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Sunshine Biopharma Inc. (SBFM)

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Last Post: 9/19/2014 3:15:09 PM - Followers: 172 - Board type: Free - Posts Today: 0




"The Future Of Medicine"

Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options



Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.

Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug


Dec 10, 2012 Sunshine Biopharma Completes Another IND-Enabling Study: Adva-27a Is Found to Be Effective Against Multidrug Resistant Uterine Cancer Cells
Dec 5, 2012 Daily Watchlist: Sunshine Biopharma Inc. (OTCBB: SBFM), Biostar Pharmaceuticals, Inc. (NASDAQ: BSPM), Axia Group's (PINKSHEETS: AGIJ), Terralene Fuels Corporation (OTCQB: GSPT)
Dec 4, 2012 Sunshine Biopharma Completes Six IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Nov 27, 2012 Advanomics Corporation, the Parent Company of Sunshine Biopharma, Completes Acquisition of Adva-27a Patents
Nov 25, 2012 Volume Alerts: Medizone International (OTCQB: MZEI), SportsQuest, Inc. (PINKSHEETS: SPQS), Sunshine Biopharma Inc. (OTCBB: SBFM), Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH)
Nov 13, 2012 Sunshine Biopharma Initiates IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Oct 9, 2012 Sunshine Biopharma Receives Scale-Up Manufacturing Protocol for Its Lead Anti-Cancer Compound, Adva-27a
Sept 25, 2012 Les résultats des recherches précliniques sur l'Adva-27a de Sunshine Biopharma, seront publiés dans l'édition d'octobre d'ANTICANCER RESEARCH
Sept 25, 2012 Sunshine Biopharma's Adva-27a Preclinical Research Results to Be Published in October Issue of ANTICANCER RESEARCH
Sept 20, 2012 Breast Cancer News: Geron Drug Fails, Herceptin® May Increase Heart Problems, Sunshine Biopharma Heading for Clinical Trials

11/16/11 Sunshine Biopharma announces successful completion of preclinical studies for Adva-27a, the company's lead anti-cancer compound

10/5/11 Sunshine Biopharma's anti-cancer compound, Adva-27a, found to be a strong Topoisomerase II inhibitor

8/30/11 Clearance of Sunshine Biopharma's anti-cancer compound, Adva-27a, does not involve a toxic intermediate

8/10/11  Sunshine Biopharma Aims to Follow in Herceptin's Footsteps

8/2/11  Sunshine Biopharma Looking to Mimic Roche's Billion Dollar Cancer Drug Success

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals


SBFM Share Structure


Outstanding 51,391,092 a/o Nov 07, 2012
Float 13,916,529 a/o Mar 15, 2012
Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Tel: 514-764-9698
Fax: 514-764-9699




