochemical signaling, bone is deposited in proportion to the compressive cyclic load that the tissue has to sustain. A microscopic analysis shows that bone deposition follows the lines of mechanical stress. Therefore, each bone segment constantly adapts its inner structure to the applied loads, a process termed “Bone Remodelling” [1,4–6]; this phenomenon can be easily seen at work also during the fracture healing process [7–9] or during bone regeneration by limb lengthening techniques
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http://webcache.googleusercontent.com/search?q=cache:BPO4lXx3mTkJ:www.mdpi.com/1420-3049/14/12/5367/pdf+&cd=5&hl=en&ct=clnk&gl=us


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Now I wonder if these guys had some PS Targeting way back when...

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June 2007

Breaking Point:

L. Joseph Melton III and B. Lawrence Riggs changed the world's thinking about bone disease and aging.
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When Melton and Riggs started working together, osteoporosis wasn’t even considered a disease, says Riggs’ protégé, Sundeep Khosla, M.D., who took over as director of osteoporosis research at Mayo when Riggs retired in 2003 and has since become chair of the endocrine research unit. “You got older, you got hunched over, and you broke bones. That was just what happened with aging,” he says.

In order to learn more about whether osteoporosis was a natural consequence of aging and its collective cost to society, Riggs and Melton accessed a research gold mine—a warehouse of patient data reaching back to the early 20th century, when Mayo Clinic first began keeping comprehensive patient records. The first results of their collaboration were published in the summer of 1980 in the journal Clinical Orthopaedics and Related Research: “Epidemiology of Fractures of the Proximal Femur in Rochester, Minnesota” and “The National Cost of Acute Care of Hip Fractures Associated with Osteoporosis.” Looking at a 10-year period, Riggs, Melton, and two other Mayo colleagues found that the rate of hip fracture doubled with each decade of life after the age of 50. Projecting their figures nationwide, the Mayo team estimated that osteoporosis led directly to some 150,000 hip fractures in the United States each year. Their estimate of the direct annual cost of treating those patients: roughly $1 billion.
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http://www.minnesotamedicine.com/Past-Issues/Past-Issues-2007/June-2007/Feature-June-2007

Currently...Lawrence Riggs at Mayo

http://www.mayo.edu/research/faculty/riggs-b-lawrence-jr-m-d/bio-00025845

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Now my question is ... just as not taking care of your teeth > causes gum disease as you lose bone and can cause other problems.. everyone following? Well the same can be said with your bones overall, later in life.

CALICO... you listening? wouldn't this play into that little anti-aging theme you have going on over there?

Of course, with the new understanding of PS, I'm sure all views need to be revised to include PS targeting in mostly all treatment. No wonder why Peregrine can be very selective on a Big Pharma partner... time to wipe the slates clean and bring on Bavi!

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Broken bones can lead to fat embolism syndrome

DEAR MAYO CLINIC: If you have a broken bone, can bone marrow leak into your system? If so, how does it affect the rest of your body?

ANSWER: When you break a bone, fat tissue from the bone marrow can leak into your blood. In many cases, this doesn't cause any problems. But in some situations, it may lead to a disorder known as fat embolism syndrome (FES). Although uncommon, FES can result in serious complications such as severe lung problems and seizures.

http://articles.sun-sentinel.com/2011-06-13/health/fl-jjps-bones-0615-20110613_1_bone-marrow-smaller-bones-fat-cells

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Enjoy the weekend all...sooner or later, the plan will be revealed for all.