Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

"Aging Process Speeded By Chronic Inflammation" from Liberty Voice by Beth Balen:

Excerpts:
"Healthspan: the years of life spent relatively free of disability and serious illness. A study from the Yale School of Medicine released in the October, 2013, issue of Cell Metabolism shows that chronic inflammation can speed the aging process and significantly reduce healthspan.

Chronic inflammation is different from the swelling that occurs with a specific injury, such as a sprained ankle. Acute inflammation can typically be resolved with ice and time. Chronic inflammation is a slowly advancing disturbance that cannot be felt or tested for.

It starts with the immune system, the body’s first line of defense against damage or harm. During the aging process the body’s cells change, causing the immune system to produce low-level, chronic inflammation throughout the body. The Yale research is the first to show that inflammation is directly linked to functional deterioration during aging.

The Yale study has identified an immune sensor, Nlrp3, as the specific trigger of inflammation. Nlrp3 is activated with age and is the common start of inflammation-driven functional decline. This inflammation is associated with many chronic age-related diseases, including gout, arthritis, diabetes, impaired memory, and Alzheimer’s disease.
If the Nlrp3 immune sensor could be manipulated to reduce or delay the chronic inflammation that speeds the aging process, it could possibly lead to prolonged healthspan, and old age reasonably free of disability or disease.

A study published in the Canadian Medical Association Journal in November, 2013, also said that chronic inflammation is associated with an array of unhealthy aging characteristics, and a likelihood of successful aging that is decreased.

Aging

And a study from the Karolinska Institute in Sweden, published in the journal Alzheimer’s & Dementia, shows that Alzheimer’s disease is also associated with inflammation. The problem with Alzheimer’s is that there are not enough of the molecules needed for tissue recovery, so the resolution of the inflammatory process does not happen. The study determined that stimulating the resolution of inflammation may result in less loss of brain function."

"As the population over 50 increases, doctors are seeing an associated increase in age-related diseases. Researchers now say treating those individual diseases may be wrong, and that they may be more effectively handled by treating the chronic inflammation shown to speed the aging process."

Article at:
http://guardianlv.com/2014/03/aging-process-speeded-by-chronic-inflammation/