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SBFM News: Quarterly Report (10-q) 08/12/2014 05:26:36 PM
SBFM News: Prospectus Filed Pursuant to Rule 424(b)(3) (424b3) 07/28/2014 04:05:06 PM
SBFM News: Notice of Effectiveness (effect) 07/24/2014 06:01:50 AM
SBFM News: Securities Registration Statement (s-1/a) 07/03/2014 06:02:21 AM
SBFM News: Sunshine Biopharma's Adva-27a Featured in 2014 Worldwide Uterine Cancer Report for Its Effectiveness Against Multidrug Resist... 06/09/2014 08:00:00 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#10706  Sticky Note SUNSHINE BIOPHARMA INC (quick info) BooDog 09/12/13 07:25:24 AM
#17606   downtrend? lol Kalinn 09/19/14 03:15:09 PM
#17605   dead money Kalinn 09/19/14 03:12:19 PM
#17604   "SUNSHINE BIOPHARMA'S MIRACLE CANCER DRUG ADVA-27A MUST SHINE Angel21stCentury 09/19/14 01:44:31 PM
#17603   ALL GEARING UP FOR AN INTERNATIONAL BREAKTHROUGH$$$$$$$$$$$$$ Angel21stCentury 09/19/14 01:41:58 PM
#17602   Where is everyone? Gordon Buffett 09/19/14 11:40:31 AM
#17601   Where the heck is all of this dumping reportmyabuse 09/16/14 03:20:39 PM
#17600   WHO IS CRO FOR THIS GARBAGE CAN FULL Angel21stCentury 09/16/14 10:16:22 AM
#17599   Agree Citrati. I've been taking advantage. BooDog 09/16/14 05:49:01 AM
#17598   VOLCANO WILL ERRUPT$$$$$$$$$$$$$$$$ Angel21stCentury 09/15/14 11:01:55 PM
#17597   WATCH OUT,DR.STEVE SLILATY HAS TKO NEWS ON ALL WIRES$$$$$$$$$ Angel21stCentury 09/15/14 11:01:11 PM
#17596   You also lost it all with this scam? Cash Monster 09/15/14 05:03:11 PM
#17595   Lights out people, SBFM is bankrupt Cash Monster 09/15/14 05:01:32 PM
#17594   He has no news, he has nothing, jail Cash Monster 09/15/14 04:59:48 PM
#17593   It's great science when Ceo is driving a Cash Monster 09/15/14 04:57:36 PM
#17592   Nice mazo, thank god you didn't invest in Cash Monster 09/15/14 04:49:18 PM
#17591   There is no value here,turd Ceo scammed investors Cash Monster 09/15/14 04:46:31 PM
#17590   What do you expect,Ceo is a hoax,a brought Cash Monster 09/15/14 04:42:22 PM
#17589   Must have been sheer luck. Citrati 09/15/14 04:33:48 PM
#17588   dead money Kalinn 09/15/14 04:08:21 PM
#17587   WHERE IS THE NEWS ON IND OF DR.SLILATY'S POTATOES$$$$$ Angel21stCentury 09/15/14 12:52:04 PM
#17586   WHAT ABOUT THIS DIRTY FAT GARBAGE CAN CALLED SBFM Angel21stCentury 09/15/14 12:47:41 PM
#17585   Forget that..just made a bundle on ALKM.. Wahooooooooooooooooo mazo 09/15/14 12:29:24 PM
#17584   mazo, set your sights on PVSP. :-) BooDog 09/15/14 10:10:34 AM
#17583   Cheap, cheap, cheap......its not just for the birds. Gordon Buffett 09/15/14 10:05:54 AM
#17579   FAT LADY HAS SUNG FOR SBFM..CHART SHOWS STEADY mazo 09/14/14 04:55:39 PM
#17577   Good one. This is so far off BooDog 09/13/14 09:17:27 PM
#17576   WATCH OUT NEWS ON IND WILL SEND THIS Angel21stCentury 09/13/14 06:57:21 PM
#17575   AMERICANBULLS = STAY OUT.. GOING TO TRIPS.. BUYER mazo 09/13/14 05:14:03 PM
#17574   BUCKLE UP MAZO THRUSTERS ALL ACTIVATED$$$$$$ Angel21stCentury 09/13/14 12:58:46 PM
#17571   Bring it on mazo. btw, not a BooDog 09/12/14 06:44:19 PM
#17570   BARCHARTS = 100% SELL .. FLUFF PR'S..ANOTHER PINKY mazo 09/12/14 05:41:09 PM
#17565   THE PARTY HAS JUST BEGUN$$$$$A BREAKTHROUGH IS ON Angel21stCentury 09/11/14 04:37:17 PM
#17561   It's just good science bro. reportmyabuse 09/11/14 02:00:44 PM
#17560   Little bites turn into big bites ! Gordon Buffett 09/11/14 01:46:47 PM
#17559   Here we go! CHOMP ! Gordon Buffett 09/11/14 10:47:55 AM
#17558   YOU BETTER HOLD ON TO YOUR UNDERWEARS,HOLY GRAIL Angel21stCentury 09/10/14 10:14:55 PM
#17557   WELCOME ABOARD,HOLD ON TIGHT WE ARE GOING TO Angel21stCentury 09/10/14 10:04:15 PM
#17556   Just as long as there is one mark ctrumabll 09/10/14 09:24:38 PM
#17555   How long will they shake this turd for??? Cash Monster 09/10/14 08:24:44 PM
#17554   Turdmaster Slilaty is a coward, hides from all Cash Monster 09/10/14 08:04:29 PM
#17553   Realized this down tick in the stock is ctrumabll 09/10/14 07:55:00 PM
#17552   No one wants this turd,Watch this turd hit Cash Monster 09/10/14 07:52:13 PM
#17551   Turd,hoax,scam Slilaty got his pockets full with investors$$$$ Cash Monster 09/10/14 07:45:33 PM
#17550   Alright, I've had a moment to calm down. reportmyabuse 09/10/14 07:01:44 PM
#17549   Mayday! Mayday! Please save us Jebus! reportmyabuse 09/10/14 06:59:44 PM
#17548   fives years of nothingness, no peer recognition anywhere Kalinn 09/10/14 04:27:37 PM
#17547   He is quite popular here! Gordon Buffett 09/10/14 04:21:55 PM
#17546   tell that to Camille Kalinn 09/10/14 04:10:50 PM
#17545   ...and "initiating", "commencing" and "beginning" mean the same thing. Gordon Buffett 09/10/14 04:07:45 PM