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Sunshine Biopharma Inc. (SBFM)

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Last Post: 9/30/2014 10:44:49 PM - Followers: 170 - Board type: Free - Posts Today: 0




"The Future Of Medicine"

Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options



Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.

Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug


Dec 10, 2012 Sunshine Biopharma Completes Another IND-Enabling Study: Adva-27a Is Found to Be Effective Against Multidrug Resistant Uterine Cancer Cells
Dec 5, 2012 Daily Watchlist: Sunshine Biopharma Inc. (OTCBB: SBFM), Biostar Pharmaceuticals, Inc. (NASDAQ: BSPM), Axia Group's (PINKSHEETS: AGIJ), Terralene Fuels Corporation (OTCQB: GSPT)
Dec 4, 2012 Sunshine Biopharma Completes Six IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Nov 27, 2012 Advanomics Corporation, the Parent Company of Sunshine Biopharma, Completes Acquisition of Adva-27a Patents
Nov 25, 2012 Volume Alerts: Medizone International (OTCQB: MZEI), SportsQuest, Inc. (PINKSHEETS: SPQS), Sunshine Biopharma Inc. (OTCBB: SBFM), Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH)
Nov 13, 2012 Sunshine Biopharma Initiates IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Oct 9, 2012 Sunshine Biopharma Receives Scale-Up Manufacturing Protocol for Its Lead Anti-Cancer Compound, Adva-27a
Sept 25, 2012 Les résultats des recherches précliniques sur l'Adva-27a de Sunshine Biopharma, seront publiés dans l'édition d'octobre d'ANTICANCER RESEARCH
Sept 25, 2012 Sunshine Biopharma's Adva-27a Preclinical Research Results to Be Published in October Issue of ANTICANCER RESEARCH
Sept 20, 2012 Breast Cancer News: Geron Drug Fails, Herceptin® May Increase Heart Problems, Sunshine Biopharma Heading for Clinical Trials

11/16/11 Sunshine Biopharma announces successful completion of preclinical studies for Adva-27a, the company's lead anti-cancer compound

10/5/11 Sunshine Biopharma's anti-cancer compound, Adva-27a, found to be a strong Topoisomerase II inhibitor

8/30/11 Clearance of Sunshine Biopharma's anti-cancer compound, Adva-27a, does not involve a toxic intermediate

8/10/11  Sunshine Biopharma Aims to Follow in Herceptin's Footsteps

8/2/11  Sunshine Biopharma Looking to Mimic Roche's Billion Dollar Cancer Drug Success

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals


SBFM Share Structure


Outstanding 51,391,092 a/o Nov 07, 2012
Float 13,916,529 a/o Mar 15, 2012
Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Tel: 514-764-9698
Fax: 514-764-9699




