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RespireRx Pharmaceuticals Inc. (RSPI)

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Last Post: 7/27/2016 6:02:40 PM - Followers: 177 - Board type: Free - Posts Today: 10

RespireRx Pharmaceuticals (formerly Cortex), is a biopharmaceutical company focused on the discovery and development of novel therapies for the treatment of Sleep Apnea, drug-induced Respiratory Depression, and other brain mediated breathing disorders.  In August 2012, Cortex merged with privately held Pier Pharmaceuticals in an all stock transaction, with Pier becoming a wholly-owned subsidiary of Cortex -

RespireRx website -

Clinical Trials -

--- Dronabinol - Phase 2b in Obstructive Sleep Apnea, data due Q3-16

--- CX-1739 - Phase 2a in Opioid Induced Respiratory Depression, planned to start 2016

--- CX-1739 - Phase 2a in Central Sleep Apnea, planned to start in 2016

--- CX-1739 / CX-717 - Phase 2a in Spinal Damage, Pompe Disease, pending funding

--- CX-717 - Combination formulation with Opioids to reduce Respiratory Depression

Preclinical -

--- CX-1942 -
Injectible water soluble prodrug of CX-1763 for intravenous use, targeting Respiratory Depression, approx 5 times more potent than CX-717 in animal models of RD. Preclinical

--- Dronabinol - Extended Release Formulation planned


Summary of Clinical Programs -


Dronabinol -  Targeting Obstructive Sleep Apnea.  

--- Ongoing Phase 2b in Obstructive Sleep Apnea, 120 subjects, dosing 2.5 mg and 10 mg qd for 6 weeks, placebo controlled, topline data due Q3-16, fully funded $5 mil from the NIH

This program was acquired in the Pier Pharma merger.

Phase 2b enrollment began Dec 2012, with full funding from the NIH (approx $5 mil in NIH funding).  The trial will enroll 120 patients, using two doses of Dronabinol -- a 2.5 mg arm dosing for 6 weeks and a 10 mg arm dosing for 4 weeks after a 2 week dose escalation.  These are similar dosing levels to those that Dronabinol already has FDA approval for in CINV and AIDS anorexia.  Patients will receive Dronabinol 1 hour prior to bedtime. Estimated completion date is May 2015  

Dr. Carley (Professor at the Univ of Illinois, and former Chief Science Officer at Pier Pharma) is the principal investigator. Enrollment began Dec 2012 at the Univ of Illinois, and Northwestern Univ will also be participating.  A total of 4 major centers involved in the study.

Dronabinol is a synthetic derivative of the naturally occurring substance in the cannabis plant, namely delta-9-tetrahydrocannabinol, otherwise known as delta-9 THC. Dronabinol is one of many derivatives found in the cannabis plant which includes other compounds as well such as cannabidiol (CBD) and cannabichromene (CBC), to name a few.

Dronabinol is currently FDA approved for use in refractory chemotherapy-induced nausea and vomiting (CINV) as well as for anorexia associated with weight loss in patients with AIDS.  Its use in these two indications is at a dose range of 2.5 mg to 10 mg twices daily.    Cortex acquired the Dronabinol program in its merger with Pier Pharma in Aug 2012, and Dronabinol is being evaluated to see whether a low dose Dronabinol therapy used in a proprietary formulation given daily at bedtime will significantly improve the apnea-hypopnea index (AHI) as well as other subjective and objective measures of clinical improvement in patients with OSA.

Dronabinol is an orally active cannabinoid which, like other cannabinoids, has complex effects on the central nervous system (CNS), including central sympathomimetic activity. Cannabinoid receptors have been discovered in neural tissues. These receptors may play a role in mediating the effects of dronabinol and other cannabinoids.
The mechanism of action of dronabinol's benefit in OSA is thought to be complex but related to the following dynamics outlined below and in the graphic representation that follows:
  • Peripheral CB1 receptor activation directly inhibits the afferent vagus nerve, and indirectly closes 5-HT3 ion channels (peripheral 5-HT induces apnea, via 5-HT3 receptors), leading to a reduced negative feedback loop on upper airway motor (UAM) tone and activity
    In the CNS, decreased serotonin (central 5-HT excitatory to motor neurons and prevents apnea) and noradrenaline levels during sleep ↓upper airway motor outputs.
    Central CB1 receptor activation results in an ↑ in brainstem monoamine levels, including serotonin (5-HT) and noradrenaline (NA), leading to ↑ upper airway muscle tone & activity.

