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Sunshine Biopharma Inc. (SBFM)

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Last Post: 9/2/2014 2:52:53 PM - Followers: 171 - Board type: Free - Posts Today: 13








 



 

 


"The Future Of Medicine"





Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 






Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 
 


Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697








Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.


Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options




 










 

Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).




The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.
 






Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug







 




OTCBB NEWS link http://www.otcbb.com/asp/Info_Center.asp
Dec 10, 2012 Sunshine Biopharma Completes Another IND-Enabling Study: Adva-27a Is Found to Be Effective Against Multidrug Resistant Uterine Cancer Cells
Dec 5, 2012 PennyTrackers.com Daily Watchlist: Sunshine Biopharma Inc. (OTCBB: SBFM), Biostar Pharmaceuticals, Inc. (NASDAQ: BSPM), Axia Group's (PINKSHEETS: AGIJ), Terralene Fuels Corporation (OTCQB: GSPT)
Dec 4, 2012 Sunshine Biopharma Completes Six IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Nov 27, 2012 Advanomics Corporation, the Parent Company of Sunshine Biopharma, Completes Acquisition of Adva-27a Patents
Nov 25, 2012 Insidebulls.com Volume Alerts: Medizone International (OTCQB: MZEI), SportsQuest, Inc. (PINKSHEETS: SPQS), Sunshine Biopharma Inc. (OTCBB: SBFM), Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH)
Nov 13, 2012 Sunshine Biopharma Initiates IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Oct 9, 2012 Sunshine Biopharma Receives Scale-Up Manufacturing Protocol for Its Lead Anti-Cancer Compound, Adva-27a
Sept 25, 2012 Les résultats des recherches précliniques sur l'Adva-27a de Sunshine Biopharma, seront publiés dans l'édition d'octobre d'ANTICANCER RESEARCH
Sept 25, 2012 Sunshine Biopharma's Adva-27a Preclinical Research Results to Be Published in October Issue of ANTICANCER RESEARCH
Sept 20, 2012 Breast Cancer News: Geron Drug Fails, Herceptin® May Increase Heart Problems, Sunshine Biopharma Heading for Clinical Trials

11/16/11 Sunshine Biopharma announces successful completion of preclinical studies for Adva-27a, the company's lead anti-cancer compound

10/5/11 Sunshine Biopharma's anti-cancer compound, Adva-27a, found to be a strong Topoisomerase II inhibitor

8/30/11 Clearance of Sunshine Biopharma's anti-cancer compound, Adva-27a, does not involve a toxic intermediate

8/10/11  Sunshine Biopharma Aims to Follow in Herceptin's Footsteps

8/2/11  Sunshine Biopharma Looking to Mimic Roche's Billion Dollar Cancer Drug Success





SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals


 







SBFM Share Structure

From otcmarkets.com

Outstanding 51,391,092 a/o Nov 07, 2012
Float 13,916,529 a/o Mar 15, 2012
Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO




SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

http://corporatestock.com




Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Canada
Tel: 514-764-9698
Fax: 514-764-9699

http://sunshinebiopharma.com
info@sunshinebiopharma.com


 






 

 












































