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SBFM News: Quarterly Report (10-q) 08/12/2014 05:26:36 PM
SBFM News: Prospectus Filed Pursuant to Rule 424(b)(3) (424b3) 07/28/2014 04:05:06 PM
SBFM News: Notice of Effectiveness (effect) 07/24/2014 06:01:50 AM
SBFM News: Securities Registration Statement (s-1/a) 07/03/2014 06:02:21 AM
SBFM News: Sunshine Biopharma's Adva-27a Featured in 2014 Worldwide Uterine Cancer Report for Its Effectiveness Against Multidrug Resist... 06/09/2014 08:00:00 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#10706  Sticky Note SUNSHINE BIOPHARMA INC (quick info) BooDog 09/12/13 07:25:24 AM
#17725   THIS IS A BIG FAT GARBAGE CAN$$$$$$$$$$$$$ Angel21stCentury 09/30/14 10:44:49 PM
#17724   WHERE IS THE NEWS ON IND??????? Angel21stCentury 09/30/14 10:30:13 PM
#17723   ALL THEY HAVE IS POTATOES FROM PEI$$$$$$$$ NOT Angel21stCentury 09/30/14 10:29:00 PM
#17722   They still have close to 2 million in null 09/30/14 09:12:33 PM
#17721   They still have close to 2 million in Doc_John 09/30/14 08:36:35 PM
#17720   they need to download the generic plan before Kalinn 09/30/14 05:53:19 PM
#17719   May take that long just to implement the BooDog 09/30/14 05:38:39 PM
#17718   Well now they're stuck selling generics to raise Kalinn 09/30/14 05:36:50 PM
#17717   Trying to shake someone out of their shares? BooDog 09/30/14 05:18:09 PM
#17716   Lead and execute ! reginaliberta 09/30/14 04:51:05 PM
#17715   Cash, .... No shares maybe combination of both. reginaliberta 09/30/14 04:49:05 PM
#17714   Great entry point for bottom feeders reginaliberta 09/30/14 04:43:41 PM
#17713   If he doesn't choose a Cro fast and reginaliberta 09/30/14 04:41:03 PM
#17712   slilaty is ready to bankrupt this turd. Cash Monster 09/30/14 04:37:39 PM
#17711   SS and CS better wake up! reginaliberta 09/30/14 04:32:28 PM
#17710   Go go go turd slilaty run it to Cash Monster 09/30/14 04:22:34 PM
#17709   Well this orange has been juiced pretty hard, Kalinn 09/30/14 04:16:40 PM
#17708   wishful thinking but I have no clue what's Kalinn 09/30/14 04:13:13 PM
#17707   of course it does because you think your Gordon Buffett 09/30/14 03:56:18 PM
#17706   As have said, I am in it till franky1 09/30/14 03:13:57 PM
#17705   trust a junk shares should never be matched. Gordon Buffett 09/30/14 03:00:35 PM
#17704   lesson learnt, should never have trusted a friend's DD Kalinn 09/30/14 02:18:57 PM
#17703   They should just declare bankruptcy and end it Kalinn 09/30/14 02:17:32 PM
#17702   with all the fraudulent maneuvers they are pulling...... Gordon Buffett 09/30/14 01:10:15 PM
#17701   WITH ALL THE POTATOES FROM PEI$$$$$$$$$$$ Angel21stCentury 09/29/14 09:26:02 PM
#17700   and how will all this be paid? Kalinn 09/29/14 09:19:31 PM
#17699   WHERE IS THE NEWS$$$$$$$$$$$$$$$ Angel21stCentury 09/29/14 08:15:04 PM
#17698   This just gives SS and CS to pocket Gordon Buffett 09/29/14 02:34:46 PM
#17697   CHEAP CHEAP CHEAP CHEAP CHEAP CHEAP! That's Gordon Buffett 09/29/14 02:32:30 PM
#17696   Give me all your burnt potatoes! I'll Gordon Buffett 09/29/14 02:30:07 PM
#17691   WE ALL HEARD THIS BEFORE,ITS ALL POTATOES FROM PEI Angel21stCentury 09/29/14 10:18:36 AM
#17690   This will be big. Patience everyone. A contract research rabbip 09/29/14 05:08:51 AM
#17688   DR.STEVE SLILATY HAS THE KEY TO THE POTATOE Angel21stCentury 09/28/14 07:12:21 PM
#17687   PhaseI It will never happen Ceo turd slilaty Cash Monster 09/28/14 06:29:51 PM
#17686   He has the key to his new m6 Cash Monster 09/28/14 06:18:34 PM
#17685   They has the key vs cancer... time to TraderUsa 09/28/14 06:13:51 PM
#17684   He is waiting your cheaps shares... You don't TraderUsa 09/28/14 06:12:55 PM
#17683   Experts like turd Slilaty bankrupting companies strait to Cash Monster 09/28/14 06:12:34 PM
#17682   With news about initiation phase I, SBFM = TraderUsa 09/28/14 06:10:00 PM
#17681   CRO's is most that Garmen... They are experts... TraderUsa 09/28/14 06:09:30 PM
#17680   Turd slilaty is a scam hoax. Hell is Cash Monster 09/28/14 06:01:24 PM
#17679   Where did you get this Cro from, it's Cash Monster 09/28/14 05:56:13 PM
#17678   FYI this is CRO's, fast pase I experts TraderUsa 09/28/14 05:49:19 PM
#17677   sbfm has a great future in the toilet Cash Monster 09/28/14 05:45:12 PM
#17676   Everyone in canada knows trueblue technology was Cash Monster 09/28/14 05:41:37 PM
#17675   Don't forget to mention 2.4 million dollars of Cash Monster 09/28/14 05:30:13 PM
#17674   Where did you parachute in from? this stock Kalinn 09/28/14 03:24:43 PM
#17673   That turd is bankrupt, the turd slilaty never Cash Monster 09/28/14 01:05:58 PM
#17672   FYI Genomic One and Trueblue Technologies is True TraderUsa 09/28/14 08:57:27 AM
#17671   Slilaty reputation has been burned in Canada after Cash Monster 09/27/14 08:19:00 PM