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Sunshine Biopharma Inc. (SBFM)

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Last Post: 4/16/2014 5:23:46 PM - Followers: 187 - Board type: Free - Posts Today: 26




"The Future Of Medicine"

Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options



Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

The U.S. Food and Drug Administration's (FDA) approval process is likely to be granted fast-track designation since Adva-27a has the potential to help terminally ill patients with no other therapy options and can be used to treat multiple cancer types. As a result of its unique capabilities, versatility and lack of competition, Sunshine Biopharma's Lead Compound could significantly exceed the typical Revenues generated from anti-cancer drugs, which in general reach $1 Billion in annual sales within two or three years of FDA Approval.

Sunshine Biopharma Drug Pipeline

Adva-27a - Completed Preclinicals
Compound for Small-Cell Lung Cancer - In Preclinical Studies
A Third RNAi-Based Drug


Dec 10, 2012 Sunshine Biopharma Completes Another IND-Enabling Study: Adva-27a Is Found to Be Effective Against Multidrug Resistant Uterine Cancer Cells
Dec 5, 2012 Daily Watchlist: Sunshine Biopharma Inc. (OTCBB: SBFM), Biostar Pharmaceuticals, Inc. (NASDAQ: BSPM), Axia Group's (PINKSHEETS: AGIJ), Terralene Fuels Corporation (OTCQB: GSPT)
Dec 4, 2012 Sunshine Biopharma Completes Six IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Nov 27, 2012 Advanomics Corporation, the Parent Company of Sunshine Biopharma, Completes Acquisition of Adva-27a Patents
Nov 25, 2012 Volume Alerts: Medizone International (OTCQB: MZEI), SportsQuest, Inc. (PINKSHEETS: SPQS), Sunshine Biopharma Inc. (OTCBB: SBFM), Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH)
Nov 13, 2012 Sunshine Biopharma Initiates IND-Enabling Studies for Its Anticancer Compound, Adva-27a
Oct 9, 2012 Sunshine Biopharma Receives Scale-Up Manufacturing Protocol for Its Lead Anti-Cancer Compound, Adva-27a
Sept 25, 2012 Les résultats des recherches précliniques sur l'Adva-27a de Sunshine Biopharma, seront publiés dans l'édition d'octobre d'ANTICANCER RESEARCH
Sept 25, 2012 Sunshine Biopharma's Adva-27a Preclinical Research Results to Be Published in October Issue of ANTICANCER RESEARCH
Sept 20, 2012 Breast Cancer News: Geron Drug Fails, Herceptin® May Increase Heart Problems, Sunshine Biopharma Heading for Clinical Trials

11/16/11 Sunshine Biopharma announces successful completion of preclinical studies for Adva-27a, the company's lead anti-cancer compound

10/5/11 Sunshine Biopharma's anti-cancer compound, Adva-27a, found to be a strong Topoisomerase II inhibitor

8/30/11 Clearance of Sunshine Biopharma's anti-cancer compound, Adva-27a, does not involve a toxic intermediate

8/10/11  Sunshine Biopharma Aims to Follow in Herceptin's Footsteps

8/2/11  Sunshine Biopharma Looking to Mimic Roche's Billion Dollar Cancer Drug Success

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals


SBFM Share Structure


Outstanding 51,391,092 a/o Nov 07, 2012
Float 13,916,529 a/o Mar 15, 2012
Authorized Shares 200,000,000 a/o Dec 31, 2011

31.5 million held by Steve Slilaty, CEO

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

Sunshine Biopharma Inc.
2015 Peel Street
5th Floor
Montreal, Quebec H3A 1T8
Tel: 514-764-9698
Fax: 514-764-9699




