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Sunshine Biopharma Inc. (SBFM)

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Last Post: 8/29/2014 12:13:45 AM - Followers: 171 - Board type: Free - Posts Today: 2




"The Future Of Medicine"

Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options



Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.

Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug


Dec 10, 2012 Sunshine Biopharma Completes Another IND-Enabling Study: Adva-27a Is Found to Be Effective Against Multidrug Resistant Uterine Cancer Cells
Dec 5, 2012 Daily Watchlist: Sunshine Biopharma Inc. (OTCBB: SBFM), Biostar Pharmaceuticals, Inc. (NASDAQ: BSPM), Axia Group's (PINKSHEETS: AGIJ), Terralene Fuels Corporation (OTCQB: GSPT)
Dec 4, 2012 Sunshine Biopharma Completes Six IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Nov 27, 2012 Advanomics Corporation, the Parent Company of Sunshine Biopharma, Completes Acquisition of Adva-27a Patents
Nov 25, 2012 Volume Alerts: Medizone International (OTCQB: MZEI), SportsQuest, Inc. (PINKSHEETS: SPQS), Sunshine Biopharma Inc. (OTCBB: SBFM), Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH)
Nov 13, 2012 Sunshine Biopharma Initiates IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Oct 9, 2012 Sunshine Biopharma Receives Scale-Up Manufacturing Protocol for Its Lead Anti-Cancer Compound, Adva-27a
Sept 25, 2012 Les résultats des recherches précliniques sur l'Adva-27a de Sunshine Biopharma, seront publiés dans l'édition d'octobre d'ANTICANCER RESEARCH
Sept 25, 2012 Sunshine Biopharma's Adva-27a Preclinical Research Results to Be Published in October Issue of ANTICANCER RESEARCH
Sept 20, 2012 Breast Cancer News: Geron Drug Fails, Herceptin® May Increase Heart Problems, Sunshine Biopharma Heading for Clinical Trials

11/16/11 Sunshine Biopharma announces successful completion of preclinical studies for Adva-27a, the company's lead anti-cancer compound

10/5/11 Sunshine Biopharma's anti-cancer compound, Adva-27a, found to be a strong Topoisomerase II inhibitor

8/30/11 Clearance of Sunshine Biopharma's anti-cancer compound, Adva-27a, does not involve a toxic intermediate

8/10/11  Sunshine Biopharma Aims to Follow in Herceptin's Footsteps

8/2/11  Sunshine Biopharma Looking to Mimic Roche's Billion Dollar Cancer Drug Success

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals


SBFM Share Structure


Outstanding 51,391,092 a/o Nov 07, 2012
Float 13,916,529 a/o Mar 15, 2012
Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Tel: 514-764-9698
Fax: 514-764-9699




