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Sunshine Biopharma Inc. (SBFM)

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Last Post: 7/31/2014 11:59:06 PM - Followers: 173 - Board type: Free - Posts Today: 0




"The Future Of Medicine"

Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options



Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.

Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug


OTCBB NEWS link http://www.otcbb.com/asp/Info_Center.asp
Dec 10, 2012 Sunshine Biopharma Completes Another IND-Enabling Study: Adva-27a Is Found to Be Effective Against Multidrug Resistant Uterine Cancer Cells
Dec 5, 2012 PennyTrackers.com Daily Watchlist: Sunshine Biopharma Inc. (OTCBB: SBFM), Biostar Pharmaceuticals, Inc. (NASDAQ: BSPM), Axia Group's (PINKSHEETS: AGIJ), Terralene Fuels Corporation (OTCQB: GSPT)
Dec 4, 2012 Sunshine Biopharma Completes Six IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Nov 27, 2012 Advanomics Corporation, the Parent Company of Sunshine Biopharma, Completes Acquisition of Adva-27a Patents
Nov 25, 2012 Insidebulls.com Volume Alerts: Medizone International (OTCQB: MZEI), SportsQuest, Inc. (PINKSHEETS: SPQS), Sunshine Biopharma Inc. (OTCBB: SBFM), Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH)
Nov 13, 2012 Sunshine Biopharma Initiates IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Oct 9, 2012 Sunshine Biopharma Receives Scale-Up Manufacturing Protocol for Its Lead Anti-Cancer Compound, Adva-27a
Sept 25, 2012 Les résultats des recherches précliniques sur l'Adva-27a de Sunshine Biopharma, seront publiés dans l'édition d'octobre d'ANTICANCER RESEARCH
Sept 25, 2012 Sunshine Biopharma's Adva-27a Preclinical Research Results to Be Published in October Issue of ANTICANCER RESEARCH
Sept 20, 2012 Breast Cancer News: Geron Drug Fails, Herceptin® May Increase Heart Problems, Sunshine Biopharma Heading for Clinical Trials

11/16/11 Sunshine Biopharma announces successful completion of preclinical studies for Adva-27a, the company's lead anti-cancer compound

10/5/11 Sunshine Biopharma's anti-cancer compound, Adva-27a, found to be a strong Topoisomerase II inhibitor

8/30/11 Clearance of Sunshine Biopharma's anti-cancer compound, Adva-27a, does not involve a toxic intermediate

8/10/11  Sunshine Biopharma Aims to Follow in Herceptin's Footsteps

8/2/11  Sunshine Biopharma Looking to Mimic Roche's Billion Dollar Cancer Drug Success

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals


SBFM Share Structure

From otcmarkets.com

Outstanding 51,391,092 a/o Nov 07, 2012
Float 13,916,529 a/o Mar 15, 2012
Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f


Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Tel: 514-764-9698
Fax: 514-764-9699





