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Sunshine Biopharma Inc. (SBFM)

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Last Post: 10/24/2014 9:15:00 PM - Followers: 171 - Board type: Free - Posts Today: 13








 



 

 


"The Future Of Medicine"
 

 




 
Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 





 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 
 


Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697




 



Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.


Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options




 





 

 



 

 
 
Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).




The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.
 






Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug







 




OTCBB NEWS link http://www.otcbb.com/asp/Info_Center.asp
Dec 10, 2012 Sunshine Biopharma Completes Another IND-Enabling Study: Adva-27a Is Found to Be Effective Against Multidrug Resistant Uterine Cancer Cells
Dec 5, 2012 PennyTrackers.com Daily Watchlist: Sunshine Biopharma Inc. (OTCBB: SBFM), Biostar Pharmaceuticals, Inc. (NASDAQ: BSPM), Axia Group's (PINKSHEETS: AGIJ), Terralene Fuels Corporation (OTCQB: GSPT)
Dec 4, 2012 Sunshine Biopharma Completes Six IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Nov 27, 2012 Advanomics Corporation, the Parent Company of Sunshine Biopharma, Completes Acquisition of Adva-27a Patents
Nov 25, 2012 Insidebulls.com Volume Alerts: Medizone International (OTCQB: MZEI), SportsQuest, Inc. (PINKSHEETS: SPQS), Sunshine Biopharma Inc. (OTCBB: SBFM), Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH)
Nov 13, 2012 Sunshine Biopharma Initiates IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Oct 9, 2012 Sunshine Biopharma Receives Scale-Up Manufacturing Protocol for Its Lead Anti-Cancer Compound, Adva-27a
Sept 25, 2012 Les résultats des recherches précliniques sur l'Adva-27a de Sunshine Biopharma, seront publiés dans l'édition d'octobre d'ANTICANCER RESEARCH
Sept 25, 2012 Sunshine Biopharma's Adva-27a Preclinical Research Results to Be Published in October Issue of ANTICANCER RESEARCH
Sept 20, 2012 Breast Cancer News: Geron Drug Fails, Herceptin® May Increase Heart Problems, Sunshine Biopharma Heading for Clinical Trials
 

11/16/11 Sunshine Biopharma announces successful completion of preclinical studies for Adva-27a, the company's lead anti-cancer compound

10/5/11 Sunshine Biopharma's anti-cancer compound, Adva-27a, found to be a strong Topoisomerase II inhibitor

8/30/11 Clearance of Sunshine Biopharma's anti-cancer compound, Adva-27a, does not involve a toxic intermediate

8/10/11  Sunshine Biopharma Aims to Follow in Herceptin's Footsteps

8/2/11  Sunshine Biopharma Looking to Mimic Roche's Billion Dollar Cancer Drug Success





SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals
 
 

 
We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.

 
Intellectual Property

 
We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
 
 
Advanomics

http://www.canada-companies-info.com/advanomics-corporationcorporation-advanomics-65q2
Advanomics Corporation, the Parent Company of Sunshine Biopharma
 

Head Office:

Advanomics Corporation

2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Canada

Tel: 514-764-9698
Fax: 514-764-9699
info@advanomics.com


For specific information, please contact:

Mr. Camille Sebaaly
Tel: 514-814-0464
Fax: 450-689-6397
camille.sebaaly@advanomics.com


Product Pipeline

Our product pipeline is comprised of the following anti-tumor compounds:

Adva-27a

Difluoro-Etoposide™
Entering Phase I later this year (Lead Compound)

 

Adva-R46

RNAi Anti-Cancer drug candidate
Soon to enter animal studies phase

 

Adva-33c

Difluoro-Carboplatin™
Currently in preclinical phase



 







SBFM Share Structure
 

From otcmarkets.com and SEC filings
The number of shares of the registrant’s only class of common stock issued and outstanding as of August 12, 2014, was 68,270,961 shares.
 

Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO




SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

http://corporatestock.com




Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Canada
Tel: 514-764-9698
Fax: 514-764-9699

http://sunshinebiopharma.com
info@sunshinebiopharma.com


 

 



 


 

 












































