Dronabinol Phase 2a results in Obstructive Sleep Apnea -

(This data was presented at the May 2011 meeting of the American Thoracic Society) -

The Phase 2a enrolled 22 patients, dosed for 21 days, with doses escalating from 2.5 mg to 5 mg to 10 mg.  A single dose was given 30 minutes before bedtime.   Statistical improvement in the primary endpoint (AHI -- Apnea-Hypopnea Index) was seen at the 2.5 and 10 mg dose levels, with a reduction in the AHI index score in the moderate-severe sleep apnea patients of approx 30%.  Dronabinol was safe and well-tolerated, with no degradation of sleep architecture. 


AMPAKINES - Allosteric upmodulators of the AMPA receptor

--- CX-1739 - Phase 2a in Opioid Induce Respiratory Depression, planned to start 2016

--- CX-1739 - Phase 2a in Central Sleep Apnea, planned to start in 2016

Ampakines are allosteric, meaning they amplify existing neural signals, rather than creating brand new neural signals as an agonist compound does.  Low Impact type Ampakines upregulate AMPA activity without producing significant BDNF upregulation, while High Impact Ampakines also upregulate production of BDNF and other neural growth factors.   Low and High Impacts bind at different binding sites on the AMPA receptor.  Low impacts are inherently much less prone to inducing excitotoxicity/seizures than high impacts.   In fact, low impacts like CX-717 and CX-1739 are so safe that it wasn't really possible to generate a true MTD - Max Tolerated Dose in Phase 1.         

 Low Impact Ampakines -

CX-1739 - Approx 3 times more potent than CX-717, halflife 7.2 hours, patent to 2028

Phase 2a completed in Sleep Apnea, with extremely strong results seen in Central type Sleep Apnea, and good activity also seen in Mixed type Sleep Apnea.   CX-1739 can also target ADHD, the cognitive aspects of Schizophrenia, Depression, and all other indications suitable for a low impact Ampakine (ie - where BDNF upregulation isn't a requirement).  CX-1739 is completely free from the preclinical 'artifact' histological phenomenon  that derailed development of CX-717 - 

Sleep Apnea Phase 2a results (CX-1739) -


CX-1942 - Water soluble prodrug of CX-1763 for intravenous use, targeting Respiratory Depression, approx 5 times more potent than CX-717 in animal models of RD. Preclinical

CX-1763 - Low impact compound, preclinical, the oral version of CX-1942

CX-2076 - Low impact compound, preclinical

CX-717 -

Phase 2a completed in Respiratory Depression in which CX-717 demonstrated Ampakine's ability to both prevent and reverse opioid induced Respiratory Depression without diminishing the pain relieving properties of the opioid.   Ampakines have also demonstrated preclinically the ability to reverse barbiturate induced Respiratory Depression, as well as Propofol (and benzodiazepines), clinical areas without current treatments (naloxone/Narcan does not work on barbiturates).   CX-717 also completed a Phase 2a  in ADHD  and showed statistically significant efficacy in both primary endpoints - the hyperactivity and the inattentiveness subscales.  Unlike current stimulant type ADHD drugs, Ampakines do not increase heart rate or blood pressure.  CX-717 also showed good efficacy in reversing the cognitive effects of Sleep Deprivation (UK study) -

Respiratory Depression Phase 2a results (CX-717) -

ADHD Phase 2a results (CX-717) -

Sleep Deprivation Phase 2a results (CX-717) (UK study) -


High Impact Ampakines - (upregulate BDNF)
With the ability to upregulate BDNF and other brain growth factors, high impact Ampakines may have the potential to slow, halt, or even reverse many neurodegenerative diseases.    Cortex's high impacts (Benzamide related) are different chemical families than the high impacts of other companies like Lilly, Glaxo, and Merck (Biarylpropylsulfonamides, Benzothiazides, etc).  In the 2008-2010 period, Cortex also developed and patented multiple new families of improved high impacts which are awaiting funding/partnership.     

