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Sunshine Biopharma Inc. (SBFM)

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Last Post: 6/24/2016 5:06:39 PM - Followers: 314 - Board type: Free - Posts Today: 8








 



 

 


"The Future Of Medicine"
 

 




 
Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 





 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 
 


Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

 

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.


Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options

 
 
Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.







Check out SBFM's drug Adva-27a (27a) vs the leading chem drug Etoposide (2) - results are better in every category except two. And in the multi drug resistance breast cancer category (MCF7R) it's over 3x more effective. 







 
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).


Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug




They have been changing the timeline for years Now “mid/late 2017” now to start phase 1. Anyone can review past quarterlies to see that it keeps on sliding to the right. Share structure will be raised to 3B as stated here http://www.sec.gov/Archives/edgar/data/1402328/000135448816006700/sbfm_10k.htm Yes, dilution is going nuts, and I sure wouldn’t mind the 35% discount. Pretty much the saga continues. Imo.

Just a few random excerpts. Mostly for my own notes.

1st Q 2016

Common Stock, $0.001 per share; Authorized 500,000,000 Shares; Issued and outstanding 232,876,353 and 198,265,118 at March 31, 2016 and December 31, 2015 respectively


Weighted Average Common Shares Outstanding
215,596,040 78,942,780

Note 1 – Descriptions of Business
In July 2014, the Company formed a wholly owned Canadian subsidiary, Sunshine Biopharma Canada Inc. (“Sunshine Canada”) for the purposes of conducting pharmaceutical business in Canada and elsewhere around the globe. Sunshine Canada is currently working on securing a Drug Establishment License from Health Canada and signing manufacturing, marketing, sales and distribution contracts for various generic pharmaceuticals for sale in Canada and overseas.

During the last three month period the Company has continued to raise money through stock sales and borrowings.

Note 4 – Notes Payable

A Note having a Face Value of $19,142 was entered into on December 31, 2015. This Note accrues interest at the rate of 12% per annum and a total of $574 in accrued interest was expensed during the quarter ended March 31, 2016. This is a Non-convertible Note due on December 31, 2016.

A Note having a principal balance of $83,000 as of December 31, 2015 was fully converted, together with $3,320 of accrued interest thereon, into $0.001 par value Common Stock during the three month period ended March 31, 2016. In connection therewith, 9,906,049 shares of $0.001 par value Common Stock valued at $146,658 were issued generating a loss of $63,658 on conversion.

A Note having a Face Value $203,036 with interest of 12% is due June 30, 2016. This Note is convertible after December 31, 2015 into $0.001 par value Common Stock at a price 35% below market value. During the period ended March 31, 2016, a total of $38,036 in principal was converted into $0.001 par value Common Stock leaving a principal balance of $165,000. In connection this conversion, 7,705,186 shares of $0.001 par value Common Stock valued at $231,156 were issued generating a loss of $193,120 on conversion.
On February 18, 2016, the Company received monies in exchange for a note due November 18, 2016 having a Face Value of $85,000 and accruing interest at 8%. The Note is convertible after 180 days from issuance into $0.001 par value Common Stock at a price 35% below market value.
Note 5 – Notes Payable Related Entity
On October 8, 2015, the Company acquired from Advanomics Corporation (a related party) U.S. Patent Number 8,236,935 (the “Patent”) for the anticancer compound, Adva-27a, which includes all rights to this intellectual property within the United States in exchange for an interest-free note payable for $4,320,000 with annual payments of $360,000 due and payable on or before December 31, commencing in 2016 and continuing until paid in full. The note is collateralized by the Patent. Pursuant to an amendment agreement effective December 28, 2015, this note was cancelled and replaced with a new note having a face value of $210,519, comprised of $155,940 in principal amount which is the seller’s (Advanomics Corporation, a related party) book value of the Patent plus $54,579 as an adjustment for the currency exchange difference, which was expensed immediately. This new, interest-free Note is automatically convertible into a fixed number of 80,968,965 shares of the Company’s $0.001 par value Common Stock upon the Company completing an increase in its authorized capital such that a sufficient number of Common shares is available for issuance. However, if the Company does not increase its capitalization within 90 days from the date of the Note, interest will begin to accrue at the rate of 10% per annum.

