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Sunshine Biopharma Inc. (SBFM)

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"The Future Of Medicine"


Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 


Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697


Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options





Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.

Check out SBFM's drug Adva-27a (27a) vs the leading chem drug Etoposide (2) - results are better in every category except two. And in the multi drug resistance breast cancer category (MCF7R) it's over 3x more effective. 

Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.

Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug


November 19, 2014
Montreal, Quebec, Canada -- (Marketwire) -- Sunshine Biopharma Inc. (OTCQB: “SBFM”), a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, announced today an agreement with Lonza, a leading development and manufacturing company, for the manufacture of its anti-cancer drug, Adva-27a.  Lonza’s expertise and experience in small molecule development and manufacturing of active pharmaceutical ingredients, was an ideal fit for Sunshine’s Adva-27a.  Lonza’s manufacturing capacity ranges from gram quantities for process validation to kilogram amounts for clinical trials and ton quantities for commercialization.  Manufacturing will begin at Lonza’s Nansha, China facility with the remaining key steps to be conducted in Lonza’s high containment cytotoxic facility in Visp, Switzerland.
“We are delighted to have a global leader like Lonza as our manufacturing partner,” said Dr. Steve N. Slilaty, President and CEO of Sunshine Biopharma.  “We have made significant recent strides in terms of research results showing the effectiveness of our lead compound against cancer cells as well as in our manufacturing and recent fund raising efforts.”
“We are very excited to be working with Sunshine Biopharma on the development of their promising anti-cancer compound”, said James Leresche, Ph.D., Head of Lonza’s Chemical Development Services. “This development project is an example of Lonza’s support and commitment to emerging companies with innovative and potentially life-saving treatments like Adva-27a.”
About Lonza
Lonza is one of the world’s leading and most-trusted suppliers to the pharmaceutical, biotech and specialty ingredients markets. We harness science and technology to create products that support safer and healthier living and that enhance the overall quality of life.
Not only are we a custom manufacturer and developer, Lonza also offers services and products ranging from active pharmaceutical ingredients and stem-cell therapies to drinking water sanitizers, from the vitamin B compounds and organic personal care ingredients to agricultural products, and from industrial preservatives to microbial control solutions that combat dangerous viruses, bacteria and other pathogens.

Founded in 1897 in the Swiss Alps, Lonza today is a well-respected global company with more than 40 major manufacturing and R&D facilities and approximately 10,000 employees worldwide. The company generated sales of about CHF 3.6 billion in 2013 and is organized into two market-focused segments: Pharma & Biotech and Specialty Ingredients. Further information can be found at www.lonza.com.
About Adva-27a
Adva-27a is Sunshine Biopharma's lead anticancer compound, a Topoisomerase II inhibitor, small molecule that has recently been shown to be effective at killing Multidrug Resistant Breast Cancer cells, Small-Cell Lung Cancer cells, Uterine Sarcoma cells and Pancreatic Cancer cells (Published in ANTICANCER RESEARCH, Volume 32, Pages 4423-4432, October 2012).  Adva-27a is currently in the IND-Enabling stage of development. The original U.S. patent covering Adva-27a was issued on August 7, 2012 under U.S. patent number 8,236,935.  The Company is planning a Phase I clinical trial of Adva-27a for Pancreatic Cancer in parallel to the Phase I clinical trial of Adva-27a for multidrug resistant Breast Cancer to be conducted at McGill University's Jewish General Hospital in Montreal (Canada).
Safe Harbor Forward-Looking Statements
To the extent that statements in this press release are not strictly historical, including statements as to revenue projections, business strategy, outlook, objectives, future milestones, plans, intentions, goals, future financial conditions, future collaboration agreements, the success of the Company's development, events conditioned on stockholder or other approval, or otherwise as to future events, such statements are forward-looking, and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements contained in this release are subject to certain risks and uncertainties that could cause actual results to differ materially from the statements made.
For Additional Information:
Sunshine Biopharma Media Contacts:
Renmark Financial Communications Inc.
Robert Thaemlitz: rthaemlitz@renmarkfinancial.com
Joshua Ciarrocca: jciarrocca@renmarkfinancial.com
Tel.: (416) 644-2020 or (514) 939-3989
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
Lonza Media Contacts:
Colleen Floreck, +1 201 316 9290, colleen.floreck@lonza.com
Constance Ward, +41 61 316 8840, constance.ward@lonza.com
Manufacturing will begin at Lonza’s Nansha, China facility with the remaining key steps to be conducted in Lonza’s high containment cytotoxic facility in Visp, Switzerland.

Nansha China

Visp Switzerland

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals

We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.

Intellectual Property

We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.

Advanomics Corporation, the Parent Company of Sunshine Biopharma

Head Office:

Advanomics Corporation

2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8

Tel: 514-764-9698
Fax: 514-764-9699

Sunshine Biopharma Media Contacts:
Renmark Financial Communications Inc.
Robert Thaemlitz: rthaemlitz@renmarkfinancial.com
Joshua Ciarrocca: jciarrocca@renmarkfinancial.com
Tel.: (416) 644-2020 or (514) 939-3989
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com

Product Pipeline

Our product pipeline is comprised of the following anti-tumor compounds:


Entering Phase I later this year (Lead Compound)



RNAi Anti-Cancer drug candidate
Soon to enter animal studies phase



Currently in preclinical phase


SBFM Share Structure

From otcmarkets.com and SEC filings
The number of shares of the registrant’s only class of common stock issued and outstanding as of November 10, 2014, was 68,911,041 shares.

Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f


Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Tel: 514-764-9698
Fax: 514-764-9699







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SBFM News: Current Report Filing (8-k) 02/24/2015 12:44:31 PM
SBFM News: Statement of Changes in Beneficial Ownership (4) 01/22/2015 11:49:09 AM
SBFM News: Current Report Filing (8-k) 11/19/2014 04:01:04 PM
SBFM News: Quarterly Report (10-q) 11/12/2014 07:01:12 AM
#18925  Sticky Note All they are saying is NOISE. Clueless BooDog 02/10/15 06:05:42 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#19052   Speriamo non va finire gambe a l'aria. Slilaty piange reginaliberta 03/03/15 10:13:50 PM
#19051   Is it 18 weeks yet? Did Lonza receive reginaliberta 03/03/15 10:07:57 PM
#19050   stopped throwing money at this loser long time Kalinn 03/02/15 04:50:13 PM
#19049   Somebody knows something bro. Could be you. Could reportmyabuse 03/02/15 12:47:03 PM
#19048   Just passed by bankrupt dollar store called garmen, Jimmythegreek 03/01/15 05:45:15 PM
#19047   Re,you could be right,we might have a chance Jimmythegreek 03/01/15 12:43:14 PM
#19046   Buy now and lose it all tomorrow, its Cash Monster 02/28/15 12:38:47 AM
#19045   Profits from where, flushing toilets full of turd,this Cash Monster 02/28/15 12:35:44 AM
#19044   keep dreaming, it doesn't cost anything so who cares Kalinn 02/27/15 07:19:09 PM
#19043   I think it's gonna happen, easy. Things look reportmyabuse 02/27/15 04:10:49 PM
#19042   Bro, there will be plenty of time for reportmyabuse 02/27/15 12:57:37 PM
#19041   lol Kalinn 02/27/15 11:45:54 AM
#19040   Nah. This could very well be the next reportmyabuse 02/27/15 10:50:28 AM
#19039   Ind filing got flushed down the toilet with Cash Monster 02/27/15 07:43:45 AM
#19038   Not that there's anything wrong with that though, reportmyabuse 02/26/15 03:26:43 PM
#19037   Let's just hope that he's willing to work reportmyabuse 02/26/15 01:20:37 PM
#19035   Now that's not nice. He sure did better than clearsudden 02/26/15 07:47:38 AM
#19034   This clown Merzouki never accomplished anything all his career Cash Monster 02/26/15 02:47:13 AM
#19033   Sounds good, and I can't even read French. reportmyabuse 02/25/15 02:15:51 PM
#19032   Impossible I heard she was fired because of Gordon Buffett 02/25/15 08:59:51 AM
#19031   Yes once they file we can all go clearsudden 02/25/15 07:50:06 AM
#19030   Just in case you guys have any wet vip1999 02/25/15 12:50:23 AM
#19029   http://igb.umontreal.ca/bottins/index.html Abderrazzak Merzouki Kalinn 02/24/15 09:24:19 PM
#19028   I don't know but they'd better steal them reportmyabuse 02/24/15 08:15:54 PM
#19027   Laval is still waiting for garmen labs to Cash Monster 02/24/15 05:22:25 PM
#19026   Its very simple,take a crap and dont forget Cash Monster 02/24/15 05:15:03 PM
#19025   I don't understand how this works now? Gordon Buffett 02/24/15 05:01:18 PM
#19024   Watch out people this new board member Dr. Jimmythegreek 02/24/15 04:48:07 PM
#19023   Michele has to start stripping to make some Gordon Buffett 02/24/15 04:41:55 PM
#19022   Adva works better once in the toilet bowl Cash Monster 02/24/15 04:30:10 PM
#19021   The Dr and Camille slapped rocket boosters on Gordon Buffett 02/24/15 04:13:25 PM
#19020   The Dr and Camille slapped rocket boosters on Gordon Buffett 02/24/15 04:13:24 PM
#19019   She was useless and got flushed down the Cash Monster 02/24/15 03:59:21 PM
#19018   Does anyone know if she was hot? Gordon Buffett 02/24/15 01:48:28 PM
#19017   SELL EVERYTHING !!! Gordon Buffett 02/24/15 01:47:55 PM
#19016   you are right plus the dollar store closed clearsudden 02/24/15 01:45:40 PM
#19015   This is very confusing, if she's gone who Gordon Buffett 02/24/15 01:39:21 PM
#19014   She got flushed down the toilet bowl with Cash Monster 02/24/15 01:34:41 PM
#19013   Michele was completely useless!! She was in charge Gordon Buffett 02/24/15 01:19:21 PM
#19012   i have no idea who this chick Michele Gordon Buffett 02/24/15 01:18:23 PM
#19011   was Michel camil's girlfriend? Gordon Buffett 02/24/15 01:13:23 PM
#19010   NEWS OUT !! Change in officers. Gordon Buffett 02/24/15 01:09:32 PM
#19009   We need you Billy Bob Cash Monster 02/24/15 10:35:22 AM
#19008   Billy the rats in newyork will take over Cash Monster 02/24/15 10:34:11 AM
#19007   the Dr and Camille need money for hair Gordon Buffett 02/23/15 02:30:39 PM
#19006   All she needs is CASH$$$$$$$$$$$$$$$ And she will Cash Monster 02/22/15 09:39:57 PM
#19005   He is only good for collecting wild rats Cash Monster 02/22/15 09:35:11 PM
#19003   Big Bad Bob ... https://www.youtube.com/watch?v=yNM64VP2JBw BooDog 02/22/15 11:33:46 AM
#19002   Where are you billycash,we need you badly Jimmythegreek 02/22/15 08:21:20 AM
#19001   She is in jail for life Jimmythegreek 02/21/15 07:58:34 AM