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Sunshine Biopharma Inc. (SBFM)

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"The Future Of Medicine"
 

 




 
Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 





 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 
 


Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697




 



Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.


Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options




 





 

 



 

 
 
Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.







Check out SBFM's drug Adva-27a (27a) vs the leading chem drug Etoposide (2) - results are better in every category except two. And in the multi drug resistance breast cancer category (MCF7R) it's over 3x more effective. 







 
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).




The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.
 






Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug







 



http://sunshinebiopharma.com/investor/press-releases/
 
November 19, 2014
 
 
SUNSHINE BIOPHARMA SIGNS AGREEMENT WITH LONZA TO MANUFACTURE ITS LEAD ANTI-CANCER COMPOUND, Adva-27a
 
 
Montreal, Quebec, Canada -- (Marketwire) -- Sunshine Biopharma Inc. (OTCQB: “SBFM”), a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, announced today an agreement with Lonza, a leading development and manufacturing company, for the manufacture of its anti-cancer drug, Adva-27a.  Lonza’s expertise and experience in small molecule development and manufacturing of active pharmaceutical ingredients, was an ideal fit for Sunshine’s Adva-27a.  Lonza’s manufacturing capacity ranges from gram quantities for process validation to kilogram amounts for clinical trials and ton quantities for commercialization.  Manufacturing will begin at Lonza’s Nansha, China facility with the remaining key steps to be conducted in Lonza’s high containment cytotoxic facility in Visp, Switzerland.
 
“We are delighted to have a global leader like Lonza as our manufacturing partner,” said Dr. Steve N. Slilaty, President and CEO of Sunshine Biopharma.  “We have made significant recent strides in terms of research results showing the effectiveness of our lead compound against cancer cells as well as in our manufacturing and recent fund raising efforts.”
 
“We are very excited to be working with Sunshine Biopharma on the development of their promising anti-cancer compound”, said James Leresche, Ph.D., Head of Lonza’s Chemical Development Services. “This development project is an example of Lonza’s support and commitment to emerging companies with innovative and potentially life-saving treatments like Adva-27a.”
 
About Lonza
 
Lonza is one of the world’s leading and most-trusted suppliers to the pharmaceutical, biotech and specialty ingredients markets. We harness science and technology to create products that support safer and healthier living and that enhance the overall quality of life.
 
Not only are we a custom manufacturer and developer, Lonza also offers services and products ranging from active pharmaceutical ingredients and stem-cell therapies to drinking water sanitizers, from the vitamin B compounds and organic personal care ingredients to agricultural products, and from industrial preservatives to microbial control solutions that combat dangerous viruses, bacteria and other pathogens.
 
 
 

 
 
Founded in 1897 in the Swiss Alps, Lonza today is a well-respected global company with more than 40 major manufacturing and R&D facilities and approximately 10,000 employees worldwide. The company generated sales of about CHF 3.6 billion in 2013 and is organized into two market-focused segments: Pharma & Biotech and Specialty Ingredients. Further information can be found at www.lonza.com.
 
About Adva-27a
 
Adva-27a is Sunshine Biopharma's lead anticancer compound, a Topoisomerase II inhibitor, small molecule that has recently been shown to be effective at killing Multidrug Resistant Breast Cancer cells, Small-Cell Lung Cancer cells, Uterine Sarcoma cells and Pancreatic Cancer cells (Published in ANTICANCER RESEARCH, Volume 32, Pages 4423-4432, October 2012).  Adva-27a is currently in the IND-Enabling stage of development. The original U.S. patent covering Adva-27a was issued on August 7, 2012 under U.S. patent number 8,236,935.  The Company is planning a Phase I clinical trial of Adva-27a for Pancreatic Cancer in parallel to the Phase I clinical trial of Adva-27a for multidrug resistant Breast Cancer to be conducted at McGill University's Jewish General Hospital in Montreal (Canada).
 
Safe Harbor Forward-Looking Statements
 
To the extent that statements in this press release are not strictly historical, including statements as to revenue projections, business strategy, outlook, objectives, future milestones, plans, intentions, goals, future financial conditions, future collaboration agreements, the success of the Company's development, events conditioned on stockholder or other approval, or otherwise as to future events, such statements are forward-looking, and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements contained in this release are subject to certain risks and uncertainties that could cause actual results to differ materially from the statements made.
 