On December 28, 2015, the Company acquired from Advanomics Corporation (a related party) the worldwide issued and pending patents under PCT/FR2007/000697 and PCT/CA2014/000029 (the “Patents”) for the anticancer compound, Adva-27a, which include all worldwide rights to this intellectual property in exchange for a note payable for $12,822,499, with interest accruing at 2% per year beginning January 1, 2016 and quarterly payments of $70,000 plus interest commencing the end of March 2016 and continuing until December 2020 when the entire principal balance and all accrued interest will be due. The note is collateralized by the Patents. Pursuant to an amendment agreement, effective December 28, 2015, this note was cancelled and replaced with a new convertible note having a face value of $624,875, comprised of $462,870 in principal amount which is the seller’s (Advanomics Corporation, a related party) book value of the Patents, plus a $162,005 amount as an adjustment for the currency exchange difference, which was expensed immediately. This new, interest-free Note is automatically convertible into a fixed number of 240,336,451 shares of $0.001 par value Common Stock upon the Company completing an increase in its authorized capital such that a sufficient number of Common shares is available for issuance. However, if the Company does not increase its capitalization within 90 days from the date of the Note, interest will begin to accrue at the rate of 10% per annum.

Note 6 – Issuance of Common Stock

At March 31, 2016 the Company had issued and outstanding 232,876,353 shares of $0.001 par value Common Stock. During the three months ended March 31, 2016, the Company issued a total of 34,611,235 shares of $0.001 par value Common Stock. Of these, 17,611,235 shares having a market value of $377,814 have been issued reducing debt by $121,036 and interest payable by $3,120 and generating a loss on conversion of $253,658 for the period ended March 31, 2016. The Company issued 7,000,000 shares of $0.001 par value Common Stock for $105,000 Canadian (approximately $79,128 US). For services to be rendered, the Company issued 10,000,000 shares of $0.001 par value Common Stock having a market value of $100,000 or $0.01 per share, to an unaffiliated company that is assisting the Company in the development of manufacturing, marketing, sales and distribution contracts for various generic pharmaceuticals and biomedical products in Canada. These services are for a two year period and will be expensed ratably over a 24 month period commencing April 1, 2016.

Note 7 – Issuance of Series “B” Preferred Stock

During the year ended December 31, 2015, the Company authorized 500,000 shares of $0.10 par value Series “B” Preferred Stock. The Series “B” Preferred Stock is non-convertible, non-redeemable and non-retractable. It has superior liquidation rights to the Common Stock at $0.10 per share and gives the holder the right to 1,000 votes per share. All 500,000 shares of Series “B” Preferred Shares were issued to the CEO of the Company in exchange for services valued at $50,000.
Note 8 – Earnings (Loss) Per Share

Earnings (loss) per share is computed using the weighted average number of Common Shares outstanding during the period. The Company has adopted ASC 260 (formerly SFAS128), “Earnings per Share”. Other than the shares to be issued for the purchased patents as specified under Note 5 above, the Company has no potentially dilutive instruments outstanding.

Note 9 – Financial Statements

For a complete set of footnotes, reference is made to the Company’s Report on Form 10-K for the year ended December 31, 2015, as filed with the Securities and Exchange Commission and the audited financial statements included therein.


Note 10 – Income Taxes


Certain members of the Company’s management, including Dr. Steve N. Slilaty, our President, CEO and a Director and Camille Sebaaly, our CFO, Secretary and a Director, hold similar positions with Advanomics Corporation, the seller of the Adva-27a patents recently acquired by the Company (See Note 5 above).


