Avid Bioservices Inc (CDMO)

[biopharm]

I just realized my post never updated to include that text! thanks CP! Now, Dmitry Gabrilovich made such a clear statement on the understanding of immunesuppression and there are many publications that admit there was no understanding .... till now. Here are just two of the many... one from 1996 and one from 2008

1996

Mechanisms of tumor-induced immunosuppression: evidence for contact-dependent T cell suppression by monocytes.

The factors involved in this suppression are not completely understood.

2008

Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells.

Abstract

Emerging evidence indicates that the Achilles' heel of cancer immunotherapies is often the complex interplay of tumor-derived factors and deviant host properties, which involve a wide range of immune elements in the lymphoid and myeloid compartments. Regulatory lymphocytes, tumor-conditioned myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages, and dysfunctional and immature dendritic cells take part in a complex immunoregulatory network. Despite the fact that some mechanisms governing tumor-induced immune tolerance and suppression are starting to be better understood and their complexity dissected, little is known about the diachronic picture of immune tolerance. Based on observations of MDSCs, we present a time-structured and topologically consistent idea of tumor-dependent tolerance progression in tumor-bearing hosts.

http://www.ncbi.nlm.nih.gov/pubmed/18364001

Here is the "preface" of the recently updated 2014 2nd edition that includes Peregrine KOL Dmitry Gabrilovich as one of the two editors--- along with Arthur A. Hurwitz:

Interesting read/introduction.

Tumor Induced Immune Suppression

Mechanisms and Therapeutic Reversal

http://download.springer.com/static/pdf/69/bfm%253A978-1-4899-8056-4%252F1.pdf?auth66=1398375899_ce475e8477479f84db7b99c48eef058a&ext=.pdf


now when you look forward to reading the "index" from this book, you know you are a Bavi addict. : )

http://www.amazon.com/Tumor-Induced-Immune-Suppression-Mechanisms-Therapeutic/dp/1489980555