For Additional Information:
 
Sunshine Biopharma Media Contacts:
Renmark Financial Communications Inc.
Robert Thaemlitz: rthaemlitz@renmarkfinancial.com
Joshua Ciarrocca: jciarrocca@renmarkfinancial.com
Tel.: (416) 644-2020 or (514) 939-3989
www.renmarkfinacial.com
 
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
 
Lonza Media Contacts:
Colleen Floreck, +1 201 316 9290, colleen.floreck@lonza.com
Constance Ward, +41 61 316 8840, constance.ward@lonza.com
 
Manufacturing will begin at Lonza’s Nansha, China facility with the remaining key steps to be conducted in Lonza’s high containment cytotoxic facility in Visp, Switzerland.

Nansha China
http://www.lonza.com/about-lonza/company-profile/locations-worldwide/nansha-china.aspx

Visp Switzerland
http://www.lonza.com/about-lonza/company-profile/locations-worldwide/visp-switzerland.aspx




SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals
 
 

 
We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.

 
Intellectual Property

 
We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
 
 
Advanomics

http://www.canada-companies-info.com/advanomics-corporationcorporation-advanomics-65q2
Advanomics Corporation, the Parent Company of Sunshine Biopharma
 

Head Office:

Advanomics Corporation

2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Canada

Tel: 514-764-9698
Fax: 514-764-9699
info@advanomics.com

Sunshine Biopharma Media Contacts:
Renmark Financial Communications Inc.
Robert Thaemlitz: rthaemlitz@renmarkfinancial.com
Joshua Ciarrocca: jciarrocca@renmarkfinancial.com
Tel.: (416) 644-2020 or (514) 939-3989
www.renmarkfinacial.com
 
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
 

Product Pipeline

Our product pipeline is comprised of the following anti-tumor compounds:

Adva-27a

Difluoro-Etoposide™
Entering Phase I later this year (Lead Compound)

 

Adva-R46

RNAi Anti-Cancer drug candidate
Soon to enter animal studies phase

 

Adva-33c

Difluoro-Carboplatin™
Currently in preclinical phase



 







SBFM Share Structure
 

From otcmarkets.com and SEC filings
The number of shares of the registrant’s only class of common stock issued and outstanding as of November 10, 2014, was 68,911,041 shares.
 

Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO




SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

http://corporatestock.com




Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Canada
Tel: 514-764-9698
Fax: 514-764-9699

http://sunshinebiopharma.com
info@sunshinebiopharma.com


 

 



 


 

 












































