The Company’s principal place of business is located at 469 Jean-Talon West, 3rd Floor, Montreal, Quebec, Canada, H3N 1R4. This is also the location of Advanomics, who continues to provide this space to the Company on a rent free basis as of the date of this Report. Dr. Steve N. Slilaty, the Company’s Chief Executive Officer and a Director, is an Officer, Director and principal shareholder of Advanomics.


Note 12 – Subsequent Events
In April 2016, the Directors of the Company were issued an aggregate of 36,000,000 shares of the Company’s $0.001 par value Common Stock (12,000,000 shares per Director) in consideration for services rendered through December 31, 2015 valued at $36,000.
Our principal place of business is located at 469 Jean-Talon West, 3rd Floor, Montreal, Quebec, Canada H3N 1R4. Our phone number is (514) 764-9698 and our website address is www.sunshinebiopharma.com.


We have not been subject to any bankruptcy, receivership or similar proceeding.

Comparison of Results of Operations for the three months ended March 31, 2016 and 2015 (excerpt)
General and administrative expenses during the three month period ended March 31, 2016 were $69,682, compared to general and administrative expense of $124,825 incurred during the three month period ended March 31, 2015, a decrease of $55,143. This decrease is primarily attributable to the elimination of the $50,000 license fee we incurred during 2015 that we did not incur in the three months ended March 31, 2016 because we acquired the patent rights which were the subject of the license fee.

As a result, we incurred a net loss of $305,294 ($0.00 per share) for the three month period ended March 31, 2016, compared to a net loss of $294,367 ($0.00 per share) during the three month period ended March 31, 2015.

Acquisition of Patents (excerpt)

...we executed the aforesaid amendments to the original Patent Purchase Agreements which provided for (i) reduction of the purchase price of the Patents from $17,142,499 to $618,810, the Advanomics book value of the Patents, (ii) elimination of all cash payments obligations, and (iii) automatic convertibility of the new promissory notes for the new purchase price into an aggregate of 321,305,415 shares of Common Stock upon our increasing our authorized capital such that this number of Common Shares can be issued.

GMP Manufacturing (excerpt)
In June 2015 we received a sample of the scale-up manufacturing process for evaluation and confirmation of adherence to specifications. Based upon our laboratory analyses, the sample meets all of the required chemical, physical and biological specifications. The amount of material (the “Yield”) generated by this pilot run was found to be significantly lower than anticipated and we are currently working towards finding possible solutions to increase the Yield. If the timetable for generating the 2-kilogram quantity is met, of which there can be no assurance, and subject to receipt of the necessary financing, also for which no assurances can be provided, we expect to move into Phase I of our clinical trials in mid to late 2017.

Pursuant to the terms of the Lonza Agreement, Lonza will manufacture our drug in accordance with current Good Manufacturing Practices (“cGMP”) in compliance with the regulations applicable in the U.S., Canada, Europe and other countries around the world relating to the manufacturing of medicinal products for human use. Lonza will build a master drug file for our Adva-27a drug and will have it ready for filing with regulatory authorities as may be required to secure ultimate drug approval. The Lonza Agreement provides for us to maintain one representative of our Company at their facility during the manufacturing process. Quality assurance and control is the responsibility of both Lonza and us during the process.
http://www.sec.gov/Archives/edgar/data/1402328/000135448816007274/sbfm_10q.htm

http://www.sec.gov/Archives/edgar/data/1402328/000135448816006700/sbfm_10k.htm


=================================
http://www.antifraudcentre-centreantifraude.ca/reportincident-signalerincident/index-eng.htm

SEC Complaint process
https://denebleo.sec.gov/TCRExternal/index.xhtml
================================================================== 



 



http://sunshinebiopharma.com/investor/press-releases/
 
 
 
Sunshine Biopharma Media Contacts:
Renmark Financial Communications Inc.
Robert Thaemlitz: rthaemlitz@renmarkfinancial.com
Joshua Ciarrocca: jciarrocca@renmarkfinancial.com
Tel.: (416) 644-2020 or (514) 939-3989
www.renmarkfinacial.com
 
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
 
Lonza Media Contacts:
Colleen Floreck, +1 201 316 9290, colleen.floreck@lonza.com
Constance Ward, +41 61 316 8840, constance.ward@lonza.com
 
Manufacturing will begin at Lonza’s Nansha, China facility with the remaining key steps to be conducted in Lonza’s high containment cytotoxic facility in Visp, Switzerland.

