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DewDiligence

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DewDiligence

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Monday, 10/27/2008 10:53:23 AM

Monday, October 27, 2008 10:53:23 AM

Post# of 19309
Catalyst Biosciences Selects Drug Candidate in FVIIa Program for Hemophilia

[This PR is from May 2008 but I hadn’t seen it until now.]

http://www.reuters.com/article/pressRelease/idUS127338+06-May-2008+PRN20080506

›May 6, 2008

SOUTH SAN FRANCISCO, Calif./PRNewswire/ -- Catalyst Biosciences, Inc., a pioneer in the discovery and development of engineered proteases known as Alterase™ therapeutics, announced that it has selected CB 813, an improved, second-generation variant of human coagulation factor VIIa, as a development candidate for the treatment of acute bleeding in hemophilia patients.

CB 813 was created using Catalyst's proprietary therapeutic protease platform technologies and know-how. CB 813 is designed to substantially enhance clot-generating activity at the site of bleeding and therefore achieve clinical efficacy with fewer and lower doses than current therapy. In established hemophilia models of acute bleeding, CB 813 has demonstrated a significant improvement in potency compared with the marketed recombinant factor VIIa product, NovoSeven and a competing, second-generation product, NN1731.

Catalyst intends to file an Investigational New Drug (IND) application for CB 813 and commence human clinical studies in hemophilia patients in 2009.

"Patients receiving factor VIIa therapy typically require multiple doses of drug and extended treatment times to manage acute bleeding episodes," said Gilbert C. White, II, M.D., Executive Vice President for Research and Director, Blood Research Institute, Blood Center of Wisconsin. "I am excited by the potential shown by CB 813 to improve the efficiency of treatment by achieving a faster onset and an extended duration of therapeutic benefit to patients. These advantages may significantly reduce both the number of doses and treatment time required to manage bleeding and restore normal hemostasis."

"The selection of this development candidate is an exciting milestone for Catalyst. Created to more rapidly and effectively stop bleeding, CB 813 holds great promise as a new agent in the treatment of hemophilia," said Nassim Usman, Ph.D., Chief Executive Officer of Catalyst Biosciences. "CB 813 is representative of a new class of improved variants of factor VIIa discovered using Catalyst's proprietary protease engineering platform and know-how. Created within 12 months from program start up, CB 813 and related compounds demonstrate the power of our platform."

About Catalyst Biosciences

Catalyst Biosciences is developing the next generation of biopharmaceuticals by harnessing the catalytic power of engineered proteases to target proteins underlying disease. Catalyst's discovery platform rapidly creates and optimizes tailor-made protease drug candidates, called Alterase™ therapeutics, that are applicable across a broad spectrum of disease categories. Initially, Catalyst is focusing its product development efforts on Alterase drug candidates for hemophilia, age-related macular degeneration, oncology and inflammation. To date, Catalyst has established two discovery research and product development agreements with Wyeth Pharmaceuticals and Centocor [JNJ] Research & Development, Inc.

Catalyst is privately-held with backing by leading venture firms including Burrill & Company, HealthCare Ventures, Johnson & Johnson Development Corporation, Morgenthaler Ventures, Novartis BioVentures, RCT BioVentures and Sofinnova Ventures. For more information, please visit www.catbio.com.‹

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