 
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SBFM News: Information Statement - All Other (definitive) (def 14c) 06/23/2015 06:04:28 AM
SBFM News: Proxy Statement - Other Information (preliminary) (pre 14c) 06/08/2015 12:21:39 PM
SBFM News: Current Report Filing (8-k) 06/01/2015 12:57:12 PM
SBFM News: Quarterly Report (10-q) 05/07/2015 04:52:00 PM
SBFM News: CapRock Research Issues Analyst Report on Avra, Inc. (OTCQB: AVRN): Pioneering Product Innovation in Growing Bitcoin Market 04/08/2015 08:00:00 AM
PostSubject
#18925  Sticky Note All they are saying is NOISE. Clueless BooDog 02/10/15 06:05:42 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#20084   Put it in good,india very good,dr karithe very credible,ceo bombaykid 06/27/15 10:30:48 PM
#20083   He didnt even use vaseline,he did it greek style... Jimmythegreek 06/20/15 01:31:11 PM
#20082   STEVE N SLILATY FRAUDED ALL SHAREHOLDERS WITH EMPTY Angel21stCentury 06/19/15 01:17:34 PM
#20081   ITS ALL POTATOES STEVE N SLILATY IS A Angel21stCentury 06/19/15 01:13:46 PM
#20080   WHERE IS THE NEWS ON IND? ANSWER YOUR Angel21stCentury 06/19/15 01:11:27 PM
#20079   DR.STEVE N.SLILATY IS A DIRTY ROTTEN SCUMBAG Angel21stCentury 06/19/15 01:08:58 PM
#20078   Taking peoples money for helping the terminally ill,this Jimmythegreek 06/18/15 01:33:19 AM
#20077   I am sick of this ceo BS GaglioB 06/16/15 05:00:20 PM
#20076   Slilaty private investors all want their money back Jimmythegreek 06/16/15 01:47:01 PM
#20075   Not only laval,the whole world knows slilaty is Jimmythegreek 06/16/15 01:44:57 PM
#20074   Sllilaty is a top ranked criminal,on documents in Jimmythegreek 06/16/15 01:36:38 PM
#20073   Ceo the craphead scammer slilaty will pull the Cash Monster 06/14/15 02:32:07 PM
#20072   Ceo Steve Slilaty screwed us all while he Cash Monster 06/14/15 02:19:23 PM
#20071   Piece of crap steve slilaty never materialized an Cash Monster 06/11/15 10:39:59 PM
#20070   ceo crap head slilaty will end up in Cash Monster 06/11/15 10:37:17 PM
#20069   Yes you did,Ceo the turd craphead is a Cash Monster 06/11/15 01:00:22 PM
#20068   200M to 500M. But if you notice the BooDog 06/09/15 07:52:07 AM
#20067   did I read the news correctly? 700 millions vip1999 06/09/15 12:51:01 AM
#20066   Ceo the crap slilaty screwed us all and Cash Monster 06/08/15 12:23:41 PM
#20065   Nope,ceo is a well know scam artist,he runs Cash Monster 06/08/15 12:18:17 PM
#20064   Is there any hope for shareholders here? akiaki 06/07/15 06:12:04 PM
#20063   For further information please visit steve slilaty at Cash Monster 06/07/15 02:54:56 PM
#20062   The word is out in laval, ceo steve Cash Monster 06/07/15 02:45:00 PM
#20061   Ceo the turd craphead steve slilaty screwed all Cash Monster 06/07/15 02:38:57 PM
#20060   I bought over 1.5 million shares this week bombaykid 06/06/15 01:37:24 PM
#20059   This stock will go to 25cents with news bombaykid 06/04/15 02:24:14 PM
#20058   Will this return to the dollar range soon? akiaki 06/04/15 01:15:55 PM
#20057   I buy tuesday 400,000 Wednesday 550,000 verygood price,very bombaykid 06/04/15 11:41:31 AM
#20056   In india very good bombaykid 06/03/15 12:59:08 AM
#20055   Good timing in due for some parc ex clearsudden 06/01/15 10:50:48 PM
#20054   since 2012, .34 average. If they start to vip1999 06/01/15 10:27:32 PM
#20053   How long have you been invested here and akiaki 06/01/15 08:39:51 PM
#20052   I AM STUCKED, DON'T GET STUCK LIKE ME! vip1999 06/01/15 06:43:21 PM
#20051   Is there any hope here? any long term akiaki 06/01/15 06:30:24 PM
#20050   and the naan bread makes his re-emergence... I'm Kalinn 06/01/15 02:27:51 PM
#20049   News very good very big, bombaykid 06/01/15 04:22:37 AM
#20048   Very big news will be very good¥¥¥¥¥¥¥¥¥¥¥¥¥¥¥ bombaykid 06/01/15 04:18:53 AM
#20047   Everybody in india waiting for good opening bell bombaykid 06/01/15 04:13:27 AM
#20046   I buy good,Good morning everybody good,get ready for bombaykid 06/01/15 04:07:00 AM
#20045   Very good investment,very good low good cheap record bombaykid 06/01/15 04:04:28 AM
#20044   Factori buy all .04 very good¥¥¥¥¥¥¥¥¥¥¥¥¥¥¥¥ bombaykid 06/01/15 03:56:11 AM
#20043   India buy all,Dr.Karithe buy you all out bombaykid 06/01/15 03:51:56 AM
#20042   Are there any long term shareholders on this akiaki 05/30/15 08:14:23 PM
#20041   I'm not sure why they keep putting out Lavaliotis 05/29/15 02:55:55 PM
#20040   Camille must be scratching his head wondering why Kalinn 05/29/15 01:25:20 PM
#20039   That depends on the manipulation tactics Lavaliotis 05/29/15 10:53:42 AM
#20038   ping me when this round of dilution is BooDog 05/29/15 10:19:12 AM
#20037   Put that craphead slilaty in jail for fraud, Cash Monster 05/29/15 09:04:22 AM
#20036   Ceo Steve slilaty is a full blown scam Cash Monster 05/29/15 08:56:05 AM
#20035   Shhh. They might not know about the past. reportmyabuse 05/28/15 07:03:33 PM
PostSubject