Nansha China
http://www.lonza.com/about-lonza/company-profile/locations-worldwide/nansha-china.aspx

Visp Switzerland
http://www.lonza.com/about-lonza/company-profile/locations-worldwide/visp-switzerland.aspx




SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals
 
 

 
We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.

 
Intellectual Property

 
We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
 
 
Advanomics

http://www.canada-companies-info.com/advanomics-corporationcorporation-advanomics-65q2
Advanomics Corporation, the Parent Company of Sunshine Biopharma
 

Head Office:

Advanomics Corporation

2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Canada

Tel: 514-764-9698
Fax: 514-764-9699
info@advanomics.com

Sunshine Biopharma Media Contacts:
Renmark Financial Communications Inc.
Robert Thaemlitz: rthaemlitz@renmarkfinancial.com
Joshua Ciarrocca: jciarrocca@renmarkfinancial.com
Tel.: (416) 644-2020 or (514) 939-3989
www.renmarkfinacial.com
 
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
 

Product Pipeline

Our product pipeline is comprised of the following anti-tumor compounds:

Adva-27a

Difluoro-Etoposide™
Entering Phase I later this year (Lead Compound)

 

Adva-R46

RNAi Anti-Cancer drug candidate
Soon to enter animal studies phase

 

Adva-33c

Difluoro-Carboplatin™
Currently in preclinical phase



 



SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

http://corporatestock.com




Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Canada
Tel: 514-764-9698
Fax: 514-764-9699

http://sunshinebiopharma.com
info@sunshinebiopharma.com


 

 



 


 

 












































































