Thursday, April 24, 2014 5:48:35 PM
http://www.sbir.gov/sbirsearch/detail/116872
http://www.biocentury.com/companies/cancer_therapeutics_laboratories_inc
http://sbirsource.com/sbir/firms/15515-cancer-therapeutics-laboratories-inc
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published July 2010
http://www.jimmunol.org/content/early/2010/07/19/jimmunol.1000901.full.pdf
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Oct 15, 2014
At the present time, Dr. Epstein is investigating the role of human suppressor cell populations such as T-regulatory cells (Treg) and myeloid derived suppressor cells (MDSC) on tumor growth and immune escape. Antibodies directed against these cells are being generated and conjugated to co-stimulatory molecules or siRNA reagents capable of silencing key genes associated with suppressor cell function. The major direction of the laboratory is to develop novel methods of treating suppressor cells to enable tumor and dendritic cell vaccines to provide an effective and lasting immune response to tumors. As in vivo models, several syngeneic murine tumor models are being used to test the effectiveness of these approaches before specific reagents are translated to man.
http://www.lungcancerfoundation.org/2013/10/o-c-t-1-5-a-l-a-n-l-e-p-s-t-e-i-n-m-d-p-h-d/
"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline." -- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!
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