 
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Wiki
SBFM News: Quarterly Report (10-q) 08/12/2014 05:26:36 PM
SBFM News: Prospectus Filed Pursuant to Rule 424(b)(3) (424b3) 07/28/2014 04:05:06 PM
SBFM News: Notice of Effectiveness (effect) 07/24/2014 06:01:50 AM
SBFM News: Securities Registration Statement (s-1/a) 07/03/2014 06:02:21 AM
SBFM News: Sunshine Biopharma's Adva-27a Featured in 2014 Worldwide Uterine Cancer Report for Its Effectiveness Against Multidrug Resist... 06/09/2014 08:00:00 AM
PostSubject
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#10706  Sticky Note SUNSHINE BIOPHARMA INC (quick info) BooDog 09/12/13 07:25:24 AM
#17429   WHERE IS YOUR BUY ORDER RABBIP,BUY NOW YOU Angel21stCentury 09/02/14 02:52:53 PM
#17428   slilaty the turdmaster scam hoax has pulled the Cash Monster 09/02/14 12:56:05 PM
#17427   Garmen labs is bankrupt,just called advanomics phone service Cash Monster 09/02/14 12:52:56 PM
#17426   SO THEN CALL CAMILLE SEBAALY CFO,IR INFORMATION,PROMOTIONS AND Angel21stCentury 09/02/14 12:00:30 PM
#17425   Have fun, no one is there, everything is Cash Monster 09/02/14 11:42:04 AM
#17424   What are you waiting for to buy these Cash Monster 09/02/14 11:29:25 AM
#17423   I might have to go take a look Gordon Buffett 09/02/14 11:26:56 AM
#17422   Thanks Boodog, I saw the vwap deal, looks Gordon Buffett 09/02/14 11:24:58 AM
#17421   ATTN:ATTN SBFM BOARD MR BUFFETT IS IN THE HOUSE$$$$$$$$$$$$$$ Angel21stCentury 09/02/14 08:52:05 AM
#17420   NEWS IS HOT ON ALL WIRES CNN INTERNATIONAL$$$$$$$ Angel21stCentury 09/02/14 08:06:49 AM
#17419   DONT WASTE ANY TIME,EAT UP THE ASK TILL Angel21stCentury 09/02/14 08:03:11 AM
#17418   Going through a phase of dilution for financing BooDog 09/02/14 06:13:57 AM
#17417   Hey, let me make this short and sweet Cash Monster 09/02/14 12:17:44 AM
#17416   I hope you're right Angel21. But I'm Gordon Buffett 09/01/14 11:31:07 PM
#17415   MR.BUFFETT DR.STEVE SLILATY'S ADVA-27A IS THE MOST EFFECTIVE Angel21stCentury 09/01/14 08:29:16 PM
#17414   BUY,BUY,BUY Mr.BUFFETT BEFORE THIS POPS TO DOLLAR LAND$$$$$$$$$ Angel21stCentury 09/01/14 06:06:38 PM
#17413   WELCOME MR.BUFFETT NICE TO HAVE YOU ABOARD SBFM,YOU Angel21stCentury 09/01/14 01:53:08 PM
#17412   Looking for some fundamental info on SBFM. Gordon Buffett 09/01/14 11:00:14 AM
#17411   Watch this turd gem come strait down to Cash Monster 08/31/14 08:38:11 PM
#17410   THERE IS NOTHING TO BASH,DR.STEVE SLILATY HAS ACCOMPLISHED Angel21stCentury 08/31/14 06:09:29 PM
#17409   You are bashers forcing the price down to rabbip 08/31/14 01:55:20 PM
#17408   THAT IS WHY DR.STEVE SLILATY HIDES LIKE A Angel21stCentury 08/31/14 09:18:24 AM
#17407   Turdmaster slilaty funnelled over 2million of investors money Cash Monster 08/30/14 10:52:46 PM
#17406   That is because slilaty is a hoax scam. Cash Monster 08/30/14 10:33:58 PM
#17405   ronpopeil, Your handle seems familiar. Did our paths cross null 08/30/14 09:23:38 PM
#17404   SBFM is simply a turd that will get Cash Monster 08/30/14 07:52:04 PM
#17403   You can take them news and flush them Cash Monster 08/30/14 07:47:04 PM
#17401   YES,THEY ARE ALL MADE FOR THE GARBAGE BIN,COULD,WOULD,SHOULD Angel21stCentury 08/30/14 12:43:58 PM
#17400   But you have to love his press releases. ronpopeil 08/30/14 11:26:17 AM
#17399   DR.STEVE SLILATY IS ALL ABOUT BURNT POTATOES AND Angel21stCentury 08/30/14 10:55:04 AM
#17398   You have to wonder if they ever engaged ronpopeil 08/30/14 10:14:01 AM
#17397   Whoever dumped all those shares is a real Cash Monster 08/29/14 08:37:48 PM
#17396   No trades today goes to show someone needed Doc_John 08/29/14 05:48:57 PM
#17395   NO MANUFACTURING,NO PRODUCTION,NO ANIMAL STUDIES,NO IND,NO CLINICAL TRIALS,NO Angel21stCentury 08/29/14 12:33:26 PM
#17394   GARMEN IS BANKRUPT!!!! Angel21stCentury 08/29/14 12:16:55 PM
#17393   lmao, sure hope not!!! Thinking this Fall BooDog 08/29/14 11:43:04 AM
#17392   So are you telling me that we have null 08/29/14 11:38:07 AM
#17391   one of the machines there hit after being BooDog 08/29/14 11:24:41 AM
#17390   You may very well get your wishing price. null 08/29/14 11:20:19 AM
#17389   TAKE OUT THE NEWS$$$$WE ARE ALL FED UP Angel21stCentury 08/29/14 10:24:06 AM
#17388   THATS ALL POTATOES,WE LOVE YOU BIOMANBABA,THIS GARBAGE CAN Angel21stCentury 08/29/14 10:18:22 AM
#17387   it's gambling $$$ to me but a gtc BooDog 08/29/14 10:00:41 AM
#17386   IMMB has successfully completed phase 1, 2 and sweeptoronto 08/29/14 09:57:02 AM
#17385   CALL CAMILLE SEBAALY CFO 1-514-814-0464 HE LIED TO ALL..... Angel21stCentury 08/29/14 09:21:08 AM
#17384   COULD,WOULD,SHOULD DR.STEVE SLILATY MAGICAL SPEECH ALL HIS CAREER Angel21stCentury 08/29/14 08:57:33 AM
#17383   Yes poor corporate governance, no direction,no goals no carpetdude 08/29/14 08:42:07 AM
#17382   This company has nothing, it's a hoax Cash Monster 08/29/14 12:13:45 AM
#17381   Turdmaster slilaty is running this strait to the Cash Monster 08/29/14 12:00:03 AM
#17380   The share price dipped to $0.08 today. $0.05 null 08/28/14 11:20:41 PM
#17379   TAKE OUT THE IND!!!!!! Angel21stCentury 08/28/14 08:02:59 PM
PostSubject