 
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SureTrader
SBFM News: Information Statement - All Other (definitive) (def 14c) 06/13/2016 04:36:29 PM
SBFM News: Proxy Statement - Other Information (preliminary) (pre 14c) 06/01/2016 06:07:43 AM
SBFM News: Quarterly Report (10-q) 05/09/2016 05:01:36 PM
SBFM News: Statement of Changes in Beneficial Ownership (4) 04/26/2016 08:50:59 AM
SBFM News: Statement of Changes in Beneficial Ownership (4) 04/25/2016 07:36:27 AM
PostSubject
#31571  Sticky Note They have been changing the timeline for years BooDog 05/10/16 07:16:53 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#32292   Both have tremendous potential; excessive pumping isn't me; griffygriff3 06/24/16 05:06:39 PM
#32289   Brexit hard to anticipate dranesthesia1 06/24/16 11:26:11 AM
#32288   Next batd to anticipate . Lol dranesthesia1 06/24/16 11:26:03 AM
#32287   Call him around lunch time. That's usually BooDog 06/24/16 10:30:36 AM
#32286   Shouldn't have cancelled my order in the .005's BooDog 06/24/16 10:25:40 AM
#32285   Time to go up ! mandrake1 06/24/16 07:10:31 AM
#32284   The crap slilaty will screw you all dry, Cash Monster 06/23/16 10:55:28 PM
#32283   Camille the craphead turd master is in jail Cash Monster 06/23/16 10:53:02 PM
#32282   ...it's only $2000..... Kalinn 06/23/16 10:42:20 PM
#32281   Why the volume at such a premium today? dranesthesia1 06/23/16 04:12:02 PM
#32279   G'day everyone, just wanted to post an email iluvcanada 06/23/16 08:52:42 AM
#32278   Time to move up !! mandrake1 06/22/16 09:39:12 PM
#32277   Turd Camiile the craphead screwed us all, lied Cash Monster 06/22/16 09:18:40 PM
#32276   I think it's more like wasting time running Duke2484 06/22/16 05:04:55 PM
#32275   Maybe they don't want waste time with you KrazyQuestors 06/22/16 04:02:35 PM
#32274   I have 3 emails into info@ and Camille spacebird30 06/22/16 01:28:12 PM
#32273   Bankruptcy? Bawawawa!!!!! With no costs??? bearspread 06/22/16 01:04:04 PM
#32272   20 times less fortunately or unfortunately dranesthesia1 06/21/16 09:08:46 PM
#32271   There is nothing day to day in OTC. dranesthesia1 06/21/16 06:16:37 PM
#32270   Sounds good. I own 100,000 shares, I'm so Learjetter 06/21/16 05:44:34 PM
#32269   I don't think you own one share here And dranesthesia1 06/21/16 05:33:40 PM
#32268   Hey, if you want to go public, and Learjetter 06/21/16 05:31:29 PM
#32267   Would you answer if you called you in dranesthesia1 06/21/16 05:13:23 PM
#32266   Camille won't answer his phone or emails. Maybe Learjetter 06/21/16 02:49:16 PM
#32265   One thing for sure is we don't need bearspread 06/21/16 12:22:10 PM
#32264   Thanks boo. And agreed dranesthesia1 06/21/16 08:59:02 AM
#32263   Considering the SEC will neither confirm nor deny BooDog 06/21/16 07:37:55 AM
#32262   Biei was down 60% and I bought a dranesthesia1 06/21/16 07:10:42 AM
#32261   Have fun with it, down 60% this year!!! What's Learjetter 06/21/16 06:58:20 AM
#32260   Bankruptcy? Bawawawa!!!!! With no costs, dranesthesia1 06/21/16 05:41:07 AM
#32259   Just your opinions right wrong opinions, post & DD KrazyQuestors 06/20/16 11:06:31 PM
#32258   this company will flatline for 10 years and Kalinn 06/20/16 12:58:29 PM
#32257   My point is there are no pending or dranesthesia1 06/19/16 03:47:40 PM
#32256   Based on all of my DD and research, iluvcanada 06/19/16 03:45:24 PM
#32255   There are no pending or confirmed investigations dranesthesia1 06/19/16 10:58:54 AM
#32254   Read iluvcanada posts again, he references his efforts... Learjetter 06/19/16 10:42:42 AM
#32253   Links please??!! dranesthesia1 06/18/16 04:06:45 PM
#32252   ask him vip1999 06/18/16 04:06:01 PM
#32251   Links please!! dranesthesia1 06/18/16 02:53:08 PM
#32249   and various federal/state investigations open/pending. ... vip1999 06/18/16 01:01:33 AM
#32248   Hope not. I keep poking at it every vantillian 06/17/16 02:58:58 PM
#32247   Read iluvcanada posts and DD. This will continue Learjetter 06/17/16 02:34:24 PM
#32246   $SBFM needs to find a bottom. Keeps drifting vantillian 06/17/16 01:38:34 PM
#32245   Jaded bag holders should take a haircut. This Hoarder 06/16/16 08:43:49 PM
#32244   All the craphead camille the turd sebaaly wants Cash Monster 06/15/16 05:09:47 PM
#32243   The IND is in the toilet bowl with Cash Monster 06/15/16 04:34:22 PM
#32242   lesson in life, to keep me reminded =) Kalinn 06/15/16 03:01:19 PM
#32240   where is the IND? Kalinn 06/15/16 02:28:06 PM
#32239   Interesting action today on an otherwise anemic day dranesthesia1 06/15/16 01:00:36 PM
#32238   I am in too big to sell here dranesthesia1 06/15/16 11:50:42 AM
PostSubject