CX-1632 - (S-47445) - Phase 1 completed, targeting Alzheimer's (Servier)

CX-1846 - Lead in-house high impact, awaiting IND enabling studies, possibly targeting Parkinson's

CX-1837 - High impact 


Key Press Releases -


July 1, 2014 - Cortex enters into a new licensing agreement with Univ of Illinois for use of cannabinoids in the treatment of Sleep Related Breathing Disorders -

Aug 14, 2012 - Cortex announces merger with Pier Pharmaceuticals in an all stock transaction -

Oct 6, 2011 -- Servier Exercises Option to Cortex's Ampakine CX1632, an Innovative Compound in Clinical Development for Alzheimer's Disease  --

Aug 24, 2011 -- Cortex Receives U.S. Patent for the use of Ampakine Molecules to Treat Respiratory Depression --

Apr 26, 2011 -- Cortex Receives Granted US Patent for its Lead AMPAKINE® Molecule CX-1739

Mar 16, 2011 -- Cortex Reacquires all Ampakine Compounds, Related Patents and Exclusive Global Rights for Respiratory Depression from Biovail  --

Feb 2, 2011 -- CX-1739 Improves Respiratory Parameters In Obstructive Sleep Apnea Patients --

Jul 6, 2010 - Funding from The Michael J. Fox Foundation to discover drug candidates for Parkinson's disease --

Aug, 2008 - Cortex's AMPAKINE Molecule CX717 Has Positive Effects in Opiate-Induced Respiratory Depression in a Phase IIa Clinical Study -

Q1-2006 - ADHD Phase 2a results (CX-717) -


Ampakines have the potential to address indications that range from orphan indications to $1 Billion plus sized markets -

Respiratory -

Opioid Induced Respiratory Depression -

--- Positive Phase 2a data with CX-717

--- Phase 2a with CX-1739 planned to start 2016

Barbiturate, Propofol, Benzodiazapine Induced Respiratory Depression

Sleep Apnea ---- (positive Phase 2a data with CX-1739)

--- Phase 2a with CX-1739 in Central Sleep Apnea planned to start in 2016

Respiratory aspects of -

Pompe Disease,
Spinal Cord Damage,
Perinatal Respiratory Distress
Heart Failure Patients 
Sickle Cell Crisis

Neuro / Psych -

Low Impact Ampakines -
ADHD -------------------------------------------------------(positive Phase 2a data with CX-717)

Cognitive aspects of Alzheimer's Disease
Cognitive aspects of Schizophrenia
Cognitive aspects of Parkinson's
Cognitive aspects of Sleep Deprivation ----------(positive Phase 2a data with CX-717 - UK study)
MCI (Mild Cognitive Impairment)
Memory Loss due to ECT (Electroconvulsive therapy)
Memory Loss due to CABGS (Coronary Artery Bypass Graft Surgery)
EDS (Excessive Daytime Sleepiness)

High Impact Ampakines - (disease modifying via BDNF upregulation)
Alzheimers Disease
Parkinson's Disease
Huntington's Disease
ALS (Amyotrophic Lateral Sclerosis)
Rett's Syndrome
Angelman Syndrome
Fragile X
SCI (Spinal Cord Injury)
TBI (Traumatic Brain Injury)


RespireRx company website:

Dr. Tracy (NI Research / NeuroPerspective) Cortex commentary:

Patent database : Ampa related patents -

Information website for Ampakines (not an official Cortex company website):

Research Paper abstracts for "Ampakines":

Yahoo Cortex Message Board:

Silicon Investor Cortex Message Board:

