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Sunshine Biopharma Inc. (SBFM)

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Last Post: 7/25/2014 9:22:35 AM - Followers: 173 - Board type: Free - Posts Today: 7




"The Future Of Medicine"

Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options



Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.

Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug


OTCBB NEWS link http://www.otcbb.com/asp/Info_Center.asp
Dec 10, 2012 Sunshine Biopharma Completes Another IND-Enabling Study: Adva-27a Is Found to Be Effective Against Multidrug Resistant Uterine Cancer Cells
Dec 5, 2012 PennyTrackers.com Daily Watchlist: Sunshine Biopharma Inc. (OTCBB: SBFM), Biostar Pharmaceuticals, Inc. (NASDAQ: BSPM), Axia Group's (PINKSHEETS: AGIJ), Terralene Fuels Corporation (OTCQB: GSPT)
Dec 4, 2012 Sunshine Biopharma Completes Six IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Nov 27, 2012 Advanomics Corporation, the Parent Company of Sunshine Biopharma, Completes Acquisition of Adva-27a Patents
Nov 25, 2012 Insidebulls.com Volume Alerts: Medizone International (OTCQB: MZEI), SportsQuest, Inc. (PINKSHEETS: SPQS), Sunshine Biopharma Inc. (OTCBB: SBFM), Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH)
Nov 13, 2012 Sunshine Biopharma Initiates IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Oct 9, 2012 Sunshine Biopharma Receives Scale-Up Manufacturing Protocol for Its Lead Anti-Cancer Compound, Adva-27a
Sept 25, 2012 Les résultats des recherches précliniques sur l'Adva-27a de Sunshine Biopharma, seront publiés dans l'édition d'octobre d'ANTICANCER RESEARCH
Sept 25, 2012 Sunshine Biopharma's Adva-27a Preclinical Research Results to Be Published in October Issue of ANTICANCER RESEARCH
Sept 20, 2012 Breast Cancer News: Geron Drug Fails, Herceptin® May Increase Heart Problems, Sunshine Biopharma Heading for Clinical Trials

11/16/11 Sunshine Biopharma announces successful completion of preclinical studies for Adva-27a, the company's lead anti-cancer compound

10/5/11 Sunshine Biopharma's anti-cancer compound, Adva-27a, found to be a strong Topoisomerase II inhibitor

8/30/11 Clearance of Sunshine Biopharma's anti-cancer compound, Adva-27a, does not involve a toxic intermediate

8/10/11  Sunshine Biopharma Aims to Follow in Herceptin's Footsteps

8/2/11  Sunshine Biopharma Looking to Mimic Roche's Billion Dollar Cancer Drug Success

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals


SBFM Share Structure

From otcmarkets.com

Outstanding 51,391,092 a/o Nov 07, 2012
Float 13,916,529 a/o Mar 15, 2012
Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f


Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Tel: 514-764-9698
Fax: 514-764-9699





