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Sunshine Biopharma Inc. (SBFM)

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Last Post: 10/30/2014 10:42:05 PM - Followers: 171 - Board type: Free - Posts Today: 0








 



 

 


"The Future Of Medicine"
 

 




 
Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 





 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 
 


Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697




 



Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.


Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options




 





 

 



 

 
 
Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).




The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.
 






Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug







 




OTCBB NEWS link http://www.otcbb.com/asp/Info_Center.asp
Dec 10, 2012 Sunshine Biopharma Completes Another IND-Enabling Study: Adva-27a Is Found to Be Effective Against Multidrug Resistant Uterine Cancer Cells
Dec 5, 2012 PennyTrackers.com Daily Watchlist: Sunshine Biopharma Inc. (OTCBB: SBFM), Biostar Pharmaceuticals, Inc. (NASDAQ: BSPM), Axia Group's (PINKSHEETS: AGIJ), Terralene Fuels Corporation (OTCQB: GSPT)
Dec 4, 2012 Sunshine Biopharma Completes Six IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Nov 27, 2012 Advanomics Corporation, the Parent Company of Sunshine Biopharma, Completes Acquisition of Adva-27a Patents
Nov 25, 2012 Insidebulls.com Volume Alerts: Medizone International (OTCQB: MZEI), SportsQuest, Inc. (PINKSHEETS: SPQS), Sunshine Biopharma Inc. (OTCBB: SBFM), Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH)
Nov 13, 2012 Sunshine Biopharma Initiates IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Oct 9, 2012 Sunshine Biopharma Receives Scale-Up Manufacturing Protocol for Its Lead Anti-Cancer Compound, Adva-27a
Sept 25, 2012 Les résultats des recherches précliniques sur l'Adva-27a de Sunshine Biopharma, seront publiés dans l'édition d'octobre d'ANTICANCER RESEARCH
Sept 25, 2012 Sunshine Biopharma's Adva-27a Preclinical Research Results to Be Published in October Issue of ANTICANCER RESEARCH
Sept 20, 2012 Breast Cancer News: Geron Drug Fails, Herceptin® May Increase Heart Problems, Sunshine Biopharma Heading for Clinical Trials
 

11/16/11 Sunshine Biopharma announces successful completion of preclinical studies for Adva-27a, the company's lead anti-cancer compound

10/5/11 Sunshine Biopharma's anti-cancer compound, Adva-27a, found to be a strong Topoisomerase II inhibitor

8/30/11 Clearance of Sunshine Biopharma's anti-cancer compound, Adva-27a, does not involve a toxic intermediate

8/10/11  Sunshine Biopharma Aims to Follow in Herceptin's Footsteps

8/2/11  Sunshine Biopharma Looking to Mimic Roche's Billion Dollar Cancer Drug Success





SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals
 
 

 
We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.

 
Intellectual Property

 
We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
 
 
Advanomics

http://www.canada-companies-info.com/advanomics-corporationcorporation-advanomics-65q2
Advanomics Corporation, the Parent Company of Sunshine Biopharma
 

Head Office:

Advanomics Corporation

2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Canada

Tel: 514-764-9698
Fax: 514-764-9699
info@advanomics.com


For specific information, please contact:

Mr. Camille Sebaaly
Tel: 514-814-0464
Fax: 450-689-6397
camille.sebaaly@advanomics.com


Product Pipeline

Our product pipeline is comprised of the following anti-tumor compounds:

Adva-27a

Difluoro-Etoposide™
Entering Phase I later this year (Lead Compound)

 

Adva-R46

RNAi Anti-Cancer drug candidate
Soon to enter animal studies phase

 

Adva-33c

Difluoro-Carboplatin™
Currently in preclinical phase



 







SBFM Share Structure
 

From otcmarkets.com and SEC filings
The number of shares of the registrant’s only class of common stock issued and outstanding as of August 12, 2014, was 68,270,961 shares.
 

Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO




SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

http://corporatestock.com




Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Canada
Tel: 514-764-9698
Fax: 514-764-9699

http://sunshinebiopharma.com
info@sunshinebiopharma.com


 

 



 


 

 












































