 
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Wiki
SBFM News: Quarterly Report (10-q) 08/12/2014 05:26:36 PM
SBFM News: Prospectus Filed Pursuant to Rule 424(b)(3) (424b3) 07/28/2014 04:05:06 PM
SBFM News: Notice of Effectiveness (effect) 07/24/2014 06:01:50 AM
SBFM News: Securities Registration Statement (s-1/a) 07/03/2014 06:02:21 AM
SBFM News: Sunshine Biopharma's Adva-27a Featured in 2014 Worldwide Uterine Cancer Report for Its Effectiveness Against Multidrug Resist... 06/09/2014 08:00:00 AM
PostSubject
#17847  Sticky Note SUNSHINE BIOPHARMA INC (quick info) BooDog 10/07/14 07:08:41 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#17963   The toilet bowl is the only thing you Cash Monster 10/24/14 09:15:00 PM
#17962   After 5 years Ceo the turd slilaty is Cash Monster 10/24/14 08:56:19 PM
#17961   And? That was 3 years ago?can you please Cash Monster 10/24/14 08:53:23 PM
#17960   Your disrespectful, thats not true, ceo completed preclinical ThunderStriker 10/24/14 07:29:54 PM
#17959   This is the real deal turd Cash Monster 10/24/14 07:16:14 PM
#17958   Ceo slilaty accomplished a rotten bananna and lied Cash Monster 10/24/14 07:09:56 PM
#17957   Shareholders meeting is held every year in mille Cash Monster 10/24/14 06:45:19 PM
#17956   Are any developements on the way???? Where do ThunderStriker 10/24/14 05:19:47 PM
#17955   Locked and loaded ready to strike like thunder ThunderStriker 10/24/14 05:12:45 PM
#17954   WE LOVE YOU BIOMANBABA,YOU WILL ALWAYS BE THE Angel21stCentury 10/24/14 03:35:55 PM
#17953   SUNSHINE'S ADVA-27A MIRACLE DRUG IS THE REAL DEAL$$$$ Angel21stCentury 10/24/14 06:43:20 AM
#17952   WELCOME ABOARD,FIRE IN THE HOLE$$$$$$$$$$$$$$$$$ Angel21stCentury 10/24/14 06:41:02 AM
#17951   HERE COMES THE CURE TO BREAST CANCER ADVA-27A Angel21stCentury 10/24/14 06:39:45 AM
#17950   He is still around, this ir firm is sharp. ThunderStriker 10/23/14 09:06:24 PM
#17949   Flying over sbfm about to have fun ThunderStriker 10/23/14 08:57:22 PM
#17948   ceo slilaty burned this turd to the ground Cash Monster 10/23/14 07:58:47 PM
#17947   If this turd was real we would be Cash Monster 10/23/14 07:51:42 PM
#17946   That's right !! Dump all your shares !! Gordon Buffett 10/23/14 04:12:23 PM
#17945   DON'T CATCH THE FALLING KNIFE!!! Zephadiah 10/23/14 03:05:58 PM
#17944   PUMP AND DUMP SCAM STOCK!!! BEWARE TRADERS!!! Zephadiah 10/23/14 03:04:44 PM
#17943   ADVA-27A THE WORLDS NEW HOPE FOR BREAST CANCER Angel21stCentury 10/22/14 06:28:31 PM
#17942   TAKE OUT THE CURE TO BREAST CANCER ON Angel21stCentury 10/22/14 06:08:24 PM
#17941   Slilaty the turd never accomplished anything in his career Cash Monster 10/22/14 03:36:56 PM
#17940   Its about time, Une Bonne Debarras Cash Monster 10/22/14 03:22:20 PM
#17939   If this turd has a miracle cancer drug Cash Monster 10/22/14 03:07:37 PM
#17938   THE BIG BOOT SALUTE FOR CAMILLE SEBAALY CFO,YOUR Angel21stCentury 10/20/14 03:14:26 PM
#17937   SBFM WILL EXPLODE CAMILLE SEBAALY CFO IS OUT Angel21stCentury 10/20/14 03:13:33 PM
#17936   CAMILLE SEBAALY CFO GOT THROWN OUT OF OFFICE Angel21stCentury 10/20/14 03:11:24 PM
#17935   CALL YOURSELF, IR FIRM TOLD ME CAMILLE SEBAALY Angel21stCentury 10/20/14 03:07:24 PM
#17934   How do you know this? rabbip 10/20/14 02:54:31 PM
#17933   CAMILLE SEBAALY CFO JUST GOT FIRED Angel21stCentury 10/20/14 12:22:11 PM
#17932   ANSWER YOUR PHONE CAMILLE SEBAALY CFO,SHAREHOLDERS ALL WANT Angel21stCentury 10/20/14 12:20:13 PM
#17931   TAKE OUT IND AND BLAST OFF$$$$$$$$$$$$$$ Angel21stCentury 10/20/14 12:09:59 PM
#17930   Camille the turd is useless, better talking to Cash Monster 10/19/14 05:36:22 PM
#17929   The turd slilaty never accomplished anything all his career Cash Monster 10/19/14 03:54:27 PM
#17928   "In addition to the generic pharmaceutical business unit Angel21stCentury 10/19/14 11:08:42 AM
#17927   GREAT TO SEE Y'ALL,HANG ON TIGHT DR.STEVE SLILATY Angel21stCentury 10/18/14 06:00:30 PM
#17926   Sunshine's portal at Renmark: Kalinn 10/18/14 12:57:00 PM
#17925   Something else I thought of, IF they are BooDog 10/18/14 07:57:39 AM
#17924   If it is just bad management, it will vip1999 10/18/14 02:28:46 AM
#17923   Anything ever going to happen here? I had Darwinian 10/17/14 09:57:32 PM
#17922   would be a step in the right direction... macnqueso 10/17/14 08:51:24 PM
#17921   It is in a recent pr about locating BooDog 10/17/14 08:26:46 PM
#17920   how about just getting adva27a into clinical stage macnqueso 10/17/14 08:03:13 PM
#17919   Every year I wondered where the stock would Kalinn 10/17/14 06:50:53 PM
#17918   Nice to see the bottom has been reached reportmyabuse 10/17/14 01:14:24 PM
#17917   BINGO!!!!!!Experimental Studies Angel21stCentury 10/17/14 05:18:58 AM
#17916   HELLO!!!http://ar.iiarjournals.org/search?fulltext=sunshine+biopharma&submit=yes Angel21stCentury 10/17/14 05:12:13 AM
#17915   THE HOLY GRAIL IN CANCER RESEARCH ADVA-27A NOVEL Angel21stCentury 10/16/14 06:01:30 PM
#17914   HOLD ON FOLKS,THE CURE TO BREAST CANCER IS HERE Angel21stCentury 10/16/14 04:54:19 PM
PostSubject