#11692  Sticky Note Please stay on topic. The only topic to IH Admin [Dan] 10/09/13 10:52:01 AM
#10706  Sticky Note SUNSHINE BIOPHARMA INC (quick info) BooDog 09/12/13 07:25:24 AM
#15743   Amen to that my brother! Doc_John 04/16/14 05:23:46 PM
#15742   breast cancer cure and SBFM blows up to Penny Planet 04/16/14 05:21:12 PM
#15741   Yea buddy. This can be our new board. taubytaub 04/16/14 05:18:02 PM
#15740   the MYE(C) board has autism now, I cant Penny Planet 04/16/14 05:15:33 PM
#15739   Looking forward to news taubytaub 04/16/14 05:12:54 PM
#15738   ppl are going to wonder where all the Penny Planet 04/16/14 05:11:41 PM
#15737   Uh oh! Whale alert! taubytaub 04/16/14 05:09:33 PM
#15736   final stages of drug synthesis stages of Doc_John 04/16/14 04:44:46 PM
#15735   almost done loading ;-) Penny Planet 04/16/14 04:40:18 PM
#15734   Come slap da ask! taubytaub 04/16/14 02:20:00 PM
#15733   She's about to blow! Hit it hard my friend. Doc_John 04/16/14 01:57:28 PM
#15732   Fire away! Doc_John 04/16/14 01:50:17 PM
#15731   seems like a share are tight >>>>>>>o/s Tonyeight 04/16/14 12:25:20 PM
#15730   Yeah, I've never had any luck getting shares G Bert 04/16/14 12:03:11 PM
#15729   SBFM last pr nice..better to follow Abondanceinvest 04/16/14 11:30:28 AM
#15728   sbfm sunshine$ radar!!!!!!!!!!!! Abondanceinvest 04/16/14 11:29:13 AM
#15727   Welcome! Doc_John 04/16/14 11:24:17 AM
#15726   I love it when we get first time Doc_John 04/16/14 10:42:39 AM
#15725   I believe some have gotten a few shares pijoe 04/16/14 10:35:42 AM
#15724   gm to all ==HANGGING THERE ==FOLKS>>>>>>>> TIME WILL Tonyeight 04/16/14 09:59:26 AM
#15723   Makes sense, looking like a bankrupt biopharma Cash Monster 04/16/14 09:10:12 AM
#15722   This turd does act strange, let's see if Cash Monster 04/16/14 09:01:20 AM
#15721   Negative......seems like your wrong on that one. Cash Monster 04/16/14 08:46:05 AM
#15720   Im still here sent by the heavens above. Angel21stCentury 04/16/14 06:02:38 AM
#15719   This company is moving very slowly, if you vip1999 04/16/14 01:55:43 AM
#15718   It will be back! vip1999 04/16/14 01:54:30 AM
#15717   I disnt even notice him unless someone responded pijoe 04/15/14 08:44:25 PM
#15716   Im just happy angel is gone taubytaub 04/15/14 08:32:00 PM
#15715   I didnt say big like i made $20000 pijoe 04/15/14 07:54:49 PM
#15714   I don't think Volume has been there to Doc_John 04/15/14 07:53:09 PM
#15713   an infant of 5 years old can at sin vester 04/15/14 07:51:17 PM
#15712   Since it last hit .15 this past year pijoe 04/15/14 07:46:11 PM
#15711   That can't be recently Doc_John 04/15/14 07:43:18 PM
#15710   What for this is still in infancy Doc_John 04/15/14 07:42:52 PM
#15709   How long will the CEO lie? oh sin vester 04/15/14 07:41:28 PM
#15708   Ive done it over 3 times thx pijoe 04/15/14 06:07:12 PM
#15707   Something seems fishy with ceo always hiding from sin vester 04/15/14 05:06:23 PM
#15706   Thank you! After all of this time, I reportmyabuse 04/15/14 04:48:11 PM
#15705   Highly likely we get news on IND progress tomorrow. Doc_John 04/15/14 04:28:14 PM
#15704   Roaches check in, but they don't check out. G Bert 04/15/14 04:20:28 PM
#15703   Highly unlikely.. Doc_John 04/15/14 04:05:38 PM
#15702   You will get em at .16 if you pijoe 04/15/14 03:19:03 PM
#15701   How many shares u bidding. Im only looking taubytaub 04/15/14 03:11:23 PM
#15700   Dump them all to me..... Waiting........ Cash Monster 04/15/14 03:10:24 PM
#15699   Lets hope. taubytaub 04/15/14 03:09:18 PM
#15698   Things are about to change around here. Cash Monster 04/15/14 03:06:53 PM
#15697   Fill me I'm there waiting for your shares Cash Monster 04/15/14 03:03:58 PM
#15696   How come we never heard of this effective sin vester 04/15/14 02:46:05 PM
#15695   I want out. Nobody will buy though. taubytaub 04/15/14 02:45:12 PM
#15694   What do you hate it for? All pijoe 04/15/14 02:39:13 PM