SEC Filings -

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Current Price
Bid Ask Day's Range
RSPI News: Statement of Changes in Beneficial Ownership (4) 07/19/2016 05:53:12 PM
RSPI News: Current Report Filing (8-k) 07/13/2016 08:34:11 AM
RSPI News: RespireRx Pharmaceuticals Inc. to Present at the Cantor Fitzgerald 2nd Annual Healthcare Conference on July 13, 2016 07/12/2016 10:42:00 PM
RSPI News: Proxy Statement (definitive) (def 14a) 07/08/2016 11:40:52 AM
RSPI News: Statement of Changes in Beneficial Ownership (4) 06/20/2016 07:55:00 PM
#39605   TheSaint, I think they probably have something gfp927z 07/27/16 06:02:40 PM
#39604   gfp...well stated about the diversification and patience. TheSaint09 07/27/16 05:17:54 PM
#39603   A+C, >> choice as a lotto << gfp927z 07/27/16 03:19:31 PM
#39602   Thank you. With that said, I find ARBITRARY & CAPRICIOUS 07/27/16 02:24:09 PM
#39601   A+C, The company needs to issue some gfp927z 07/27/16 02:06:20 PM
#39600   I have never directed a post to you ARBITRARY & CAPRICIOUS 07/27/16 02:01:26 PM
#39599   The same could be said about your self control. Joey Rosa 07/27/16 01:59:38 PM
#39598   $2K of stock traded....absolutely pathetic with results pending... ARBITRARY & CAPRICIOUS 07/27/16 01:40:31 PM
#39597   I took a small position yesterday of about dave86 07/27/16 10:29:59 AM
#39596   So with results likely anytime between now and ARBITRARY & CAPRICIOUS 07/27/16 10:05:28 AM
#39595   Concerning the CX-1739 RD trial, one aspect to gfp927z 07/25/16 01:32:00 AM
#39594   CX-1739 Phase 2. Final Data Collection May 2016. drfreely 07/24/16 10:14:12 AM
#39593   Does anyone know when are we expecting phase ggupta1767 07/24/16 09:28:33 AM
#39592   Some interesting posts about RSPI by 'BioHunter' over gfp927z 07/23/16 02:16:41 PM
#39591   I don't necessarily disagree. I am interested TheSaint09 07/23/16 11:17:36 AM
#39590   No, you shouldn't be in this stock! corwatcher 07/23/16 02:53:06 AM
#39589   After reading the referenced s.e.c. filing for which drfreely 07/21/16 03:47:02 PM
#39588   ?? Thumbs up my friend. Don't sell yourself short. food4thought 07/21/16 12:12:39 PM
#39587   regardless of the timing of a R/S, wouldn't ARBITRARY & CAPRICIOUS 07/21/16 12:07:19 PM
#39586   I'd be interested in comments about the information Dogleg9 07/21/16 09:45:12 AM
#39585   Food4, I haven't followed RSPI that closely gfp927z 07/21/16 08:09:44 AM
#39584   If you need to know anything about this food4thought 07/21/16 12:40:47 AM
#39583   A+C, Yes, most likely between now and gfp927z 07/20/16 08:54:25 PM
#39582 we can get a surprise at any time.... ARBITRARY & CAPRICIOUS 07/20/16 08:10:53 PM
#39581   A+C, >> time frame for next results << gfp927z 07/20/16 08:06:39 PM
#39580   what presentations? ARBITRARY & CAPRICIOUS 07/20/16 03:42:57 PM
#39579   If you can read or listen to presentations Joey Rosa 07/20/16 03:37:18 PM
#39578   exciting time yet no one can provide a ARBITRARY & CAPRICIOUS 07/20/16 03:35:29 PM
#39577   Please excuse the typos Joey Rosa 07/20/16 02:57:14 PM
#39576   It is definitely an exiting time. I have Joey Rosa 07/20/16 02:55:39 PM
#39575   Think AC sounds like a teenager. Maybe one drfreely 07/20/16 02:50:20 PM
#39574   I just found this one, and I'm trying senderos 07/20/16 01:08:03 PM
#39573   We generally don't have any hostility in this Joey Rosa 07/20/16 10:53:51 AM
#39572   he has gotten asked many times from underwater ARBITRARY & CAPRICIOUS 07/19/16 07:35:25 PM
#39571   Nope. When is it? rand0m 07/19/16 07:21:01 PM
#39570   Did chaff respond to that ???? ARBITRARY & CAPRICIOUS 07/19/16 07:19:43 PM
#39569   when is phase 2 data released? rand0m 07/19/16 01:39:39 PM
#39568   We have seen people like you come and Joey Rosa 07/19/16 01:39:29 PM
#39567   Appreciated A&C ARBITRARY & CAPRICIOUS 07/18/16 10:46:13 PM
#39566   A+C, Company guidance for the release of gfp927z 07/18/16 10:43:09 PM
#39565   You sure post here a lot for someone TheSaint09 07/18/16 09:31:19 PM
#39564   cant check respirex website for timeline as it ARBITRARY & CAPRICIOUS 07/18/16 07:27:59 PM
#39563   timeline for results...not even that...jusdt says buy and ARBITRARY & CAPRICIOUS 07/18/16 07:20:03 PM
#39562   i speak for thousands who are lost ..they ARBITRARY & CAPRICIOUS 07/18/16 07:18:14 PM
#39561   everyone now underwater here expect the front loader ARBITRARY & CAPRICIOUS 07/18/16 07:16:54 PM
#39560   many have asked for cuirrent thoughts on the ARBITRARY & CAPRICIOUS 07/18/16 07:15:33 PM
#39559   twiztedtriple6 07/18/16 06:47:52 PM
#39557   CX-1739 - any time line for those results....thanks ARBITRARY & CAPRICIOUS 07/18/16 04:21:52 PM
#39556   Oops many underwater already......... ARBITRARY & CAPRICIOUS 07/18/16 04:14:11 PM
#39555   What happened....another long term baggies for the naive........ ARBITRARY & CAPRICIOUS 07/18/16 03:49:34 PM