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Current Price
Bid Ask Day's Range
SBFM News: Quarterly Report (10-q) 08/12/2014 05:26:36 PM
SBFM News: Prospectus Filed Pursuant to Rule 424(b)(3) (424b3) 07/28/2014 04:05:06 PM
SBFM News: Notice of Effectiveness (effect) 07/24/2014 06:01:50 AM
SBFM News: Securities Registration Statement (s-1/a) 07/03/2014 06:02:21 AM
SBFM News: Sunshine Biopharma's Adva-27a Featured in 2014 Worldwide Uterine Cancer Report for Its Effectiveness Against Multidrug Resist... 06/09/2014 08:00:00 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#10706  Sticky Note SUNSHINE BIOPHARMA INC (quick info) BooDog 09/12/13 07:25:24 AM
#17382   This company has nothing, it's a hoax Cash Monster 08/29/14 12:13:45 AM
#17381   Turdmaster slilaty is running this strait to the Cash Monster 08/29/14 12:00:03 AM
#17380   The share price dipped to $0.08 today. $0.05 null 08/28/14 11:20:41 PM
#17379   TAKE OUT THE IND!!!!!! Angel21stCentury 08/28/14 08:02:59 PM
#17378   HOLD ON TO YOUR UNDERWEARS FOLKS,NEWS IS HOT Angel21stCentury 08/28/14 07:41:19 PM
#17376   What generic substances?? How many employees did this Cash Monster 08/28/14 08:59:35 AM
#17375   A recent announcement just went out discussing Sunshine Doc_John 08/27/14 10:38:53 AM
#17374   THE BOTTOM LINE IS ALL POTATOES$$$$$$$$$$$$$$$ Angel21stCentury 08/26/14 02:34:56 PM
#17373   THAT IS WHY STEVE SLILATY NEVER HELD A Angel21stCentury 08/26/14 01:45:20 PM
#17372   After 5 years of anti cancer drug developments Cash Monster 08/26/14 12:41:48 PM
#17371   This ticker symbol never made a penny in Cash Monster 08/26/14 12:33:43 PM
#17370   If slilaty the turd had a real anti Cash Monster 08/26/14 12:26:08 PM
#17369   Obviously doc ! However, please clarify a few reginaliberta 08/26/14 08:24:48 AM
#17366   It will never happen, slilaty the turd never Cash Monster 08/25/14 03:49:05 PM
#17365   If the turd slilaty had a billion dollar Cash Monster 08/25/14 03:27:15 PM
#17364   This is a company that obviously needs to Doc_John 08/25/14 02:52:34 PM
#17363   DR.STEVE SLILATY WILL BE ON FRONT PAGE OF Angel21stCentury 08/25/14 01:23:53 PM
#17362   WE WANT NEWS WITH MEAT ON IT$$$$$$$$$$$ Angel21stCentury 08/25/14 01:19:37 PM
#17361   FDA APPROVAL WILL TAKE PLACE ON CNN POWERED Angel21stCentury 08/25/14 01:18:02 PM
#17360   So I still believe the timing to be pijoe 08/25/14 12:37:15 PM
#17359   WATCH OUT,HERE COMES DR.STEVE SLILATY ON CNN INTERNATIONAL$$$$$$$$$$$$ Angel21stCentury 08/25/14 10:49:15 AM
#17358   Lol lol the party is in the toilet bowl Cash Monster 08/23/14 11:54:35 PM
#17357   BIG GALA ON THE WAY$$$$SHAREHOLDERS APPLAUD$$$$$$$$ Angel21stCentury 08/23/14 04:06:39 PM
#17356   TAKE OUT THE CHAMPAGNE,ITS TIME FOR SHOWERS$$$$$$$$$$ Angel21stCentury 08/23/14 12:46:00 AM
#17355   Patate Di Natalie reginaliberta 08/22/14 11:30:08 PM
#17354   NEXT NEWS THE SKY THE LIMIT FOLKS$$$$$$$$$$$$ Angel21stCentury 08/22/14 11:24:08 PM
#17353   WATCH OUT REGINAL,DR.SLILATY IS GOING FULL BLITZ NATION Angel21stCentury 08/22/14 11:22:00 PM
#17352   Gonna read my Ten Commandments to this ticker reginaliberta 08/22/14 04:42:44 PM
#17351   Wow big volume on news. Never fails reginaliberta 08/22/14 04:41:48 PM
#17350   SOUND ALL ALARMS,HERE WE GOOOOOOOOO$$$$$$$$$$ Angel21stCentury 08/22/14 02:11:42 PM
#17349   BIG PROMO ON THE WAY$$$$$$$$$$THE TIME HAS COME$$$$$$$$$$$$$$ Angel21stCentury 08/22/14 01:24:57 PM
#17348   GET READY FOR NEXT WEEK FOLKS, A BIG Angel21stCentury 08/22/14 01:20:43 PM
#17347   HOLD ON COWBOY,WE ARE GOING TO THE MOON$$$$$$$$$$$ Angel21stCentury 08/22/14 11:56:26 AM
#17346   Thought you were replying to my post on BooDog 08/22/14 11:53:48 AM
#17345   GET READY ITS ABOUT TO BLOW$$$$$$$$ Angel21stCentury 08/22/14 11:52:14 AM
#17344   THE BULLS ARE ON THE WAY$$$$$$$$$$$ Angel21stCentury 08/22/14 11:49:46 AM
#17343   IT WILL BE ON CNN INTERNATIONAL$$$$$$$$$$$$$$ Angel21stCentury 08/22/14 11:39:55 AM
#17342   THIS ONE CAME OUT YESTERDAY$$$$$$ Angel21stCentury 08/22/14 11:38:40 AM
#17341   What news are you talking about??? This turd Cash Monster 08/22/14 11:24:45 AM
#17340   Don't forget to flush down the toilet when Cash Monster 08/22/14 11:19:52 AM
#17339   It's in the toilet bowl with the rest Cash Monster 08/22/14 11:12:40 AM
#17338   Where is the volume? reginaliberta 08/22/14 10:53:22 AM
#17337   WE ARE GOLDEN HERE$$$$$$$WATCH THIS BABY TAKE OFF Angel21stCentury 08/22/14 06:08:06 AM
#17336   CHEAPIES ARE NOW ONLY A DREAM,RAISE UP THE Angel21stCentury 08/22/14 05:53:19 AM
#17335   WATCH OUT,THIS BABY IS GOING TO ROAR ONE Angel21stCentury 08/22/14 05:47:48 AM
#17334   Have some more cash standing by for SBFM. BooDog 08/22/14 05:19:19 AM
#17333   HE IS LAUNCHING ADVA-27A BREAST CANCER DRUG CLINICAL Angel21stCentury 08/21/14 08:22:23 PM
#17332   RELAX,HE IS COMING OUT BLAZING WITH NEWS ON Angel21stCentury 08/21/14 08:20:50 PM
#17331   STEVE SLILATY HAS THE BIGGEST BREAKTHROUGH IN THE Angel21stCentury 08/21/14 08:09:16 PM