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SBFM News: Notice of Effectiveness (effect) 07/24/2014 06:01:50 AM
SBFM News: Securities Registration Statement (s-1/a) 07/03/2014 06:02:21 AM
SBFM News: Sunshine Biopharma's Adva-27a Featured in 2014 Worldwide Uterine Cancer Report for Its Effectiveness Against Multidrug Resist... 06/09/2014 08:00:00 AM
SBFM News: Securities Registration Statement (s-1) 05/22/2014 04:48:18 PM
SBFM News: Sunshine Biopharma Announces Issuance of Notice of Allowance for the Patent Application Covering Adva-27a Anticancer Compound... 05/12/2014 08:00:00 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#10706  Sticky Note SUNSHINE BIOPHARMA INC (quick info) BooDog 09/12/13 07:25:24 AM
#16910   WHO GIVES A DARN OF RE-DOMICILE?WHERE IS MANUFACTURING Angel21stCentury 07/25/14 09:22:35 AM
#16909   GM BD,WHERE IS ADVA-27A BREAKTHROUGH IN THE CLINIIC?? Angel21stCentury 07/25/14 09:13:26 AM
#16906   Slilaty the turdmaster accomplished 0 in 5 years, Cash Monster 07/25/14 07:54:36 AM
#16905   This turd is still at square one, Looks Cash Monster 07/25/14 07:49:02 AM
#16904   Stand by. EFFECT Documents Notice of Effectiveness BooDog 07/25/14 05:32:26 AM
#16903   Slilaty the turdmaster never materialized an event all Cash Monster 07/24/14 11:27:38 PM
#16902   Keep on dreaming angel.... Ceo has no guts, Cash Monster 07/24/14 11:20:11 PM
#16901   Steve Slilaty is know as a real joke. Cash Monster 07/24/14 11:11:46 PM
#16900   Looks like SBFM is turd status, Ceo is Cash Monster 07/24/14 11:06:33 PM
#16899   THEY CAN BE DOMICILED ON THE MOON FOR Angel21stCentury 07/24/14 03:20:26 PM
#16898   CALL CAMILLA USELESS SEBAALY 1-514-814-0464 SHE BURNED AND Angel21stCentury 07/24/14 03:09:25 PM
#16897   We all want ind ... Just saying is reginaliberta 07/24/14 02:12:21 PM
#16896   NO THAT PART IS POTATOES, WE WANT IND Angel21stCentury 07/24/14 01:47:07 PM
#16895   Does this mean redomicile is concluded and finalized ? reginaliberta 07/24/14 12:35:54 PM
#16894   YOU CANT STOP THE POWER OF ADVA-27A NOVEL Angel21stCentury 07/24/14 08:40:59 AM
#16893   "MIRACLE HOLY GRAIL STATUS BREAKTHROUGH IS UNDERWAY" Angel21stCentury 07/24/14 08:34:39 AM
#16892   ADVA-27A"THE WORLD'S NEW HOPE FOR TERMINALLY ILL CANCER PATIENTS" Angel21stCentury 07/24/14 08:18:03 AM
#16891   ADVA-27A NOVEL LEAD ANTI-CANCER DRUG WILL SHOCK THE WORLD Angel21stCentury 07/24/14 08:09:23 AM
#16890   GET READY FOR THE BIGGEST CANCER BREAKTHROUGH ON EARTH$$$$$$$ Angel21stCentury 07/24/14 07:59:20 AM
#16889   WAKE UP AND GET READY FOR BLAST OFF$$$$$$$$$$$$ Angel21stCentury 07/24/14 07:56:30 AM
#16888   SUNY Chancellor praises Upstate Cancer Center's breakthrough ... Angel21stCentury 07/23/14 06:24:39 PM
#16887   ITS A BREAKTHROUGH IN THE CLINIC$$$ Dr. Susannah Angel21stCentury 07/22/14 03:16:40 PM
#16885   What breakthrough are you talking about?? SBFM is Cash Monster 07/22/14 02:58:52 PM
#16884   Sounds like this turd will explode like a Cash Monster 07/22/14 02:56:45 PM
#16883   SOUND ALL ALARMS BD,A BREAKTHROUGH IS ON THE WAY$$$$ Angel21stCentury 07/21/14 04:53:12 PM
#16882   HAIL BREAKTHROUGH MIRACLE DRUG ADVA-27A$$$$$$$$$$$$ Angel21stCentury 07/21/14 04:49:36 PM
#16881   PUT ON YOUR DANCING SHOES,ITS PARTY TIME$$$$$$$ Angel21stCentury 07/21/14 04:46:12 PM
#16880   strange indeed Kalinn 07/21/14 04:03:02 PM
#16879   ITS TIME TO WAKE UP$$$$$$$$$$$$$$$ Angel21stCentury 07/21/14 02:24:15 PM
#16878   WE WANT NEWS ON IND TO THE FDA Angel21stCentury 07/21/14 02:18:50 PM
#16877   A BREAKTHROUGH IN THE CLINIC IS ON THE WAY Angel21stCentury 07/20/14 10:23:34 PM
#16876   This turd will explode like a hot tacos indigestion. Cash Monster 07/20/14 08:29:15 PM
#16875   What the hell is going on over here?? Cash Monster 07/20/14 08:23:11 PM
#16874   HOLD ON TO YOUR UNDERWEARS$$$$$$$$$ Angel21stCentury 07/19/14 08:12:01 PM
#16873   GET READY BD WE ARE GOING TO THE Angel21stCentury 07/19/14 08:02:04 PM
#16872   Still here SB. Just a reed in the BooDog 07/19/14 04:58:21 PM
#16871   GET READY FOR A CANCER CURE ADVA-27A NOVEL Angel21stCentury 07/19/14 02:02:26 PM
#16870   From 7/16-7/18 I see only about half a Stockbuilder 07/19/14 09:45:52 AM
#16869   AN INTERNATIONAL CANCER BREAKTHROUGH IS ON THE WAY$$$$$$$$$$ Angel21stCentury 07/19/14 09:43:52 AM
#16868   DR.STEVE SLILATY CEO WILL SHOCK THE WORLD$$$$$$$ Angel21stCentury 07/19/14 09:40:36 AM
#16867   as strange as it may sound, I actually vip1999 07/19/14 09:19:26 AM
#16866   Why are my dreams of riches melting? Oh, reportmyabuse 07/18/14 10:06:02 PM
#16865   WE LOVE YOU BIOMANBABA,ITS TIME TO POUND THE TABLE$$$$$$$$ Angel21stCentury 07/18/14 10:01:54 PM
#16864   ITS TIME TO MARCH TO DOLLARLAND$$$$$$$$$$$ Angel21stCentury 07/18/14 10:00:41 PM
#16863   HERE COMES THE POWER OF ADVA-27A$$$$$$$$$$$$$$$$$$ Angel21stCentury 07/18/14 09:54:23 PM
#16862   YOU HAVENT SEEN ANYTHNG YET,HOLD ON BUDDY WE Angel21stCentury 07/18/14 09:48:00 PM
#16861   Best thing about today is that it was Citrati 07/18/14 06:18:13 PM
#16860   TIME TO MOVE YOUR ASS AND DO SOMETHING$$$$$ Angel21stCentury 07/18/14 12:06:35 PM
#16859   ROCKET BOOSTERS ALL ACTIVATED$$$$$$$$$ Angel21stCentury 07/17/14 10:04:15 PM
#16858   HAIL BREAKTHROUGH HOLY GRAIL ADVA-27A OF CANCER RESEARCH Angel21stCentury 07/17/14 09:59:36 PM