 
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Wiki
SBFM News: Quarterly Report (10-q) 08/12/2014 05:26:36 PM
SBFM News: Prospectus Filed Pursuant to Rule 424(b)(3) (424b3) 07/28/2014 04:05:06 PM
SBFM News: Notice of Effectiveness (effect) 07/24/2014 06:01:50 AM
SBFM News: Securities Registration Statement (s-1/a) 07/03/2014 06:02:21 AM
SBFM News: Sunshine Biopharma's Adva-27a Featured in 2014 Worldwide Uterine Cancer Report for Its Effectiveness Against Multidrug Resist... 06/09/2014 08:00:00 AM
PostSubject
#17847  Sticky Note SUNSHINE BIOPHARMA INC (quick info) BooDog 10/07/14 07:08:41 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#18138   Boy ohhh boy,just got another pm camille sold ThunderStriker 10/30/14 10:42:05 PM
#18136   On cherche camille pour tout l'argent q'il a lesmotards 10/30/14 09:29:46 PM
#18135   When all was said done, this drug was Jimmythegreek 10/30/14 08:14:01 PM
#18134   my partner invested 200 000 in private placement Jimmythegreek 10/30/14 08:04:57 PM
#18133   TAKE OUT THE NEWS DR.STEVE SLILATY THE CURE Angel21stCentury 10/30/14 06:58:09 PM
#18132   WHERE IS THE CURE TO BREAST CANCER ON Angel21stCentury 10/30/14 06:46:55 PM
#18131   Just got another pm and he states that ThunderStriker 10/30/14 05:55:19 PM
#18130   I told you,these turds deserve no respect for Cash Monster 10/30/14 05:40:29 PM
#18129   Just got pm, rathead camille also brought advanomics ThunderStriker 10/30/14 05:23:02 PM
#18128   Ceo the turd Slilaty will end up in Cash Monster 10/30/14 04:52:14 PM
#18127   Prettyboy president and rathead camille took investors to ThunderStriker 10/30/14 04:45:45 PM
#18126   ENOUGH IS ENOUGH......3 cent bid/ask spread on this Gordon Buffett 10/30/14 04:42:00 PM
#18125   As usual no answer, rathead is in deep ThunderStriker 10/30/14 04:35:46 PM
#18124   CALL THE DIRTY SCUMBAG SCAM CAMILLE SEBAALY CFO,1-514-814-0464 Angel21stCentury 10/30/14 04:23:41 PM
#18123   WHERE ARE YOU DOCJOHN YOU DIRTY PIECE OF Angel21stCentury 10/30/14 04:06:07 PM
#18122   THE WORLD KNOWS CFO THE SCAM CAMILLE SEBAALY Angel21stCentury 10/30/14 04:01:39 PM
#18121   Rathead camille, made people belive that funds where ThunderStriker 10/30/14 03:55:51 PM
#18120   The turd slilaty ran a billion dollar co. Cash Monster 10/30/14 03:49:33 PM
#18119   It's a scam hoax,turdmaster slilaty has nothing,funnelled everything Cash Monster 10/30/14 03:43:16 PM
#18118   Speculative gamble buy ~ around .05 - .06. BooDog 10/30/14 03:40:39 PM
#18117   BooDog... I haven't been watching this and don't KarinCA 10/30/14 03:32:25 PM
#18116   they will all pay dearly for this scam Cash Monster 10/30/14 03:03:49 PM
#18115   The rathead is not answering, just got a ThunderStriker 10/30/14 02:49:00 PM
#18114   EVERYBODY CALL CAMILLE SEBAALY CFO 514-814-0464 HE IS Angel21stCentury 10/30/14 02:40:37 PM
#18113   I will make sure everyone in montreal,laval,quebec knows Cash Monster 10/30/14 02:16:59 PM
#18112   WE WILL NOT FAULTER WE WILL NOT FAIL,TAKE Angel21stCentury 10/30/14 02:04:43 PM
#18111   THIS TRASH CAN BETTER WAKE UP AND FAST Angel21stCentury 10/30/14 01:54:38 PM
#18110   Prettyboy and rathead know very well where the ThunderStriker 10/30/14 01:31:45 PM
#18109   Don't forget to ask him what he did Cash Monster 10/30/14 01:02:44 PM
#18108   TAKE OUT THE CURE TO CANCER YOU DIRTY SCUMBAGS Angel21stCentury 10/30/14 12:59:18 PM
#18107   CALL CAMILLE SEBAALY CFO 1-514-814-0464 HE LIED TO EVERYBODY. Angel21stCentury 10/30/14 12:57:45 PM
#18106   Wow, looks like prettyboy is doing very well ThunderStriker 10/30/14 12:44:49 PM
#18105   New car m6 bmw convertible, New house. All Cash Monster 10/30/14 11:57:29 AM
#18104   Lmao, get used to it, slilaty is a Cash Monster 10/30/14 11:41:35 AM
#18103   It must be difficult being a mod for fraudsters. ThunderStriker 10/30/14 10:44:16 AM
#18102   Ebola.... these fraudsters dont even have a lab, ThunderStriker 10/30/14 10:38:42 AM
#18101   Ohhh lord have mercy, what the heck did ThunderStriker 10/30/14 10:18:52 AM
#18100   NO CRO,NO IND,NO ANIMAL STUDIES,NO MANUFACTURING,NO PRODUCTION,NO AQUISITION,NO Angel21stCentury 10/30/14 09:59:44 AM
#18099   Angel, prettyboy and rathead lied to everybody, an ThunderStriker 10/30/14 09:47:52 AM
#18098   WHERE IS THE CURE TO BREAST CANCER???CAMILLE BETTER Angel21stCentury 10/30/14 09:42:26 AM
#18097   BUFFETT STOP BUYING ALL THE CHEAPIES$$$ Angel21stCentury 10/30/14 09:36:52 AM
#18096   Rathead sure is hiding from everybody, called him ThunderStriker 10/30/14 08:02:05 AM
#18095   I cant believe this but looks like you ThunderStriker 10/30/14 07:50:48 AM
#18094   That is very true. Investors here are lost ThunderStriker 10/30/14 07:42:14 AM
#18093   one will go crazy looking at it every day! vip1999 10/30/14 01:08:22 AM
#18092   Welcome to bi-polar land, this board is ThunderStriker 10/29/14 08:03:58 PM
#18091   Now I understand why nobody is investing in this ThunderStriker 10/29/14 08:01:00 PM
#18090   What happen to the cure to cancer?? ThunderStriker 10/29/14 07:55:19 PM
#18089   HOW CAN YOU FORGET ABOUT THAT DIRTY TRASH Angel21stCentury 10/29/14 03:50:25 PM
#18088   ADVA-27A IS STILL IN THE PETRI-DISH,WHERE IS IND??? Angel21stCentury 10/29/14 03:39:49 PM
PostSubject