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SBFM News: Prospectus Filed Pursuant to Rule 424(b)(3) (424b3) 07/28/2014 04:05:06 PM
SBFM News: Notice of Effectiveness (effect) 07/24/2014 06:01:50 AM
SBFM News: Securities Registration Statement (s-1/a) 07/03/2014 06:02:21 AM
SBFM News: Sunshine Biopharma's Adva-27a Featured in 2014 Worldwide Uterine Cancer Report for Its Effectiveness Against Multidrug Resist... 06/09/2014 08:00:00 AM
SBFM News: Securities Registration Statement (s-1) 05/22/2014 04:48:18 PM
#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#10706  Sticky Note SUNSHINE BIOPHARMA INC (quick info) BooDog 09/12/13 07:25:24 AM
#16997   The month pigs fly to turdland$$ Cash Monster 07/31/14 11:59:06 PM
#16996   Slilaty the turd never has solid actions all Cash Monster 07/31/14 11:51:13 PM
#16995   Lol. In light of this positive news we reginaliberta 07/31/14 11:39:09 PM
#16994   No news, no ind, just all explosive hot Cash Monster 07/31/14 11:38:32 PM
#16993   The month of never. Never once Ceo materialized Cash Monster 07/31/14 11:31:21 PM
#16992   Expecting more news here..... reginaliberta 07/31/14 11:29:22 PM
#16991   Well then turdmaster should come out with some reginaliberta 07/31/14 11:28:20 PM
#16990   No dates, Ceo's is a turd. Cash Monster 07/31/14 11:26:31 PM
#16989   In looking for dates. reginaliberta 07/31/14 09:43:57 PM
#16988   Which month do u estimate they will file reginaliberta 07/31/14 09:42:24 PM
#16987   WE ARE ALL FED UP OF STEVE SLILATY'S Angel21stCentury 07/31/14 03:25:36 PM
#16986   WE WANT IND ON ADVA-27A TO THE FDA$$$$$$$ Angel21stCentury 07/31/14 03:20:50 PM
#16985   MAKE IT FAST AND GET TO WORK AND Angel21stCentury 07/31/14 03:02:04 PM
#16984   IMO the latest PR had been in the Doc_John 07/31/14 01:55:50 PM
#16983   WHERE ARE YOU DOCJOHN?? YOU BETTER ANSWER PEOPLES QUESTIONS. Angel21stCentury 07/31/14 12:41:31 PM
#16982   HOLD ON TO YOUR UNDERWEARS$$$$$$$$$ Angel21stCentury 07/30/14 09:25:05 PM
#16981   GET READY BRO,NEWS,NEWS,NEWS,AND MORE NEWS IS ON THE WAY$$$$$$$ Angel21stCentury 07/30/14 09:19:18 PM
#16980   SBFM is a monster turd with a bad Cash Monster 07/30/14 08:03:12 PM
#16979   Eating hot tacos so this turd could explode Cash Monster 07/30/14 07:56:36 PM
#16978   So ok docjohn.. Gimme an idea/speculation on a pijoe 07/30/14 07:50:40 PM
#16977   Ha I never had a whiz I didn't pijoe 07/30/14 07:46:05 PM
#16976   WHAT WILL YOU DO WHEN ADVA-27A RUNS WILD Angel21stCentury 07/30/14 07:35:24 PM
#16975   YOU MAKE SURE THEY STAY WITH THEIR MOUTH'S Angel21stCentury 07/30/14 07:32:46 PM
#16974   BRO,ALL ABOARD THE FUTURE OF MEDICINE http://m.youtube.com/watch?v=OnoNITE-CLc Angel21stCentury 07/30/14 07:28:05 PM
#16973   Hahaha - so true! Doc_John 07/30/14 02:54:31 PM
#16972   Don't worry bros. I get the feeling that reportmyabuse 07/30/14 02:33:40 PM
#16971   TAKE OUT THE BILLION$$$$$$$$ BOMB$$$$$$$$$$$$$ Angel21stCentury 07/30/14 12:13:44 PM
#16970   ADVA-27A:WE WILL NOT FAULTER, WE WILL NOT FAIL,WE Angel21stCentury 07/30/14 12:10:07 PM
#16969   ADVA-27A WILL WIN THE WAR AGAINST CANCER. TIME Angel21stCentury 07/30/14 12:07:02 PM
#16968   Now your last chance to catch these low Doc_John 07/30/14 11:07:01 AM
#16967   DR.STEVE SLILATY WILL SHOCK THE WORLD WITH THE Angel21stCentury 07/29/14 06:14:44 PM
#16966   Looks like Ceo will materialize an event for Cash Monster 07/29/14 05:56:55 PM
#16965   SBFM will explode with all the turd gas accumulation. Cash Monster 07/29/14 05:52:37 PM
#16964   This turd just turned to gold$ it's the Cash Monster 07/29/14 05:50:44 PM
#16963   I must missed that part I read in pijoe 07/29/14 05:41:10 PM
#16962   HAIL CANCERS HOLY GRAIL MIRACLE DRUG ADVA-27A Angel21stCentury 07/29/14 05:41:00 PM
#16961   BLOCKBUSTER ADVA-27A WILL REAP ASTRONOMICAL REWARDS FOR ALL$$$$$$$$$$ Angel21stCentury 07/29/14 05:25:51 PM
#16960   It's in the most recent prospectus. Doc_John 07/29/14 05:23:47 PM
#16959   NEWS,NEWS,NEWS,AND MORE NEWS IS ON THE WAY$$$$$$$$$$ Angel21stCentury 07/29/14 05:22:07 PM
#16958   Per the prospectus filed yesterday ~ "In particular, Chocotacos 07/29/14 05:17:23 PM
#16957   What idea and/or reasoning would make you think pijoe 07/29/14 05:02:20 PM
#16956   THE FAT LADY WILL SING OHHHHHH CANADA$$$$$$$$$$$$ Angel21stCentury 07/29/14 04:23:23 PM
#16955   AN INTERNATIONAL EARTHQUAKE WILL HIT FROM COAST TO Angel21stCentury 07/29/14 04:18:08 PM
#16954   ITS ATOMIC,Y'ALL HOLD ON TIGHT$$$$$$$$$$$ Angel21stCentury 07/29/14 04:11:03 PM
#16953   encouraging Kalinn 07/29/14 04:03:31 PM
#16952   TAKE OUT THE BILLION DOLLAR ANTI-CANCER DRUG ADVA-27A Angel21stCentury 07/29/14 03:26:52 PM
#16951   TAKE OUT THE BEAST$$$$$$$$$$$$$ Angel21stCentury 07/29/14 02:52:09 PM
#16950   I like the idea that they are starting vip1999 07/29/14 01:47:24 PM
#16949   News is out folks.. The wheels are in motion. http://finance.yahoo.com/news/sun Doc_John 07/29/14 12:00:46 PM
#16948   Profits are going to be rolling in very Doc_John 07/29/14 11:58:40 AM